(28 nodes) Glycine, serine and threonine metabolism, and Tetrahydrofolate interconversion network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	HCAG_00081	DAO domain-containing protein. (482 aa)
	HCAG_00541	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (712 aa)
	HCAG_00793	Threonine synthase. (536 aa)
	HCAG_00881	D-amino-acid oxidase. (368 aa)
	HCAG_01437	Homoserine O-acetyltransferase. (511 aa)
	HCAG_02122	Uncharacterized protein. (276 aa)
	HCAG_02125	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (491 aa)
	HCAG_02814	Uncharacterized protein. (297 aa)
	HCAG_03111	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (488 aa)
	HCAG_03187	DAO domain-containing protein. (356 aa)
	HCAG_03455	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (143 aa)
	HCAG_04357	Formate--tetrahydrofolate ligase. (889 aa)
	HCAG_04514	Beta_elim_lyase domain-containing protein. (393 aa)
	HCAG_05244	Uncharacterized protein. (264 aa)
	HCAG_05408	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (314 aa)
	HCAG_06856	Uncharacterized protein. (434 aa)
	HCAG_06162	Aminotran_5 domain-containing protein. (327 aa)
	HCAG_06163	Uncharacterized protein. (64 aa)
	HCAG_06253	Threonine dehydratase. (540 aa)
	HCAG_06297	DAO domain-containing protein. (436 aa)
	HCAG_07043	Uncharacterized protein. (252 aa)
	HCAG_07107	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (619 aa)
	HCAG_07140	Uncharacterized protein. (262 aa)
	HCAG_07205	Beta_elim_lyase domain-containing protein. (418 aa)
	HCAG_07418	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (519 aa)
	HCAG_07571	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1122 aa)
	HCAG_08470	Threonine aldolase. (374 aa)
	HCAG_09020	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (603 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00081	HCAG_00881	A6QRS5	A6QU25	DAO domain-containing protein.	D-amino-acid oxidase.	0.915
HCAG_00081	HCAG_02125	A6QRS5	A6QXL8	DAO domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.552
HCAG_00081	HCAG_03187	A6QRS5	A6R0N0	DAO domain-containing protein.	DAO domain-containing protein.	0.915
HCAG_00081	HCAG_04514	A6QRS5	A6R4F6	DAO domain-containing protein.	Beta_elim_lyase domain-containing protein.	0.922
HCAG_00081	HCAG_05408	A6QRS5	A6R700	DAO domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.929
HCAG_00081	HCAG_06162	A6QRS5	A6RB24	DAO domain-containing protein.	Aminotran_5 domain-containing protein.	0.929
HCAG_00081	HCAG_06297	A6QRS5	A6RBF9	DAO domain-containing protein.	DAO domain-containing protein.	0.900
HCAG_00081	HCAG_07205	A6QRS5	A6RC47	DAO domain-containing protein.	Beta_elim_lyase domain-containing protein.	0.919
HCAG_00081	HCAG_07418	A6QRS5	A6RCR0	DAO domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.929
HCAG_00081	HCAG_07571	A6QRS5	A6RD63	DAO domain-containing protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.934
HCAG_00081	HCAG_08470	A6QRS5	A6RFQ4	DAO domain-containing protein.	Threonine aldolase.	0.922
HCAG_00541	HCAG_00793	A6QT35	A6QTT7	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Threonine synthase.	0.440
HCAG_00541	HCAG_02125	A6QT35	A6QXL8	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.964
HCAG_00541	HCAG_02814	A6QT35	A6QZK7	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Uncharacterized protein.	0.976
HCAG_00541	HCAG_03455	A6QT35	A6R1E8	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.775
HCAG_00541	HCAG_04357	A6QT35	A6R3Z9	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Formate--tetrahydrofolate ligase.	0.959
HCAG_00541	HCAG_04514	A6QT35	A6R4F6	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Beta_elim_lyase domain-containing protein.	0.427
HCAG_00541	HCAG_05408	A6QT35	A6R700	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.969
HCAG_00541	HCAG_07107	A6QT35	A6RBU9	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.995
HCAG_00541	HCAG_07205	A6QT35	A6RC47	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Beta_elim_lyase domain-containing protein.	0.425