(27 nodes) Proton-transporting V-type ATPase complex, and Cation transporter network (Histoplasma capsulatum NAm1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	HCAG_00074	Uncharacterized protein. (526 aa)
	HCAG_00404	Vacuolar ATP synthase catalytic subunit A. (636 aa)
	HCAG_00715	Vacuolar ATP synthase 16 kDa proteolipid subunit 2. (95 aa)
	HCAG_01577	Uncharacterized protein. (565 aa)
	HCAG_01585	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (817 aa)
	HCAG_01743	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (401 aa)
	HCAG_02434	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (365 aa)
	HCAG_02640	Vacuolar ATP synthase subunit D. (260 aa)
	HCAG_02745	Uncharacterized protein. (264 aa)
	HCAG_03209	Vacuolar ATP synthase subunit E. (220 aa)
	HCAG_03440	V-ATPase_H_C domain-containing protein. (552 aa)
	HCAG_04307	Inorganic pyrophosphatase. (295 aa)
	VMA21	Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (108 aa)
	HCAG_04396	Uncharacterized protein. (1182 aa)
	HCAG_04422	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (115 aa)
	HCAG_04991	Uncharacterized protein. (631 aa)
	HCAG_04992	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (161 aa)
	HCAG_05307	Potassium transport protein; Belongs to the TrkH potassium transport family. (711 aa)
	HCAG_05395	Uncharacterized protein. (334 aa)
	HCAG_06355	Uncharacterized protein. (524 aa)
	HCAG_06977	Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (910 aa)
	HCAG_05951	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa)
	HCAG_07080	Uncharacterized protein. (197 aa)
	HCAG_07109	Uncharacterized protein. (70 aa)
	HCAG_07130	NAD_binding_2 domain-containing protein. (300 aa)
	HCAG_09267	Uncharacterized protein. (88 aa)
	HCAG_09313	Uncharacterized protein. (283 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00074	HCAG_00404	A6QRR8	A6QSP8	Uncharacterized protein.	Vacuolar ATP synthase catalytic subunit A.	0.527
HCAG_00074	HCAG_01585	A6QRR8	A6QW28	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.530
HCAG_00074	HCAG_02434	A6QRR8	A6QYH7	Uncharacterized protein.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.526
HCAG_00074	HCAG_02640	A6QRR8	A6QZ33	Uncharacterized protein.	Vacuolar ATP synthase subunit D.	0.527
HCAG_00074	HCAG_05951	A6QRR8	A6RAG3	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.517
HCAG_00074	HCAG_07109	A6QRR8	A6RBV1	Uncharacterized protein.	Uncharacterized protein.	0.516
HCAG_00404	HCAG_00074	A6QSP8	A6QRR8	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.527
HCAG_00404	HCAG_00715	A6QSP8	A6QTK9	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase 16 kDa proteolipid subunit 2.	0.981
HCAG_00404	HCAG_01585	A6QSP8	A6QW28	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
HCAG_00404	HCAG_01743	A6QSP8	A6QWI6	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.998
HCAG_00404	HCAG_02434	A6QSP8	A6QYH7	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.999
HCAG_00404	HCAG_02640	A6QSP8	A6QZ33	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase subunit D.	0.999
HCAG_00404	HCAG_03209	A6QSP8	A6R0Q2	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase subunit E.	0.999
HCAG_00404	HCAG_03440	A6QSP8	A6R1D3	Vacuolar ATP synthase catalytic subunit A.	V-ATPase_H_C domain-containing protein.	0.998
HCAG_00404	HCAG_04307	A6QSP8	A6R3U9	Vacuolar ATP synthase catalytic subunit A.	Inorganic pyrophosphatase.	0.804
HCAG_00404	HCAG_04422	A6QSP8	A6R464	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
HCAG_00404	HCAG_04991	A6QSP8	A6R5T3	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.982
HCAG_00404	HCAG_04992	A6QSP8	A6R5T4	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.982
HCAG_00404	HCAG_05307	A6QSP8	A6R6P9	Vacuolar ATP synthase catalytic subunit A.	Potassium transport protein; Belongs to the TrkH potassium transport family.	0.527
HCAG_00404	HCAG_05395	A6QSP8	A6R6Y7	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.444