STRINGSTRING
purU purU KUN57164.1 KUN57164.1 MoaA1 MoaA1 moaC moaC MoaB MoaB ispE ispE prs prs glmU glmU guaA guaA purN purN purH purH FolD1 FolD1 KUN56596.1 KUN56596.1 Add3 Add3 KUN56539.1 KUN56539.1 CyaA CyaA ispH ispH MoaE MoaE nrdB nrdB KUN56238.1 KUN56238.1 IdsB IdsB PtlB PtlB atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC ackA ackA pta pta thiC thiC upp upp purD purD purC purC purS purS purQ purQ purL purL purF purF PurM PurM KUN52435.1 KUN52435.1 Add4 Add4 Adk Adk Ino1 Ino1 coaA coaA guaB guaB GuaB2 GuaB2 KUN52379.1 KUN52379.1 purK purK purE purE KUN52322.1 KUN52322.1 nadD nadD KUN52282.1 KUN52282.1 ndk ndk KUN51923.1 KUN51923.1 PncA PncA PncB PncB KUN51817.1 KUN51817.1 dcd dcd GptA GptA KUN51695.1 KUN51695.1 pyrE pyrE kynU kynU KUN51565.1 KUN51565.1 purA purA KUN51593.1 KUN51593.1 AcsA1 AcsA1 HprT HprT folE folE NadB NadB NadC NadC coaX coaX PlsC2 PlsC2 gpsA gpsA thiL thiL coaD coaD pyrH pyrH CdsA CdsA KUN51182.1 KUN51182.1 KUN51257.1 KUN51257.1 KUN51282.1 KUN51282.1 KUN50946.1 KUN50946.1 KUN50958.1 KUN50958.1 dxs2 dxs2 KUN50820.1 KUN50820.1 PgsA4 PgsA4 AcsA3 AcsA3 KUN50759.1 KUN50759.1 KUN50680.1 KUN50680.1 PgsA1 PgsA1 CinA CinA tdk tdk dut dut AccD3 AccD3 MoaD MoaD ispD ispD ispF ispF KUN50077.1 KUN50077.1 KUN50092.1 KUN50092.1 PrsA2 PrsA2 Dxr Dxr RibF RibF thyX thyX folD_2 folD_2 Cdh Cdh KUN49110.1 KUN49110.1 KUN47763.1 KUN47763.1 KUN47764.1 KUN47764.1 KUN47772.1 KUN47772.1 KUN47262.1 KUN47262.1 BkdA BkdA MobA MobA MoaA2 MoaA2 pdhA pdhA PgsA3 PgsA3 PurB PurB PlsC6 PlsC6 KUN53095.1 KUN53095.1 thiD thiD PlsC7-2 PlsC7-2 AvsA AvsA ppnK ppnK pyrG pyrG cmk cmk PlsC7 PlsC7 KUN53895.1 KUN53895.1 KUN53964.1 KUN53964.1 DgkA DgkA PlsC4 PlsC4 PgsA2 PgsA2 pdxS pdxS PdxT PdxT apt apt relA relA pyrB pyrB pyrC pyrC KUN53595.1 KUN53595.1 carA carA carB carB pyrD pyrD pyrF pyrF gmk gmk Dfp Dfp GuaB3 GuaB3 KUN53553.1 KUN53553.1 AcsA2 AcsA2 nadE nadE PhoC PhoC nadA nadA PlsC3 PlsC3 thiG thiG ThiS ThiS GoxB GoxB ThiE ThiE coaE coaE KUN54212.1 KUN54212.1 tpiA tpiA AQJ43_11925 AQJ43_11925 moaA moaA PpnK1 PpnK1 ClsA ClsA KUN54808.1 KUN54808.1 KUN55393.1 KUN55393.1 Add1 Add1 KUN55372.1 KUN55372.1 KUN55255.1 KUN55255.1 PlsC1 PlsC1 dxs1 dxs1 KUN55574.1 KUN55574.1 HopB HopB PgsA5 PgsA5 KUN55563.1 KUN55563.1 idi idi KUN55961.1 KUN55961.1 KUN55915.1 KUN55915.1 fdhD fdhD KUN55842.1 KUN55842.1 psd psd PssA PssA hyuA hyuA AcsA4 AcsA4 pdxH pdxH PdxH2 PdxH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
KUN57164.1Sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
MoaA1Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (440 aa)
moaCCyclic pyranopterin monophosphate synthase accessory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
MoaBMolybdenum cofactor biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (297 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
glmUBifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (463 aa)
guaAGMP synthetase; Contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
FolD1THF_DHG_CYH domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
KUN56596.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
Add3Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
KUN56539.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
CyaAAdenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
MoaEMolybdopterin biosynthesis protein MoeE; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
nrdBRibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (337 aa)
KUN56238.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
IdsBPolyprenyl synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (394 aa)
PtlBDimethylallyltranstransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (337 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (269 aa)
atpEATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa)
atpFATP synthase F0F1 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (180 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (273 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (529 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (478 aa)
atpCATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (601 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (417 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (88 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (234 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (752 aa)
purFAmidophosphoribosyltransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
PurMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
KUN52435.1Glycerol acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
Add4Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AdkAdenylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
Ino1Inositol-3-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
coaAType I pantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (502 aa)
GuaB2Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
KUN52379.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (383 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
KUN52322.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
nadDNicotinate-nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (224 aa)
KUN52282.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
KUN51923.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (190 aa)
PncANicotinamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
PncBNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (442 aa)
KUN51817.1Peptidase M6; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
GptAPhosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
KUN51695.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (394 aa)
KUN51565.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
KUN51593.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
AcsA1Acetyl-coenzyme A synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (652 aa)
HprTHypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
folEGTP cyclohydrolase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
NadBL-aspartate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
NadCNicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (328 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa)
PlsC2Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (336 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (320 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (252 aa)
CdsAPhosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family. (284 aa)
KUN51182.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
KUN51257.1Hypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (245 aa)
KUN51282.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
KUN50946.1VlmB-like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
KUN50958.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
dxs21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
KUN50820.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa)
PgsA4Phosphatidylglycerophosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (323 aa)
AcsA3acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
KUN50759.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (79 aa)
KUN50680.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
PgsA1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (282 aa)
CinADamage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (181 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (175 aa)
AccD3acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
MoaDMolybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (250 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (174 aa)
KUN50077.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
KUN50092.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
PrsA2Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
Dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
RibFBifunctional riboflavin kinase/FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (311 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
folD_2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
CdhHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
KUN49110.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
KUN47763.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
KUN47764.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
KUN47772.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
KUN47262.1Guanylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
BkdAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
MobAMolybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (295 aa)
MoaA2Molybdenum cofactor biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (464 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
PgsA3CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (202 aa)
PurBAdenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (479 aa)
PlsC6Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
KUN53095.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
thiDHydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
PlsC7-2Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
AvsASiderophore biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ppnKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (549 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
PlsC7Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
KUN53895.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
KUN53964.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
DgkASphingosine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
PlsC4Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
PgsA2CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (304 aa)
PdxTGlutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (845 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (325 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
KUN53595.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (380 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1102 aa)
pyrDDihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (280 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (197 aa)
DfpPhosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
GuaB3Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
KUN53553.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
AcsA2acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (584 aa)
PhoCAcid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
PlsC3Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
ThiSThiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
GoxBGlycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ThiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (215 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (205 aa)
KUN54212.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
AQJ43_11925VOC domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
moaACyclic pyranopterin phosphate synthase MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
PpnK1NAD kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
ClsACardiolipin synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
KUN54808.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
KUN55393.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
Add1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
KUN55372.1acyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
KUN55255.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
PlsC1Glycerol acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
dxs11-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
KUN55574.11-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
HopBDimethylallyltranstransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (355 aa)
PgsA5Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
KUN55563.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (599 aa)
idiIsopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (197 aa)
KUN55961.1ATP-grasp domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
KUN55915.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (240 aa)
fdhDFormate dehydrogenase accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (282 aa)
KUN55842.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (159 aa)
PssAPhosphatidylserine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (272 aa)
hyuAPhenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
AcsA4AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (224 aa)
PdxH2Oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
Server load: low (10%) [HD]