STRINGSTRING
AQJ43_32035 AQJ43_32035 DndA DndA AspB2 AspB2 KUN56372.1 KUN56372.1 AspB3 AspB3 MetB MetB glyA_1 glyA_1 rocD rocD KUN53209.1 KUN53209.1 gcvP gcvP cysA cysA pat pat KUN52970.1 KUN52970.1 hemL hemL AspC1 AspC1 SidD SidD DapC DapC kynU kynU KUN51570.1 KUN51570.1 GadB2 GadB2 KUN51684.1 KUN51684.1 glyA_1-2 glyA_1-2 KUN51349.1 KUN51349.1 KUN51485.1 KUN51485.1 KUN51251.1 KUN51251.1 RocD3 RocD3 glyA_2 glyA_2 KUN50515.1 KUN50515.1 GabT GabT KUN56609.1 KUN56609.1 GadB1 GadB1 KUN56902.1 KUN56902.1 serC serC AspB1 AspB1 KUN55775.1 KUN55775.1 KUN55850.1 KUN55850.1 KUN54951.1 KUN54951.1 kbl kbl LtaA LtaA KUN54816.1 KUN54816.1 KUN54886.1 KUN54886.1 CobC CobC AspC2 AspC2 ectB ectB KUN54217.1 KUN54217.1 hisC hisC KUN54386.1 KUN54386.1 KUN54397.1 KUN54397.1 KUN54655.1 KUN54655.1 KUN53498.1 KUN53498.1 KUN53538.1 KUN53538.1 argD argD KUN53703.1 KUN53703.1 KUN53035.1 KUN53035.1 KUN53237.1 KUN53237.1 rocD-2 rocD-2 BioF BioF BioA BioA KUN53247.1 KUN53247.1 Mgl Mgl csd csd KUN54088.1 KUN54088.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQJ43_32035Uncharacterized protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (220 aa)
DndACysteine desulfurase DndA; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AspB2Succinyldiaminopimelate transaminase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
KUN56372.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AspB3Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
MetBCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
glyA_1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa)
rocDOrnithine--oxo-acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
KUN53209.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
cysACystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
KUN52970.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
AspC1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
SidDPyridoxal-dependent decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
DapCAminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (394 aa)
KUN51570.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
GadB2Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (470 aa)
KUN51684.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
glyA_1-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
KUN51349.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
KUN51485.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
KUN51251.1NTD biosynthesis operon protein NtdA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (449 aa)
RocD3Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
glyA_2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
KUN50515.12,4-diaminobutyrate 4-aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
GabT4-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
KUN56609.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
GadB1Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (454 aa)
KUN56902.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (413 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AspB1Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
KUN55775.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
KUN55850.1Aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
KUN54951.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
LtaAThreonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
KUN54816.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
KUN54886.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
CobCAminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
AspC2Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
ectBDiaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
KUN54217.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
hisCAspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa)
KUN54386.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
KUN54397.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sulfur carrier protein TusA family. (460 aa)
KUN54655.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
KUN53498.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
KUN53538.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
argDAcetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa)
KUN53703.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
KUN53035.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
KUN53237.14-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa)
rocD-2Ornithine--oxo-acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa)
BioF8-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
BioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
KUN53247.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
MglCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
csdCysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
KUN54088.1Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
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