(64 nodes) Mixed, incl. Clathrin binding, and PhoX homologous domain, present in p47phox and p40phox. network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HCAG_00111	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (879 aa)
	HCAG_00157	AP-1 complex subunit gamma. (765 aa)
	HCAG_00171	Protein kinase domain-containing protein. (821 aa)
	HCAG_00204	Uncharacterized protein. (320 aa)
	HCAG_00240	PX domain-containing protein. (912 aa)
	TRM5	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (471 aa)
	HCAG_00288	WD_REPEATS_REGION domain-containing protein. (523 aa)
	HCAG_00403	Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (681 aa)
	HCAG_00494	GED domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (827 aa)
	HCAG_00573	Uncharacterized protein. (551 aa)
	HCAG_00598	AP-1 adaptor complex subunit mu; Belongs to the adaptor complexes medium subunit family. (422 aa)
	HCAG_00618	UBA domain-containing protein. (834 aa)
	HCAG_00869	Adaptin_N domain-containing protein. (753 aa)
	HCAG_00874	DUF1681 domain-containing protein. (353 aa)
	HCAG_00950	Rad60-SLD_2 domain-containing protein. (288 aa)
	HCAG_01103	ADP-ribosylation factor 6. (120 aa)
	HCAG_01154	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (152 aa)
	HCAG_01167	I/LWEQ domain-containing protein. (1031 aa)
	HCAG_01328	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (253 aa)
	HCAG_01489	Vacuolar protein sorting-associated protein 26. (287 aa)
	HCAG_01849	Uncharacterized protein. (371 aa)
	HCAG_01882	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (670 aa)
	VPS10	Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity); Belongs to the VPS10 family. (1477 aa)
	HCAG_02067	Uncharacterized protein. (1278 aa)
	HCAG_02345	Uncharacterized protein. (280 aa)
	HCAG_02455	PX domain-containing protein. (2014 aa)
	HCAG_02485	Uncharacterized protein. (743 aa)
	HCAG_02794	PX domain-containing protein. (294 aa)
	HCAG_02917	Vacuolar protein sorting-associated protein 17; Plays a role in vesicular protein sorting. Belongs to the VPS17 family. (581 aa)
	HCAG_02979	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (478 aa)
	HCAG_03470	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (905 aa)
	HCAG_03488	SEC7 domain-containing protein. (1655 aa)
	HCAG_04009	Sorting nexin-41. (630 aa)
	HCAG_04074	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (965 aa)
	HCAG_04225	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1631 aa)
	HCAG_04363	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (711 aa)
	HCAG_04492	ENTH domain-containing protein. (541 aa)
	HCAG_04546	Uncharacterized protein. (379 aa)
	HCAG_04547	GH16 domain-containing protein. (399 aa)
	HCAG_05039	Uncharacterized protein. (723 aa)
	HCAG_05220	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (186 aa)
	HCAG_05223	ENTH domain-containing protein. (447 aa)
	HCAG_05341	GED domain-containing protein. (670 aa)
	HCAG_05397	PH domain-containing protein. (1298 aa)
	HCAG_05521	Uncharacterized protein. (646 aa)
	HCAG_06724	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	HCAG_05712	GED domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (807 aa)
	HCAG_05731	VHS domain-containing protein. (404 aa)
	HCAG_05929	GH16 domain-containing protein. (380 aa)
	HCAG_05966	RING-type domain-containing protein. (721 aa)
	HCAG_06062	PX domain-containing protein. (356 aa)
	HCAG_06161	Uncharacterized protein. (103 aa)
	HCAG_07017	PX domain-containing protein. (462 aa)
	HCAG_07062	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (579 aa)
	HCAG_07240	Sorting nexin-3. (142 aa)
	HCAG_07263	Uncharacterized protein. (801 aa)
	HCAG_07315	SEC7 domain-containing protein. (656 aa)
	HCAG_07753	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (993 aa)
	HCAG_07842	Uncharacterized protein. (631 aa)
	HCAG_07987	ENTH domain-containing protein. (682 aa)
	HCAG_08087	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (692 aa)
	HCAG_08450	Uncharacterized protein. (738 aa)
	END3	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (405 aa)
	HCAG_08462	Uncharacterized protein. (844 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
END3	HCAG_00157	A6RFP4	A6QS01	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP-1 complex subunit gamma.	0.493
END3	HCAG_00171	A6RFP4	A6QS15	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Protein kinase domain-containing protein.	0.503
END3	HCAG_00874	A6RFP4	A6QU18	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	DUF1681 domain-containing protein.	0.487
END3	HCAG_00950	A6RFP4	A6QU94	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Rad60-SLD_2 domain-containing protein.	0.428
END3	HCAG_01167	A6RFP4	A6QUW1	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	I/LWEQ domain-containing protein.	0.543
END3	HCAG_01328	A6RFP4	A6QVC1	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.639
END3	HCAG_02067	A6RFP4	A6QXG0	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.665
END3	HCAG_02979	A6RFP4	A6R022	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.553
END3	HCAG_04074	A6RFP4	A6R366	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.493
END3	HCAG_04225	A6RFP4	A6R3L7	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.651
END3	HCAG_04363	A6RFP4	A6R405	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.428
END3	HCAG_04492	A6RFP4	A6R4D4	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.545
END3	HCAG_05223	A6RFP4	A6R6G5	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.634
END3	HCAG_06724	A6RFP4	A6R8T3	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.592
END3	HCAG_07263	A6RFP4	A6RCA5	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.506
END3	HCAG_07987	A6RFP4	A6REC2	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.539
END3	HCAG_08087	A6RFP4	A6REM2	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.428
END3	HCAG_08450	A6RFP4	A6RFN4	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.889
HCAG_00111	HCAG_00157	A6QRV5	A6QS01	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	AP-1 complex subunit gamma.	0.435
HCAG_00111	HCAG_00171	A6QRV5	A6QS15	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Protein kinase domain-containing protein.	0.429