(52 nodes) Mixed, incl. Deadenylation-dependent mRNA decay, and NUDIX hydrolase domain network (Histoplasma capsulatum NAm1)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HCAG_00093	SurE domain-containing protein. (1146 aa)
	HCAG_00094	Uncharacterized protein. (2348 aa)
	HCAG_00485	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1327 aa)
	HCAG_00686	AB hydrolase-1 domain-containing protein. (240 aa)
	HCAG_00737	YjeF N-terminal domain-containing protein. (182 aa)
	HCAG_00907	Nudix hydrolase domain-containing protein. (327 aa)
	HCAG_00954	Uncharacterized protein. (803 aa)
	HCAG_01455	HTH La-type RNA-binding domain-containing protein. (1134 aa)
	HCAG_01697	Cell differentiation protein Rcd1. (422 aa)
	HCAG_01714	Protein mmf1, mitochondrial. (129 aa)
	HCAG_01730	Uncharacterized protein. (607 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (547 aa)
	HCAG_02332	Sm domain-containing protein. (171 aa)
	HCAG_02489	Uncharacterized protein. (761 aa)
	HCAG_02536	Uncharacterized protein. (794 aa)
	HCAG_02705	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (253 aa)
	HCAG_02845	Uncharacterized protein. (219 aa)
	HCAG_02880	CCR4-NOT transcription complex subunit 7. (444 aa)
	HCAG_02966	Uncharacterized protein. (354 aa)
	HCAG_03450	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
	HCAG_03934	Uncharacterized protein. (251 aa)
	HCAG_03935	Uncharacterized protein. (371 aa)
	DED1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (694 aa)
	HCAG_04287	Nudix hydrolase domain-containing protein. (313 aa)
	HCAG_04288	Letm1 RBD domain-containing protein. (538 aa)
	HCAG_04397	Uncharacterized protein. (114 aa)
	HCAG_04497	Nudix hydrolase domain-containing protein. (303 aa)
	HCAG_04498	40S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. (88 aa)
	CDC123	Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family. (424 aa)
	HCAG_05362	Uncharacterized protein. (640 aa)
	HCAG_05426	Uncharacterized protein. (699 aa)
	HCAG_05532	Uncharacterized protein. (393 aa)
	STS1	Tethering factor for nuclear proteasome STS1; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity). (312 aa)
	HCAG_05762	Uncharacterized protein. (765 aa)
	HCAG_05763	Uncharacterized protein. (676 aa)
	HCAG_05934	Nudix hydrolase domain-containing protein. (152 aa)
	HCAG_06026	Polyadenylate-binding protein. (732 aa)
	HCAG_06068	Endo/exonuclease/phosphatase domain-containing protein. (769 aa)
	HCAG_07334	Uncharacterized protein. (717 aa)
	MRH4	ATP-dependent RNA helicase MRH4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (624 aa)
	HCAG_07827	CUE domain-containing protein. (197 aa)
	HCAG_07833	NOT2_3_5 domain-containing protein. (449 aa)
	HCAG_08405	Nudix hydrolase domain-containing protein. (299 aa)
	HCAG_08406	ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. (227 aa)
	HCAG_08663	Uncharacterized protein. (744 aa)
	HCAG_08701	Uncharacterized protein. (277 aa)
	HCAG_08827	Exonuclease domain-containing protein. (661 aa)
	HCAG_08835	Uncharacterized protein. (613 aa)
	HCAG_08923	Uncharacterized protein. (532 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1163 aa)
	HCAG_09069	Uncharacterized protein; Belongs to the DEAD box helicase family. (457 aa)
	HCAG_09348	Helicase ATP-binding domain-containing protein. (178 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC123	HCAG_08405	A6R687	A6RFI9	Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family.	Nudix hydrolase domain-containing protein.	0.445
CDC123	HCAG_08406	A6R687	A6RFJ0	Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family.	ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family.	0.535
DED1	HCAG_00954	A6R3L3	A6QU98	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.431
DED1	HCAG_01730	A6R3L3	A6QWH3	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.434
DED1	HCAG_02332	A6R3L3	A6QY75	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Sm domain-containing protein.	0.425
DED1	HCAG_02966	A6R3L3	A6R009	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.445
DED1	HCAG_06026	A6R3L3	A6RAN8	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Polyadenylate-binding protein.	0.597
DED1	HCAG_09069	A6R3L3	A6RHF2	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.556
DED1	HCAG_09348	A6R3L3	A6XPM5	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Helicase ATP-binding domain-containing protein.	0.550
HCAG_00093	HCAG_00737	A6QRT7	A6QTN1	SurE domain-containing protein.	YjeF N-terminal domain-containing protein.	0.686
HCAG_00093	HCAG_02489	A6QRT7	A6QYN2	SurE domain-containing protein.	Uncharacterized protein.	0.686
HCAG_00093	HCAG_02966	A6QRT7	A6R009	SurE domain-containing protein.	Uncharacterized protein.	0.885
HCAG_00093	HCAG_08701	A6QRT7	A6RGD5	SurE domain-containing protein.	Uncharacterized protein.	0.823
HCAG_00094	HCAG_00485	A6QRT8	A6QSX9	Uncharacterized protein.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.601
HCAG_00094	HCAG_00954	A6QRT8	A6QU98	Uncharacterized protein.	Uncharacterized protein.	0.914
HCAG_00094	HCAG_01697	A6QRT8	A6QWE0	Uncharacterized protein.	Cell differentiation protein Rcd1.	0.998
HCAG_00094	HCAG_01730	A6QRT8	A6QWH3	Uncharacterized protein.	Uncharacterized protein.	0.505
HCAG_00094	HCAG_02880	A6QRT8	A6QZS3	Uncharacterized protein.	CCR4-NOT transcription complex subunit 7.	0.998
HCAG_00094	HCAG_02966	A6QRT8	A6R009	Uncharacterized protein.	Uncharacterized protein.	0.540
HCAG_00094	HCAG_05762	A6QRT8	A6R9X4	Uncharacterized protein.	Uncharacterized protein.	0.948