(26 nodes) KEAP1-NFE2L2 pathway, and Ubiquitin-dependent ERAD pathway network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00482	Uncharacterized protein. (692 aa)
	HCAG_00738	Uncharacterized protein. (788 aa)
	HCAG_01188	UBX domain-containing protein. (458 aa)
	HCAG_02080	Uncharacterized protein. (361 aa)
	HCAG_02333	AAA domain-containing protein. (367 aa)
	HCAG_02373	Uncharacterized protein. (823 aa)
	HCAG_02452	Cell division cycle protein 48; Belongs to the AAA ATPase family. (806 aa)
	HCAG_02770	Uncharacterized protein. (660 aa)
	HCAG_02977	DUF4203 domain-containing protein. (920 aa)
	HCAG_03048	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (280 aa)
	HCAG_03075	ATPase_AAA_core domain-containing protein. (662 aa)
	HCAG_03521	OTU domain-containing protein. (354 aa)
	HCAG_03965	AAA domain-containing protein. (914 aa)
	HCAG_04186	TUG-UBL1 domain-containing protein. (485 aa)
	NPL4	Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (642 aa)
	HCAG_05170	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (273 aa)
	HCAG_05567	U-box domain-containing protein. (1058 aa)
	HCAG_05614	Uncharacterized protein. (313 aa)
	HCAG_06392	UBX domain-containing protein. (591 aa)
	HCAG_07158	ATPase_AAA_core domain-containing protein. (632 aa)
	HCAG_07333	Uncharacterized protein. (1360 aa)
	HCAG_07661	Uncharacterized protein; Belongs to the AAA ATPase family. (672 aa)
	HCAG_07684	AZUL domain-containing protein. (810 aa)
	HCAG_07983	Rad4 domain-containing protein. (151 aa)
	HCAG_08503	Uncharacterized protein. (712 aa)
	HCAG_09312	PRKCSH domain-containing protein. (226 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00482	HCAG_00738	A6QSX6	A6QTN2	Uncharacterized protein.	Uncharacterized protein.	0.493
HCAG_00482	HCAG_01188	A6QSX6	A6QUY2	Uncharacterized protein.	UBX domain-containing protein.	0.466
HCAG_00482	HCAG_02080	A6QSX6	A6QXH3	Uncharacterized protein.	Uncharacterized protein.	0.459
HCAG_00482	HCAG_02770	A6QSX6	A6QZG3	Uncharacterized protein.	Uncharacterized protein.	0.489
HCAG_00482	HCAG_02977	A6QSX6	A6R020	Uncharacterized protein.	DUF4203 domain-containing protein.	0.459
HCAG_00482	HCAG_03048	A6QSX6	A6R091	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.504
HCAG_00482	HCAG_03521	A6QSX6	A6R1L3	Uncharacterized protein.	OTU domain-containing protein.	0.610
HCAG_00482	HCAG_04186	A6QSX6	A6R3H8	Uncharacterized protein.	TUG-UBL1 domain-containing protein.	0.490
HCAG_00482	HCAG_05170	A6QSX6	A6R6B2	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.504
HCAG_00482	HCAG_05567	A6QSX6	A6R7F9	Uncharacterized protein.	U-box domain-containing protein.	0.497
HCAG_00482	HCAG_05614	A6QSX6	A6R7K6	Uncharacterized protein.	Uncharacterized protein.	0.466
HCAG_00482	HCAG_06392	A6QSX6	A6R7V1	Uncharacterized protein.	UBX domain-containing protein.	0.636
HCAG_00482	HCAG_07684	A6QSX6	A6RDH6	Uncharacterized protein.	AZUL domain-containing protein.	0.459
HCAG_00482	HCAG_07983	A6QSX6	A6REB8	Uncharacterized protein.	Rad4 domain-containing protein.	0.491
HCAG_00482	HCAG_09312	A6QSX6	A6XPJ8	Uncharacterized protein.	PRKCSH domain-containing protein.	0.611
HCAG_00482	NPL4	A6QSX6	A6R538	Uncharacterized protein.	Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family.	0.650
HCAG_00738	HCAG_00482	A6QTN2	A6QSX6	Uncharacterized protein.	Uncharacterized protein.	0.493
HCAG_00738	HCAG_01188	A6QTN2	A6QUY2	Uncharacterized protein.	UBX domain-containing protein.	0.609
HCAG_00738	HCAG_02080	A6QTN2	A6QXH3	Uncharacterized protein.	Uncharacterized protein.	0.979
HCAG_00738	HCAG_02333	A6QTN2	A6QY76	Uncharacterized protein.	AAA domain-containing protein.	0.493