STRINGSTRING
IcmA IcmA LysA3 LysA3 IcmB IcmB rocD rocD glyA_1 glyA_1 McmA2 McmA2 MetB MetB IlvA IlvA AspB3 AspB3 Nrps1-1 Nrps1-1 thrC thrC KUN56372.1 KUN56372.1 Nrps3-3 Nrps3-3 Nrps3-2 Nrps3-2 AspB2 AspB2 kgd kgd DndA DndA lysA_1 lysA_1 ThrC1 ThrC1 glyA_2 glyA_2 mcmA mcmA OlmA1 OlmA1 KUN57231.1 KUN57231.1 OlmA2 OlmA2 olmA3 olmA3 OlmA5 OlmA5 BioF BioF rocD-2 rocD-2 IolD2 IolD2 KUN53237.1 KUN53237.1 Nrps4 Nrps4 Pks4 Pks4 AvsD AvsD Pks1-2 Pks1-2 Pks1-3 Pks1-3 Nrps5 Nrps5 MetH MetH argD argD KUN53538.1 KUN53538.1 KUN54655.1 KUN54655.1 KUN54397.1 KUN54397.1 KUN54324.1 KUN54324.1 hisC hisC KUN54251.1 KUN54251.1 csd csd ectB ectB CobC CobC KUN54886.1 KUN54886.1 KUN54816.1 KUN54816.1 KUN55311.1 KUN55311.1 IlvB2 IlvB2 KUN55147.1 KUN55147.1 Pks2-2 Pks2-2 kbl kbl KUN54951.1 KUN54951.1 dxs1 dxs1 KUN55508.1 KUN55508.1 KUN55932.1 KUN55932.1 IlvB3 IlvB3 KUN55850.1 KUN55850.1 KUN55775.1 KUN55775.1 AspB1 AspB1 Gcl Gcl McmB McmB MeaA2 MeaA2 BioA BioA PoxB2 PoxB2 ThrC3 ThrC3 serC serC KUN56991.1 KUN56991.1 KUN56797.1 KUN56797.1 Nrps2-2 Nrps2-2 Nrps2-1 Nrps2-1 GadB1 GadB1 Mgl Mgl gcvP gcvP KUN52915.1 KUN52915.1 cysA cysA pat pat hemL hemL KUN52501.1 KUN52501.1 KorB KorB AspC1 AspC1 alr alr KUN52360.1 KUN52360.1 IolD1 IolD1 SidD SidD IlvB4 IlvB4 DapC DapC kynU kynU EutC EutC KUN51570.1 KUN51570.1 GadB2 GadB2 GlgP GlgP KUN51327.1 KUN51327.1 glyA_1-2 glyA_1-2 KUN51349.1 KUN51349.1 IlvB1 IlvB1 TbpA TbpA KUN51485.1 KUN51485.1 KUN51260.1 KUN51260.1 Nrps7-4 Nrps7-4 Nrps7-11 Nrps7-11 lysA_2 lysA_2 PteA1 PteA1 KUN51001.1 KUN51001.1 RocD3 RocD3 Pks3-3 Pks3-3 Pks3-2 Pks3-2 dxs2 dxs2 KUN50515.1 KUN50515.1 nrdJ nrdJ KUN50447.1 KUN50447.1 GabT GabT KUN49806.1 KUN49806.1 PoxB1 PoxB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IcmAmethylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
LysA3Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
IcmBmethylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
rocDOrnithine--oxo-acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
glyA_1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa)
McmA2methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
MetBCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
IlvAThreonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
AspB3Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
Nrps1-1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1768 aa)
thrCThreonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
KUN56372.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
Nrps3-3Non-ribosomal peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1061 aa)
Nrps3-2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AspB2Succinyldiaminopimelate transaminase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1276 aa)
DndACysteine desulfurase DndA; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
lysA_1Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
ThrC1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
glyA_2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
mcmAMcmA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
OlmA1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (4236 aa)
KUN57231.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1758 aa)
OlmA2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (4843 aa)
olmA3Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3939 aa)
OlmA5Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1907 aa)
BioF8-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
rocD-2Ornithine--oxo-acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa)
IolD23D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (624 aa)
KUN53237.14-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa)
Nrps4Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (905 aa)
Pks4Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1517 aa)
AvsDDiaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
Pks1-2Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1509 aa)
Pks1-3Erythronolide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2355 aa)
Nrps5Amino acid adenylation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1291 aa)
MetHMethionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
argDAcetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa)
KUN53538.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
KUN54655.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
KUN54397.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sulfur carrier protein TusA family. (460 aa)
KUN54324.1Alanine racemase; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (239 aa)
hisCAspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa)
KUN54251.1Amino acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
csdCysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
ectBDiaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
CobCAminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
KUN54886.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
KUN54816.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
KUN55311.1Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (647 aa)
IlvB2Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (598 aa)
KUN55147.1Molybdenum cofactor biosysynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
Pks2-2Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (4809 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
KUN54951.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa)
dxs11-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
KUN55508.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
KUN55932.1Pyridoxine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
IlvB3Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (564 aa)
KUN55850.1Aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
KUN55775.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
AspB1Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
GclGlyoxylate carboligase; Catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (591 aa)
McmBmethylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
MeaA2methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
BioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
PoxB2Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
ThrC3Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
KUN56991.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron/ascorbate-dependent oxidoreductase family. (345 aa)
KUN56797.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
Nrps2-2Non-ribosomal peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1709 aa)
Nrps2-1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (3691 aa)
GadB1Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (454 aa)
MglCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
KUN52915.1Alanine racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
cysACystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
KUN52501.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron/ascorbate-dependent oxidoreductase family. (324 aa)
KorB2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AspC1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (391 aa)
KUN52360.1Sulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
IolD13D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (627 aa)
SidDPyridoxal-dependent decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
IlvB4Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (561 aa)
DapCAminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (394 aa)
EutCEthanolamine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the EutC family. (262 aa)
KUN51570.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
GadB2Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (470 aa)
GlgPGlycogen phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (878 aa)
KUN51327.1Molybdenum cofactor biosysynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
glyA_1-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
KUN51349.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
IlvB1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
TbpAABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
KUN51485.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
KUN51260.1Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1052 aa)
Nrps7-4Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1143 aa)
Nrps7-11Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
lysA_2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (447 aa)
PteA1Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (5479 aa)
KUN51001.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
RocD3Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
Pks3-3Acyl carrier protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
Pks3-2Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1875 aa)
dxs21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
KUN50515.12,4-diaminobutyrate 4-aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
nrdJVitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (964 aa)
KUN50447.1Amino acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
GabT4-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
KUN49806.1Oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
PoxB1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.