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KUN51952.1 KUN51952.1 pta pta ackA ackA ThrA ThrA DndC DndC KUN56301.1 KUN56301.1 mshB mshB MetB MetB FolD1 FolD1 CysM1 CysM1 CysK2 CysK2 MtaP MtaP KUN56858.1 KUN56858.1 mqnB mqnB KUN57055.1 KUN57055.1 cysC_1 cysC_1 mmuM mmuM KUN55660.1 KUN55660.1 metE metE AcsA4 AcsA4 Ggt2 Ggt2 Ggt1 Ggt1 KUN56010.1 KUN56010.1 dxs1 dxs1 kbl kbl KUN54975.1 KUN54975.1 CysK1 CysK1 SsuA1 SsuA1 KUN55232.1 KUN55232.1 KUN55372.1 KUN55372.1 AQJ43_11925 AQJ43_11925 trpA trpA MetF MetF ThiE ThiE GoxB GoxB ThiS ThiS thiG thiG lipA lipA KUN54641.1 KUN54641.1 AcsA2 AcsA2 MetK MetK MetH MetH mtnK mtnK mtnD mtnD mtnC mtnC mtnA_2 mtnA_2 mshC mshC KUN53900.1 KUN53900.1 egtA egtA egtB egtB EgtC EgtC egtD egtD AvsA AvsA GlgA GlgA thiD thiD cysK_2 cysK_2 BioF BioF bioB bioB BioA BioA bioD bioD Mgl Mgl pdhA pdhA BkdA BkdA cysA cysA thiC thiC KUN52464.1 KUN52464.1 KUN52610.1 KUN52610.1 asd_2 asd_2 KUN52133.1 KUN52133.1 Eif1 Eif1 KUN51953.1 KUN51953.1 cysM cysM KUN51570.1 KUN51570.1 Asd1 Asd1 AcsA1 AcsA1 KUN51356.1 KUN51356.1 thiL thiL KUN51485.1 KUN51485.1 KUN51182.1 KUN51182.1 KUN51257.1 KUN51257.1 KUN51282.1 KUN51282.1 CysC2 CysC2 TagE TagE dxs2 dxs2 KUN50819.1 KUN50819.1 AcsA3 AcsA3 AccD3 AccD3 KUN50448.1 KUN50448.1 mshD mshD MshA MshA folD_2 folD_2 KUN47763.1 KUN47763.1 KUN47764.1 KUN47764.1 KUN47772.1 KUN47772.1 KUN46589.1 KUN46589.1 cysD cysD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KUN51952.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
ThrAHomoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
DndCSulfurtransferase DndC; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
KUN56301.1Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] (392 aa)
mshBN-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (294 aa)
MetBCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
FolD1THF_DHG_CYH domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
CysM1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
CysK22,3-diaminopropionate biosynthesis protein SbnA; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
MtaPPurine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (277 aa)
KUN56858.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
mqnBFutalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (223 aa)
KUN57055.1Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
cysC_1Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (178 aa)
mmuMHomocysteine S-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
KUN55660.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
AcsA4AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
Ggt2Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (599 aa)
Ggt1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (610 aa)
KUN56010.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
dxs11-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
KUN54975.1GlcNAc-PI de-N-acetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
CysK1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
SsuA1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
KUN55232.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
KUN55372.1acyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
AQJ43_11925VOC domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (277 aa)
MetF5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (307 aa)
ThiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (215 aa)
GoxBGlycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ThiSThiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (328 aa)
KUN54641.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AcsA2acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
MetKCatalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
MetHMethionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (372 aa)
mtnDCupin; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (197 aa)
mtnCEnolase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (239 aa)
mtnA_2Initiation factor 2B subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (343 aa)
mshCcysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (409 aa)
KUN53900.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
egtAErgothioneine biosynthesis glutamate--cysteine ligase EgtA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (424 aa)
egtBSulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (440 aa)
EgtCClass II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
egtDDimethylhistidine N-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (333 aa)
AvsASiderophore biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
GlgAGlycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
thiDHydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
cysK_22,3-diaminopropionate biosynthesis protein SbnA; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
BioF8-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (388 aa)
BioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa)
MglCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
BkdAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
cysACystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (601 aa)
KUN52464.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
KUN52610.1LmbE family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (704 aa)
asd_2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
KUN52133.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
Eif1Initiation factor 2B subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eIF-2B alpha/beta/delta subunits family. (382 aa)
KUN51953.1Molybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
cysMCysteine synthase; Catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
KUN51570.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
Asd1Aspartate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
AcsA1Acetyl-coenzyme A synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (652 aa)
KUN51356.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (320 aa)
KUN51485.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
KUN51182.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
KUN51257.1Hypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (245 aa)
KUN51282.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
CysC2Adenylyl-sulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
TagEUDP-glucose--polyglycerol phosphate glucosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
dxs21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
KUN50819.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
AcsA3acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
AccD3acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
KUN50448.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
mshDMycothiol synthase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (308 aa)
MshAD-inositol-3-phosphate glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
folD_2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
KUN47763.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
KUN47764.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
KUN47772.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
KUN46589.1GlcNAc-PI de-N-acetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
cysDSulfate adenylyltransferase subunit 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
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