(23 nodes) Selenocompound metabolism network (Lysinibacillus macroides)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOY82981.1	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
	KOY83315.1	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
	KOY83316.1	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
	KOY83389.1	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
	KOY82069.1	Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
	sat	ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
	KOY82132.1	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (409 aa)
	KOY83046.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
	KOY80891.1	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
	metE	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (763 aa)
	KOY81900.1	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (405 aa)
	KOY81803.1	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
	KOY81737.1	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1143 aa)
	KOY81736.1	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
	KOY82199.1	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
	KOY84144.1	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
	KOY83788.1	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
	KOY82492.1	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
	KOY82146.1	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	KOY82138.1	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
	metG	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (658 aa)
	KOY80274.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
	KOY80230.1	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)

Your Current Organism:

Lysinibacillus macroides

NCBI taxonomy Id: 33935
Other names: ATCC 12905, Bacillus macroides, DSM 54, L. macroides, LMG 18474, LMG:18474, Lineola longa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOY80230.1	KOY80891.1	ADM90_20455	ADM90_17105	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80230.1	KOY81803.1	ADM90_20455	ADM90_12875	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.692
KOY80230.1	KOY82138.1	ADM90_20455	ADM90_10855	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80230.1	KOY82146.1	ADM90_20455	ADM90_10895	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80230.1	KOY82492.1	ADM90_20455	ADM90_03900	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.692
KOY80274.1	KOY81736.1	ADM90_20715	ADM90_12480	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.592
KOY80274.1	KOY81737.1	ADM90_20715	ADM90_12485	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.593
KOY80274.1	KOY83315.1	ADM90_20715	ADM90_08580	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.467
KOY80274.1	KOY83316.1	ADM90_20715	ADM90_08585	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468
KOY80891.1	KOY80230.1	ADM90_17105	ADM90_20455	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80891.1	KOY81737.1	ADM90_17105	ADM90_12485	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.612
KOY80891.1	KOY82199.1	ADM90_17105	ADM90_11210	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80891.1	KOY82981.1	ADM90_17105	ADM90_06600	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80891.1	KOY83046.1	ADM90_17105	ADM90_06990	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80891.1	KOY83788.1	ADM90_17105	ADM90_02500	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY80891.1	KOY84144.1	ADM90_17105	ADM90_01685	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
KOY81736.1	KOY80274.1	ADM90_12480	ADM90_20715	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.592
KOY81736.1	KOY81737.1	ADM90_12480	ADM90_12485	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.999
KOY81736.1	KOY81900.1	ADM90_12480	ADM90_13420	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	0.513
KOY81736.1	KOY82069.1	ADM90_12480	ADM90_10490	Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.894