(47 nodes) Biosynthesis of amino acids, and 3-isopropylmalate dehydrogenase activity network (Histoplasma capsulatum NAm1)

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second shell of interactors

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Predicted Interactions

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Your Input:
	HCAG_00014	Homoserine dehydrogenase. (370 aa)
	HCAG_00104	Acetolactate synthase. (610 aa)
	HCAG_00290	Chorismate mutase. (269 aa)
	HCAG_00648	Uncharacterized protein. (323 aa)
	HCAG_00748	Anthranilate synthase component II. (652 aa)
	HCAG_01264	Uncharacterized protein. (218 aa)
	HCAG_01497	Uncharacterized protein. (454 aa)
	HCAG_02035	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (549 aa)
	HCAG_02124	Semialdhyde_dh domain-containing protein. (338 aa)
	HCAG_02260	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
	HCAG_02357	Histidinol dehydrogenase. (1148 aa)
	HCAG_02805	Uncharacterized protein; Belongs to the TPP enzyme family. (604 aa)
	HCAG_03050	Uncharacterized protein. (344 aa)
	HCAG_03101	Aspartokinase. (518 aa)
	HCAG_03302	Uncharacterized protein. (378 aa)
	HCAG_03326	Imidazoleglycerol-phosphate dehydratase. (609 aa)
	HCAG_04000	Dihydroxy-acid dehydratase. (611 aa)
	HCAG_04242	PALP domain-containing protein. (431 aa)
	HCAG_04480	Uncharacterized protein. (307 aa)
	HCAG_04541	Uncharacterized protein. (198 aa)
	HCAG_04577	Dihydroxy-acid dehydratase. (499 aa)
	HCAG_04617	Amino transferase. (532 aa)
	HCAG_05224	Anthranilate synthase component I. (511 aa)
	HCAG_05546	Chorismate synthase. (407 aa)
	HCAG_05551	Uncharacterized protein. (651 aa)
	HCAG_05584	Mitochondrial acetolactate synthase small subunit. (336 aa)
	HCAG_06360	ATP phosphoribosyltransferase. (324 aa)
	HCAG_06421	DNA repair protein RAD16. (927 aa)
	HCAG_06729	Histidinol-phosphate aminotransferase. (321 aa)
	HCAG_05679	Aminotran_1_2 domain-containing protein. (495 aa)
	HCAG_05911	Uncharacterized protein. (281 aa)
	HCAG_05953	Tryptophan synthase. (600 aa)
	HCAG_06098	Homocitrate synthase, mitochondrial; Belongs to the alpha-IPM synthase/homocitrate synthase family. (417 aa)
	HCAG_06191	Uncharacterized protein. (388 aa)
	HCAG_07104	3-isopropylmalate dehydratase. (714 aa)
	ARG2	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family. (684 aa)
	HCAG_07563	HET domain-containing protein. (743 aa)
	HCAG_07634	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (374 aa)
	HCAG_07641	Inositol-1-monophosphatase. (333 aa)
	HCAG_07647	Uncharacterized protein. (274 aa)
	HCAG_08023	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (278 aa)
	HCAG_08076	Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (396 aa)
	HCAG_08220	Glutamine amidotransferase type-1 domain-containing protein. (834 aa)
	HCAG_08550	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa)
	HCAG_08678	Aspartate aminotransferase. (419 aa)
	HCAG_08889	PALP domain-containing protein. (411 aa)
	HCAG_08945	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (339 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG2	HCAG_00014	A6RBX7	A6QRK8	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Homoserine dehydrogenase.	0.450
ARG2	HCAG_00748	A6RBX7	A6QTP2	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Anthranilate synthase component II.	0.659
ARG2	HCAG_02035	A6RBX7	A6QXC8	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.495
ARG2	HCAG_02124	A6RBX7	A6QXL7	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Semialdhyde_dh domain-containing protein.	0.684
ARG2	HCAG_02357	A6RBX7	A6QYA0	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Histidinol dehydrogenase.	0.750
ARG2	HCAG_03101	A6RBX7	A6R0E4	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Aspartokinase.	0.441
ARG2	HCAG_05679	A6RBX7	A6R9P1	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Aminotran_1_2 domain-containing protein.	0.924
ARG2	HCAG_05953	A6RBX7	A6RAG5	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Tryptophan synthase.	0.679
ARG2	HCAG_06360	A6RBX7	A6R7R9	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	ATP phosphoribosyltransferase.	0.404
ARG2	HCAG_08678	A6RBX7	A6RGB2	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	Aspartate aminotransferase.	0.910
HCAG_00014	ARG2	A6QRK8	A6RBX7	Homoserine dehydrogenase.	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.	0.450
HCAG_00014	HCAG_00104	A6QRK8	A6QRU8	Homoserine dehydrogenase.	Acetolactate synthase.	0.488
HCAG_00014	HCAG_00290	A6QRK8	A6QSD4	Homoserine dehydrogenase.	Chorismate mutase.	0.610
HCAG_00014	HCAG_00748	A6QRK8	A6QTP2	Homoserine dehydrogenase.	Anthranilate synthase component II.	0.627
HCAG_00014	HCAG_01264	A6QRK8	A6QV57	Homoserine dehydrogenase.	Uncharacterized protein.	0.581
HCAG_00014	HCAG_01497	A6QRK8	A6QVU0	Homoserine dehydrogenase.	Uncharacterized protein.	0.633
HCAG_00014	HCAG_02035	A6QRK8	A6QXC8	Homoserine dehydrogenase.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.627
HCAG_00014	HCAG_02124	A6QRK8	A6QXL7	Homoserine dehydrogenase.	Semialdhyde_dh domain-containing protein.	0.992
HCAG_00014	HCAG_02357	A6QRK8	A6QYA0	Homoserine dehydrogenase.	Histidinol dehydrogenase.	0.812
HCAG_00014	HCAG_02805	A6QRK8	A6QZJ8	Homoserine dehydrogenase.	Uncharacterized protein; Belongs to the TPP enzyme family.	0.488