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PtlB PtlB IdsB IdsB Cyp14 Cyp14 cyc1 cyc1 ispH ispH uppS uppS ispE ispE KUN57042.1 KUN57042.1 idi idi dxs1 dxs1 LitS LitS LitR LitR KUN55458.1 KUN55458.1 CrtV CrtV crtI-2 crtI-2 CrtI CrtI CrtE CrtE CrtY CrtY crtT crtT CrtU CrtU GrcC GrcC dxs2 dxs2 cyc2 cyc2 UppS2 UppS2 ispD ispD ispF ispF Dxr Dxr Ams Ams
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PtlBDimethylallyltranstransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (337 aa)
IdsBPolyprenyl synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (394 aa)
Cyp14Cytochrome P450; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
cyc1Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
uppSUDP pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (257 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (297 aa)
KUN57042.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
idiIsopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (197 aa)
dxs11-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
LitSRNA polymerase subunit sigma-24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (204 aa)
LitRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
KUN55458.1Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
CrtV2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
crtI-2Phytoene synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
CrtIPhytoene dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
CrtEGeranylgeranyl pyrophosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (413 aa)
CrtYLycopene cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
crtTUbiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
CrtUIsorenieratene synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
GrcCGeranylgeranyl pyrophosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (336 aa)
dxs21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
cyc2Geosmin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (725 aa)
UppS2UDP pyrophosphate synthase; Catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (250 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (174 aa)
Dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AmsTerpene cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
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