38 items (Streptomyces avermitilis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PrpM3	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (933 aa)
	KUN56519.1	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
	PrpJ6	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
	KUN57066.1	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
	KUN55629.1	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
	KUN55820.1	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (820 aa)
	KUN54965.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
	KUN55157.1	Diguanylate phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
	PrpJ5	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (804 aa)
	KUN55312.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
	PrpB5	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
	KUN54795.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1424 aa)
	KUN54822.1	Antitermination regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
	PrpJ4	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
	KUN54018.1	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	PrpM5	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (699 aa)
	PrpL3	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (785 aa)
	PrpM4	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (690 aa)
	KUN53234.1	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
	PrpJ7	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (794 aa)
	PrpE3	Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
	KUN52946.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
	PrpC6	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (922 aa)
	KUN52316.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1357 aa)
	KUN51633.1	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
	PrpJ2	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (675 aa)
	PrpJ3	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (909 aa)
	PrpC4	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (785 aa)
	PrpD	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (707 aa)
	PrpM1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (808 aa)
	PrpL1	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (820 aa)
	PrpJ1	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (770 aa)
	OsaC	PAS domain S-box protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (873 aa)
	OsaA	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1797 aa)
	KUN50360.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
	PrpC7	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (847 aa)
	PrpJ8	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (715 aa)
	PrpL4	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (797 aa)

Your Current Organism:

Streptomyces avermitilis

NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KUN50360.1	KUN52316.1	AQJ43_32935	AQJ43_23495	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.782
KUN50360.1	OsaA	AQJ43_32935	AQJ43_32050	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.935
KUN51633.1	KUN52316.1	AQJ43_27050	AQJ43_23495	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.593
KUN51633.1	OsaA	AQJ43_27050	AQJ43_32050	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.634
KUN52316.1	KUN50360.1	AQJ43_23495	AQJ43_32935	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.782
KUN52316.1	KUN51633.1	AQJ43_23495	AQJ43_27050	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.593
KUN52316.1	KUN52946.1	AQJ43_23495	AQJ43_20815	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.782
KUN52316.1	KUN54018.1	AQJ43_23495	AQJ43_11670	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.782
KUN52316.1	KUN54795.1	AQJ43_23495	AQJ43_11080	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.888
KUN52316.1	KUN54822.1	AQJ43_23495	AQJ43_11235	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antitermination regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.661
KUN52316.1	KUN54965.1	AQJ43_23495	AQJ43_08375	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.645
KUN52316.1	KUN55157.1	AQJ43_23495	AQJ43_09450	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.608
KUN52316.1	KUN55312.1	AQJ43_23495	AQJ43_10300	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.646
KUN52316.1	KUN55820.1	AQJ43_23495	AQJ43_06985	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.795
KUN52316.1	KUN56519.1	AQJ43_23495	AQJ43_02655	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.938
KUN52316.1	KUN57066.1	AQJ43_23495	AQJ43_05775	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
KUN52316.1	OsaA	AQJ43_23495	AQJ43_32050	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KUN52316.1	OsaC	AQJ43_23495	AQJ43_32045	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain S-box protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.935
KUN52316.1	PrpB5	AQJ43_23495	AQJ43_10810	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.457
KUN52316.1	PrpC4	AQJ43_23495	AQJ43_29345	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.988

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