STRINGSTRING
glpQ glpQ PrpM4 PrpM4 glnE glnE PhoC PhoC KUN54468.1 KUN54468.1 KUN53032.1 KUN53032.1 PhoA PhoA KUN54598.1 KUN54598.1 KUN54725.1 KUN54725.1 GlpQ4 GlpQ4 GlpQ3 GlpQ3 PrpB12 PrpB12 mtnC mtnC KUN53941.1 KUN53941.1 AQJ43_17775 AQJ43_17775 PrpL3 PrpL3 KUN53367.1 KUN53367.1 PtpA1 PtpA1 MprB MprB KUN50198.1 KUN50198.1 KUN50449.1 KUN50449.1 Dgt Dgt suhB_1 suhB_1 PrpC7 PrpC7 PrpL4 PrpL4 KUN50171.1 KUN50171.1 GlpQ1 GlpQ1 PrpG1 PrpG1 KUN55789.1 KUN55789.1 PrpB9 PrpB9 PhoD2 PhoD2 PrpJ7 PrpJ7 PtpB3 PtpB3 PtpA3 PtpA3 KUN56193.1 KUN56193.1 hisN hisN KUN56353.1 KUN56353.1 KUN56393.1 KUN56393.1 PrpM3 PrpM3 KUN56395.1 KUN56395.1 GlpX GlpX PrpE2 PrpE2 KUN56560.1 KUN56560.1 KUN56606.1 KUN56606.1 KUN57167.1 KUN57167.1 KUN57017.1 KUN57017.1 PrpJ6 PrpJ6 OtsB OtsB KUN55977.1 KUN55977.1 KUN55978.1 KUN55978.1 KUN55987.1 KUN55987.1 GlpQ6 GlpQ6 KUN54231.1 KUN54231.1 PhoD1 PhoD1 PrpJ4 PrpJ4 PrpF PrpF PrpB3 PrpB3 PrpI2 PrpI2 PrpB4 PrpB4 KUN54780.1 KUN54780.1 PrpB5 PrpB5 PrpC5 PrpC5 cpdA cpdA PrpB6 PrpB6 PrpJ5 PrpJ5 GlpQ5 GlpQ5 PrpB2 PrpB2 KUN49105.1 KUN49105.1 PrpE1 PrpE1 KUN54960.1 KUN54960.1 PtpA2 PtpA2 plcC plcC KUN55951.1 KUN55951.1 KUN55940.1 KUN55940.1 KUN55855.1 KUN55855.1 KUN55851.1 KUN55851.1 KUN55820.1 KUN55820.1 SerB2 SerB2 PhoB PhoB KUN54144.1 KUN54144.1 nfo nfo KUN50562.1 KUN50562.1 KUN50504.1 KUN50504.1 OsaB OsaB OsaC OsaC PrpC1 PrpC1 KUN50768.1 KUN50768.1 PrpJ1 PrpJ1 PrpL1 PrpL1 KUN50850.1 KUN50850.1 PrpM1 PrpM1 suhB_2 suhB_2 PrpB1 PrpB1 PrpC4 PrpC4 PrpC3 PrpC3 ntdB ntdB PrpC2 PrpC2 PrpJ3 PrpJ3 PrpJ2 PrpJ2 glnD glnD KUN51496.1 KUN51496.1 KUN51321.1 KUN51321.1 KUN51758.1 KUN51758.1 KUN51853.1 KUN51853.1 KUN51822.1 KUN51822.1 KUN51816.1 KUN51816.1 KUN51893.1 KUN51893.1 KUN52007.1 KUN52007.1 KUN51987.1 KUN51987.1 PrpB10 PrpB10 KUN52087.1 KUN52087.1 PrpB11 PrpB11 KUN52195.1 KUN52195.1 PrpK PrpK KUN52647.1 KUN52647.1 KUN52481.1 KUN52481.1 mprB_1-2 mprB_1-2 PrpI3 PrpI3 PrpC6 PrpC6 mprB_1 mprB_1 GlpQ2 GlpQ2 KUN52956.1 KUN52956.1 KUN52947.1 KUN52947.1 ptpA ptpA PrpB8 PrpB8 PrpE3 PrpE3 KUN52817.1 KUN52817.1 PrpG2 PrpG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glpQGlycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
PrpM4Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (690 aa)
glnEBifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] (1000 aa)
PhoCAcid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
KUN54468.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
KUN53032.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
PhoAAlkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
KUN54598.1Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
KUN54725.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
GlpQ4Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
GlpQ3Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
PrpB12Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
mtnCEnolase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (239 aa)
KUN53941.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AQJ43_17775Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
PrpL3PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (785 aa)
KUN53367.1Diguanylate phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (717 aa)
PtpA1Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
MprBHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
KUN50198.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
KUN50449.1Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
DgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
suhB_1Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (272 aa)
PrpC7PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (847 aa)
PrpL4PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (797 aa)
KUN50171.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
GlpQ1Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
PrpG1Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
KUN55789.1Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
PrpB9Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
PhoD2Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
PrpJ7Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (794 aa)
PtpB3Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (221 aa)
PtpA3Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
KUN56193.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
hisNHistidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
KUN56353.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
KUN56393.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
PrpM3PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (933 aa)
KUN56395.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
GlpXFructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
PrpE2Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
KUN56560.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
KUN56606.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
KUN57167.1Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
KUN57017.12'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (190 aa)
PrpJ6Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
OtsBTrehalose phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (287 aa)
KUN55977.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
KUN55978.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
KUN55987.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
GlpQ6Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
KUN54231.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
PhoD1Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
PrpJ4PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
PrpFAntitermination regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (787 aa)
PrpB3Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
PrpI2Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
PrpB4Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
KUN54780.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
PrpB5Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
PrpC5Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
cpdA3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (261 aa)
PrpB6Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
PrpJ5Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (804 aa)
GlpQ5Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
PrpB2Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
KUN49105.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
PrpE1Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
KUN54960.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
PtpA2Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
plcCPhospholipase C, phosphocholine-specific; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
KUN55951.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
KUN55940.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
KUN55855.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (691 aa)
KUN55851.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
KUN55820.1PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (820 aa)
SerB2Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
PhoBSecreted acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
KUN54144.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (310 aa)
KUN50562.1Phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
KUN50504.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
OsaBHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
OsaCPAS domain S-box protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (873 aa)
PrpC1Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
KUN50768.12'-5' RNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
PrpJ1Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (770 aa)
PrpL1Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (820 aa)
KUN50850.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
PrpM1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (808 aa)
suhB_23'(2'),5'-bisphosphate nucleotidase CysQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
PrpB1Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
PrpC4Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (785 aa)
PrpC3Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
ntdBHydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
PrpC2Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
PrpJ3Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (909 aa)
PrpJ2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (675 aa)
glnDprotein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (818 aa)
KUN51496.1Phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (988 aa)
KUN51321.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
KUN51758.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
KUN51853.1Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
KUN51822.1Histidine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
KUN51816.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (620 aa)
KUN51893.1Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
KUN52007.1Ribosylglycohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
KUN51987.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
PrpB10Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
KUN52087.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
PrpB11Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
KUN52195.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
PrpKProtein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (750 aa)
KUN52647.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
KUN52481.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
mprB_1-2Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
PrpI3PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
PrpC6Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (922 aa)
mprB_1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
GlpQ2Glycerophosphodiester phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
KUN52956.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
KUN52947.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
ptpAProtein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (163 aa)
PrpB8Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
PrpE3Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
KUN52817.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
PrpG2Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
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