(61 nodes) COPI-mediated anterograde transport, and SNAP receptor activity network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00077	Uncharacterized protein. (498 aa)
	HCAG_00180	Vps54 domain-containing protein. (342 aa)
	HCAG_00416	Uncharacterized protein. (1054 aa)
	HCAG_00446	t-SNARE coiled-coil homology domain-containing protein. (267 aa)
	HCAG_00515	Uncharacterized protein; Belongs to the EMP24/GP25L family. (605 aa)
	HCAG_00550	COG2 domain-containing protein. (321 aa)
	HCAG_00743	Uncharacterized protein. (145 aa)
	HCAG_01011	Uncharacterized protein. (65 aa)
	HCAG_01326	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (335 aa)
	HCAG_01401	t-SNARE coiled-coil homology domain-containing protein. (173 aa)
	HCAG_01445	Uncharacterized protein. (990 aa)
	HCAG_01675	t-SNARE coiled-coil homology domain-containing protein. (227 aa)
	HCAG_01814	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (956 aa)
	HCAG_01831	GOLD domain-containing protein. (70 aa)
	HCAG_01847	ADP-ribosylation factor. (723 aa)
	HCAG_01857	Uncharacterized protein. (303 aa)
	HCAG_02134	Uncharacterized protein. (224 aa)
	POA1	ADP-ribose 1''-phosphate phosphatase; Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing; Belongs to the POA1 family. (254 aa)
	HCAG_02251	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (516 aa)
	HCAG_02643	SEC7 domain-containing protein. (1407 aa)
	HCAG_02915	Arf-GAP domain-containing protein. (382 aa)
	HCAG_03133	Uncharacterized protein. (97 aa)
	HCAG_03414	Uncharacterized protein. (209 aa)
	HCAG_03439	TMF_TATA_bd domain-containing protein. (864 aa)
	HCAG_03663	Cog4 domain-containing protein. (858 aa)
	HCAG_03691	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (202 aa)
	HCAG_03779	Uncharacterized protein. (292 aa)
	HCAG_03812	Uncharacterized protein. (806 aa)
	HCAG_03970	Uncharacterized protein. (334 aa)
	HCAG_03973	SEC7 domain-containing protein. (1905 aa)
	HCAG_04212	Uncharacterized protein. (804 aa)
	HCAG_04305	Uncharacterized protein. (194 aa)
	HCAG_04345	Uncharacterized protein. (271 aa)
	HCAG_04366	Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
	HCAG_04628	t-SNARE coiled-coil homology domain-containing protein. (426 aa)
	HCAG_04857	Uncharacterized protein. (1321 aa)
	HCAG_05074	Synaptobrevin. (118 aa)
	HCAG_05133	Uncharacterized protein. (721 aa)
	HCAG_05142	Protein transport protein sec22; Belongs to the synaptobrevin family. (215 aa)
	COG6	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family. (645 aa)
	HCAG_05330	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (886 aa)
	HCAG_05448	Uncharacterized protein. (221 aa)
	HCAG_05563	GOLD domain-containing protein. (180 aa)
	HCAG_05598	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (270 aa)
	HCAG_06473	t-SNARE coiled-coil homology domain-containing protein. (355 aa)
	HCAG_06584	Uncharacterized protein. (804 aa)
	HCAG_06588	Uncharacterized protein. (754 aa)
	HCAG_06678	Vesicle-fusing ATPase. (805 aa)
	HCAG_06695	Uncharacterized protein. (931 aa)
	HCAG_06921	ER lumen protein-retaining receptor. (125 aa)
	HCAG_06022	Uncharacterized protein. (623 aa)
	HCAG_06246	DUF2263 domain-containing protein. (312 aa)
	HCAG_07033	GOLD domain-containing protein. (221 aa)
	HCAG_07503	V-SNARE coiled-coil homology domain-containing protein. (249 aa)
	HCAG_07936	t-SNARE coiled-coil homology domain-containing protein. (393 aa)
	HCAG_08067	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	HCAG_08186	Arf-GAP domain-containing protein. (481 aa)
	HCAG_08352	Uncharacterized protein; Belongs to the synaptobrevin family. (273 aa)
	HCAG_08438	Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (296 aa)
	HCAG_08724	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (846 aa)
	HCAG_08899	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (676 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COG6	HCAG_00077	A6R6L9	A6QRS1	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.998
COG6	HCAG_00180	A6R6L9	A6QS24	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Vps54 domain-containing protein.	0.746
COG6	HCAG_00416	A6R6L9	A6QSR0	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.746
COG6	HCAG_00446	A6R6L9	A6QSU0	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	t-SNARE coiled-coil homology domain-containing protein.	0.757
COG6	HCAG_00550	A6R6L9	A6QT44	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	COG2 domain-containing protein.	0.995
COG6	HCAG_01011	A6R6L9	A6QUF5	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.672
COG6	HCAG_01326	A6R6L9	A6QVB9	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.858
COG6	HCAG_01401	A6R6L9	A6QVJ4	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	t-SNARE coiled-coil homology domain-containing protein.	0.795
COG6	HCAG_01445	A6R6L9	A6QVN8	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.668
COG6	HCAG_01675	A6R6L9	A6QWB8	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	t-SNARE coiled-coil homology domain-containing protein.	0.814
COG6	HCAG_02134	A6R6L9	A6QXM7	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.747
COG6	HCAG_03133	A6R6L9	A6R0H6	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.692
COG6	HCAG_03414	A6R6L9	A6R1A7	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.849
COG6	HCAG_03439	A6R6L9	A6R1D2	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	TMF_TATA_bd domain-containing protein.	0.599
COG6	HCAG_03663	A6R6L9	A6R205	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Cog4 domain-containing protein.	0.995
COG6	HCAG_03779	A6R6L9	A6R2C1	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.666
COG6	HCAG_03812	A6R6L9	A6R2F4	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.656
COG6	HCAG_03970	A6R6L9	A6R2W2	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.759
COG6	HCAG_04212	A6R6L9	A6R3K4	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.522
COG6	HCAG_04305	A6R6L9	A6R3U7	Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.	Uncharacterized protein.	0.564