(63 nodes) Mixed, incl. Serine hydrolase activity, and Arachidonic acid metabolism network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00037	Vacuolar protease A; Belongs to the peptidase A1 family. (398 aa)
	HCAG_00227	Uncharacterized protein. (358 aa)
	HCAG_00228	Uncharacterized protein. (301 aa)
	HCAG_00443	Peptidase_S8 domain-containing protein. (682 aa)
	HCAG_00635	Subtilase-type proteinase psp3. (495 aa)
	HCAG_00653	Aa_trans domain-containing protein. (533 aa)
	HCAG_00654	Uncharacterized protein; Belongs to the BI1 family. (187 aa)
	HCAG_01851	Uncharacterized protein. (439 aa)
	HCAG_01863	Uncharacterized protein. (480 aa)
	HCAG_01940	Carboxypeptidase; Belongs to the peptidase S10 family. (490 aa)
	HCAG_01941	Uncharacterized protein; Belongs to the peptidase S10 family. (213 aa)
	KEX1	Pheromone-processing carboxypeptidase KEX1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). (634 aa)
	HCAG_02879	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (472 aa)
	HCAG_02934	Uncharacterized protein. (842 aa)
	HCAG_03040	SMI1_KNR4 domain-containing protein. (389 aa)
	HCAG_03199	Uncharacterized protein. (687 aa)
	HCAG_03204	Uncharacterized protein. (149 aa)
	HCAG_03557	HAD_SAK_1 domain-containing protein. (586 aa)
	HCAG_03558	RING-type domain-containing protein. (384 aa)
	HCAG_03603	RING-type domain-containing protein. (562 aa)
	HCAG_03639	TRP_N domain-containing protein. (365 aa)
	HCAG_03811	Uncharacterized protein. (166 aa)
	HCAG_04060	Uncharacterized protein. (2053 aa)
	HCAG_04154	Uncharacterized protein. (754 aa)
	HCAG_04165	Uncharacterized protein. (560 aa)
	HCAG_04229	Uncharacterized protein. (287 aa)
	HCAG_04508	Uncharacterized protein; Belongs to the peptidase S10 family. (522 aa)
	HCAG_04953	Uncharacterized protein. (714 aa)
	HCAG_05077	Uncharacterized protein. (387 aa)
	HCAG_05245	Rhomboid protein 2. (146 aa)
	HCAG_05276	Uncharacterized protein. (290 aa)
	HCAG_05284	SprT-like domain-containing protein. (852 aa)
	HCAG_05368	RING-type domain-containing protein. (892 aa)
	MCA1	Metacaspase-1; Involved in cell death (apoptosis). (356 aa)
	HCAG_05605	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (487 aa)
	HCAG_05611	Uncharacterized protein. (444 aa)
	HCAG_06550	Abhydrolase_2 domain-containing protein. (419 aa)
	HCAG_06860	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (508 aa)
	HCAG_06976	Glycos_transf_1 domain-containing protein. (737 aa)
	HCAG_05789	SSD domain-containing protein. (1181 aa)
	HCAG_05950	Carboxypeptidase; Belongs to the peptidase S10 family. (653 aa)
	HCAG_06003	Proteinase T; Belongs to the peptidase S8 family. (402 aa)
	HCAG_06222	Uncharacterized protein. (462 aa)
	HCAG_07015	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (851 aa)
	HCAG_07050	TRP domain-containing protein. (412 aa)
	HCAG_07051	TRP domain-containing protein. (196 aa)
	HCAG_07217	Uncharacterized protein. (113 aa)
	HCAG_07218	BHLH domain-containing protein. (796 aa)
	HCAG_07300	CFEM domain-containing protein. (219 aa)
	HCAG_07391	Uncharacterized protein. (501 aa)
	HCAG_07553	Mannan endo-1,6-alpha-mannosidase. (448 aa)
	HCAG_07654	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (872 aa)
	HCAG_07655	Uncharacterized protein. (270 aa)
	HCAG_07776	Sphingolipid long chain base-responsive protein PIL1. (355 aa)
	HCAG_07835	Uncharacterized protein. (618 aa)
	HCAG_08634	Uncharacterized protein. (412 aa)
	HCAG_08635	Uncharacterized protein. (178 aa)
	NMA111	Pro-apoptotic serine protease NMA111; Nuclear serine protease which mediates apoptosis. Belongs to the peptidase S1C family. (1028 aa)
	HCAG_08652	Uncharacterized protein. (268 aa)
	CPYA	Carboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). (545 aa)
	HCAG_08679	RING-type domain-containing protein. (569 aa)
	HCAG_08879	MARVEL domain-containing protein. (152 aa)
	HCAG_08968	Uncharacterized protein. (322 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPYA	HCAG_00037	A6RGA0	A6QRN1	Carboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).	Vacuolar protease A; Belongs to the peptidase A1 family.	0.430
CPYA	HCAG_05605	A6RGA0	A6R7J7	Carboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.430
HCAG_00037	CPYA	A6QRN1	A6RGA0	Vacuolar protease A; Belongs to the peptidase A1 family.	Carboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).	0.430
HCAG_00037	HCAG_00227	A6QRN1	A6QS71	Vacuolar protease A; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.501
HCAG_00037	HCAG_00635	A6QRN1	A6QTC9	Vacuolar protease A; Belongs to the peptidase A1 family.	Subtilase-type proteinase psp3.	0.646
HCAG_00037	HCAG_02934	A6QRN1	A6QZX7	Vacuolar protease A; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.432
HCAG_00037	HCAG_03811	A6QRN1	A6R2F3	Vacuolar protease A; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.430
HCAG_00037	HCAG_06003	A6QRN1	A6RAL5	Vacuolar protease A; Belongs to the peptidase A1 family.	Proteinase T; Belongs to the peptidase S8 family.	0.432
HCAG_00037	HCAG_07015	A6QRN1	A6RBK7	Vacuolar protease A; Belongs to the peptidase A1 family.	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.419
HCAG_00037	KEX1	A6QRN1	A6QX86	Vacuolar protease A; Belongs to the peptidase A1 family.	Pheromone-processing carboxypeptidase KEX1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).	0.425
HCAG_00227	HCAG_00037	A6QS71	A6QRN1	Uncharacterized protein.	Vacuolar protease A; Belongs to the peptidase A1 family.	0.501
HCAG_00227	HCAG_00228	A6QS71	A6QS72	Uncharacterized protein.	Uncharacterized protein.	0.900
HCAG_00227	HCAG_02879	A6QS71	A6QZS2	Uncharacterized protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.501
HCAG_00227	HCAG_05605	A6QS71	A6R7J7	Uncharacterized protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.501
HCAG_00227	HCAG_06550	A6QS71	A6R8A9	Uncharacterized protein.	Abhydrolase_2 domain-containing protein.	0.501
HCAG_00227	HCAG_06860	A6QS71	A6R969	Uncharacterized protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.501
HCAG_00227	HCAG_07015	A6QS71	A6RBK7	Uncharacterized protein.	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.625
HCAG_00228	HCAG_00227	A6QS72	A6QS71	Uncharacterized protein.	Uncharacterized protein.	0.900
HCAG_00635	HCAG_00037	A6QTC9	A6QRN1	Subtilase-type proteinase psp3.	Vacuolar protease A; Belongs to the peptidase A1 family.	0.646
HCAG_00653	HCAG_00654	A6QTE7	A6QTE8	Aa_trans domain-containing protein.	Uncharacterized protein; Belongs to the BI1 family.	0.522