(130 nodes) Mixed, incl. MAPK signaling pathway - yeast, and GPCR downstream signalling network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00022	Uncharacterized protein. (268 aa)
	HCAG_00050	BZIP domain-containing protein. (511 aa)
	HCAG_00107	Uncharacterized protein. (197 aa)
	HCAG_00181	Protein kinase domain-containing protein. (343 aa)
	HCAG_00245	Uncharacterized protein. (1168 aa)
	HCAG_00261	Protein kinase domain-containing protein. (1058 aa)
	HCAG_00324	NodB homology domain-containing protein. (353 aa)
	HCAG_00396	PH domain-containing protein. (778 aa)
	HCAG_00480	Uncharacterized protein. (611 aa)
	HCAG_00507	Uncharacterized protein. (136 aa)
	HCAG_00675	Uncharacterized protein. (249 aa)
	HCAG_00714	Serine/threonine-protein kinase PRKX; Belongs to the protein kinase superfamily. (412 aa)
	HCAG_00716	CNH domain-containing protein. (105 aa)
	SHO1	High osmolarity signaling protein SHO1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (292 aa)
	HCAG_00732	Uncharacterized protein. (563 aa)
	HCAG_00742	Guanine nucleotide-binding protein alpha subunit. (353 aa)
	HCAG_00760	Uncharacterized protein. (243 aa)
	HCAG_00761	Uncharacterized protein. (279 aa)
	HCAG_00777	Uncharacterized protein. (1158 aa)
	HCAG_00842	Uncharacterized protein. (751 aa)
	HCAG_00894	Protein ras-1. (149 aa)
	HCAG_00982	Ubiquitin carboxyl-terminal hydrolase. (249 aa)
	HCAG_01053	Uncharacterized protein. (187 aa)
	HCAG_01152	Uncharacterized protein. (357 aa)
	HCAG_01182	Uncharacterized protein. (575 aa)
	HCAG_01183	Protein rho2. (199 aa)
	HCAG_01231	NIPSNAP domain-containing protein. (364 aa)
	HCAG_01241	Protein Rho3. (206 aa)
	HCAG_01357	Uncharacterized protein. (326 aa)
	HCAG_01374	Uncharacterized protein. (297 aa)
	HCAG_01471	BHLH domain-containing protein. (539 aa)
	HCAG_01561	Uncharacterized protein. (929 aa)
	HCAG_01720	Uncharacterized protein. (471 aa)
	HCAG_01783	Protein kinase domain-containing protein. (1381 aa)
	HCAG_01820	Uncharacterized protein. (193 aa)
	HCAG_01886	ELMO domain-containing protein. (720 aa)
	HCAG_01923	Uncharacterized protein. (588 aa)
	HCAG_02198	Uncharacterized protein. (261 aa)
	HCAG_02220	Protein kinase domain-containing protein. (668 aa)
	HCAG_02265	Protein kinase domain-containing protein. (172 aa)
	HCAG_02334	Uncharacterized protein. (675 aa)
	HCAG_02453	Uncharacterized protein. (435 aa)
	HCAG_02483	PPM-type phosphatase domain-containing protein. (629 aa)
	HCAG_02608	Guanine nucleotide-binding protein beta subunit. (287 aa)
	HCAG_02615	Uncharacterized protein. (417 aa)
	HCAG_02676	Uncharacterized protein. (410 aa)
	HCAG_02893	Uncharacterized protein. (1620 aa)
	HCAG_02974	Uncharacterized protein. (360 aa)
	HCAG_03019	Non-specific serine/threonine protein kinase. (881 aa)
	HCAG_03030	Uncharacterized protein. (634 aa)
	HCAG_03032	Uncharacterized protein. (656 aa)
	HCAG_03182	Protein kinase domain-containing protein. (1212 aa)
	HCAG_03218	Uncharacterized protein. (608 aa)
	HCAG_03260	Protein kinase domain-containing protein. (298 aa)
	HCAG_03368	VWFA domain-containing protein. (759 aa)
	HCAG_03461	Protein kinase byr1. (541 aa)
	HCAG_03498	Uncharacterized protein. (335 aa)
	HCAG_03570	G protein gamma domain-containing protein. (72 aa)
	HCAG_03572	Phosphodiesterase. (839 aa)
	HCAG_03588	Uncharacterized protein. (758 aa)
	HCAG_03617	Uncharacterized protein. (930 aa)
	HCAG_03754	Uncharacterized protein. (1014 aa)
	HCAG_03755	Uncharacterized protein. (288 aa)
	HCAG_03889	cAMP-dependent protein kinase type 2. (368 aa)
	HCAG_04003	Protein kinase domain-containing protein. (715 aa)
	HCAG_04004	Uncharacterized protein. (379 aa)
	HCAG_04061	Uncharacterized protein. (280 aa)
	HCAG_04173	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (307 aa)
	HCAG_04338	SH3 domain-containing protein. (154 aa)
	HCAG_04352	Protein kinase domain-containing protein. (210 aa)
	HCAG_04353	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (343 aa)
	HCAG_04446	Uncharacterized protein. (240 aa)
	HCAG_04489	Uncharacterized protein. (642 aa)
	HCAG_04527	14-3-3 family protein ArtA; Belongs to the 14-3-3 family. (268 aa)
	HCAG_04612	ANK_REP_REGION domain-containing protein. (203 aa)
	HCAG_04842	Uncharacterized protein. (806 aa)
	HCAG_04920	Arrestin_C domain-containing protein. (379 aa)
	HCAG_04995	Guanine nucleotide-binding protein alpha-2 subunit. (314 aa)
	HCAG_05236	Protein kinase domain-containing protein. (369 aa)
	HCAG_05250	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	HCAG_05274	Uncharacterized protein. (206 aa)
	HCAG_05296	Ras-GAP domain-containing protein. (1390 aa)
	HCAG_05313	WSC domain-containing protein. (277 aa)
	HCAG_05347	Protein kinase domain-containing protein. (298 aa)
	HCAG_05464	Ras-GAP domain-containing protein. (424 aa)
	HCAG_05488	cAMP-dependent protein kinase regulatory subunit. (148 aa)
	HCAG_05557	Casein kinase I isoform gamma-1. (406 aa)
	HCAG_05560	Uncharacterized protein. (192 aa)
	HCAG_05579	Uncharacterized protein. (446 aa)
	HCAG_06365	Rho-GAP domain-containing protein. (605 aa)
	HCAG_06408	Uncharacterized protein. (159 aa)
	HCAG_06440	Uncharacterized protein. (1201 aa)
	HCAG_06560	PHB domain-containing protein. (356 aa)
	HCAG_06589	Protein kinase domain-containing protein. (1438 aa)
	HCAG_06922	Integrase_H2C2 domain-containing protein. (401 aa)
	HCAG_06933	Uncharacterized protein. (149 aa)
	HCAG_06031	Uncharacterized protein. (98 aa)
	HCAG_06041	Uncharacterized protein; Belongs to the DOCK family. (1780 aa)
	HCAG_06099	HPt domain-containing protein. (106 aa)
	HCAG_06135	Uncharacterized protein. (799 aa)
	HCAG_06159	E3 ubiquitin-protein ligase. (883 aa)
	HCAG_06189	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (423 aa)
	HCAG_06305	Uncharacterized protein. (701 aa)
	HCAG_06320	Phosphoinositide phospholipase C. (660 aa)
	HCAG_07238	Uncharacterized protein. (160 aa)
	HCAG_07312	Uncharacterized protein. (327 aa)
	HCAG_07420	GTPase NRas. (184 aa)
	HCAG_07454	Uncharacterized protein. (152 aa)
	HCAG_07523	F-box domain-containing protein. (301 aa)
	HCAG_07549	Uncharacterized protein. (183 aa)
	HCAG_07554	MARVEL domain-containing protein. (168 aa)
	HCAG_07603	Protein kinase domain-containing protein. (224 aa)
	HCAG_07675	Uncharacterized protein. (912 aa)
	HCAG_07678	F-box domain-containing protein. (692 aa)
	HCAG_07848	Protein kinase domain-containing protein. (230 aa)
	HCAG_08014	Uncharacterized protein. (610 aa)
	HCAG_08451	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	HCAG_08454	Uncharacterized protein. (93 aa)
	HCAG_08463	Tyrosine-protein phosphatase domain-containing protein. (266 aa)
	HCAG_08498	Uncharacterized protein. (209 aa)
	HCAG_08552	Transcription factor steA. (556 aa)
	HCAG_08659	Uncharacterized protein. (823 aa)
	HCAG_08765	Uncharacterized protein. (757 aa)
	HCAG_08769	Uncharacterized protein. (540 aa)
	HCAG_08908	Opy2 domain-containing protein. (428 aa)
	HCAG_08982	Uncharacterized protein. (489 aa)
	HCAG_09016	Non-specific serine/threonine protein kinase. (904 aa)
	HCAG_09047	Uncharacterized protein. (898 aa)
	HCAG_09343	CNH domain-containing protein. (175 aa)
	HCAG_09346	Uncharacterized protein. (167 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00022	HCAG_00777	A6QRL6	A6QTS1	Uncharacterized protein.	Uncharacterized protein.	0.460
HCAG_00022	HCAG_04173	A6QRL6	A6R3G5	Uncharacterized protein.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.406
HCAG_00022	HCAG_04527	A6QRL6	A6R4G9	Uncharacterized protein.	14-3-3 family protein ArtA; Belongs to the 14-3-3 family.	0.406
HCAG_00022	HCAG_04612	A6QRL6	A6R4Q4	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.461
HCAG_00022	HCAG_05347	A6QRL6	A6R6T9	Uncharacterized protein.	Protein kinase domain-containing protein.	0.588
HCAG_00022	HCAG_05579	A6QRL6	A6R7H1	Uncharacterized protein.	Uncharacterized protein.	0.410
HCAG_00022	HCAG_08765	A6QRL6	A6RGJ8	Uncharacterized protein.	Uncharacterized protein.	0.414
HCAG_00050	HCAG_03030	A6QRP4	A6R073	BZIP domain-containing protein.	Uncharacterized protein.	0.642
HCAG_00050	HCAG_03260	A6QRP4	A6R0V3	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.970
HCAG_00050	HCAG_04061	A6QRP4	A6R353	BZIP domain-containing protein.	Uncharacterized protein.	0.437
HCAG_00050	HCAG_05236	A6QRP4	A6R6H8	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.970
HCAG_00050	HCAG_05250	A6QRP4	A6R6J2	BZIP domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.632
HCAG_00050	HCAG_06189	A6QRP4	A6RB51	BZIP domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.673
HCAG_00050	HCAG_08451	A6QRP4	A6RFN5	BZIP domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.974
HCAG_00107	HCAG_00245	A6QRV1	A6QS89	Uncharacterized protein.	Uncharacterized protein.	0.912
HCAG_00107	HCAG_00716	A6QRV1	A6QTL0	Uncharacterized protein.	CNH domain-containing protein.	0.650
HCAG_00107	HCAG_00742	A6QRV1	A6QTN6	Uncharacterized protein.	Guanine nucleotide-binding protein alpha subunit.	0.433
HCAG_00107	HCAG_00777	A6QRV1	A6QTS1	Uncharacterized protein.	Uncharacterized protein.	0.999
HCAG_00107	HCAG_00894	A6QRV1	A6QU38	Uncharacterized protein.	Protein ras-1.	0.446
HCAG_00107	HCAG_01053	A6QRV1	A6QUJ7	Uncharacterized protein.	Uncharacterized protein.	0.421