(66 nodes) Mixed, incl. Hexose metabolic process, and Pentose phosphate pathway network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00010	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (273 aa)
	HCAG_00064	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Belongs to the phosphohexose mutase family. (549 aa)
	HCAG_00101	Uncharacterized protein. (527 aa)
	HCAG_00217	PLCXc domain-containing protein. (721 aa)
	HCAG_00415	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (711 aa)
	HCAG_00420	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (403 aa)
	HCAG_00638	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa)
	HCAG_00955	UDP-glucose 4-epimerase. (286 aa)
	HCAG_01222	Deoxyribose-phosphate aldolase 1. (325 aa)
	HCAG_01363	Uncharacterized protein. (302 aa)
	HCAG_01385	Uncharacterized protein. (646 aa)
	HCAG_01484	TPR_REGION domain-containing protein. (402 aa)
	HCAG_01552	Mannose-1-phosphate guanyltransferase. (364 aa)
	HCAG_01888	Uncharacterized protein. (659 aa)
	HCAG_02341	Uncharacterized protein. (234 aa)
	HCAG_02511	Triosephosphate isomerase. (91 aa)
	HCAG_03171	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (212 aa)
	HCAG_03191	Phosphotransferase. (500 aa)
	HCAG_03268	Protein kinase domain-containing protein. (1800 aa)
	HCAG_03322	Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (354 aa)
	HCAG_03385	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (418 aa)
	HCAG_03480	Glyco_transf_20 domain-containing protein. (947 aa)
	HCAG_03492	Uncharacterized protein. (338 aa)
	HCAG_03661	Phosphotransferase. (460 aa)
	HCAG_03842	Uncharacterized protein. (300 aa)
	HCAG_03884	CBM21 domain-containing protein. (557 aa)
	HCAG_03954	Fructose-2,6-bisphosphatase. (448 aa)
	HCAG_04088	Glucosamine--fructose-6-phosphate aminotransferase. (700 aa)
	HCAG_04127	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family. (361 aa)
	HCAG_04139	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (268 aa)
	HCAG_04180	Enolase_N domain-containing protein. (193 aa)
	HCAG_04329	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (503 aa)
	HCAG_04374	Uncharacterized protein. (860 aa)
	HCAG_04467	UTP--glucose-1-phosphate uridylyltransferase. (511 aa)
	HCAG_04762	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (306 aa)
	HCAG_04910	Glyceraldehyde-3-phosphate dehydrogenase. (337 aa)
	HCAG_04939	Uncharacterized protein. (292 aa)
	HCAG_05000	Transketolase 1. (650 aa)
	HCAG_05064	Uncharacterized protein. (248 aa)
	HCAG_05193	Uncharacterized protein. (325 aa)
	HCAG_05268	Trehalose-6-phosphate synthase. (518 aa)
	HCAG_05289	1,3-beta-glucan synthase component GLS1. (1901 aa)
	HCAG_05409	2,3-bisphosphoglycerate-independent phosphoglycerate mutase. (541 aa)
	HCAG_05574	Trehalase. (463 aa)
	HCAG_06406	Glyco_transf_20 domain-containing protein. (900 aa)
	HCAG_06419	Uncharacterized protein. (484 aa)
	HCAG_06614	Uncharacterized protein. (806 aa)
	HCAG_06806	Uncharacterized protein. (330 aa)
	HCAG_06881	6PF2K domain-containing protein. (543 aa)
	HCAG_06953	1,4-alpha-glucan branching enzyme. (701 aa)
	HCAG_05711	NTP_transferase domain-containing protein. (512 aa)
	HCAG_05884	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (508 aa)
	HCAG_06183	Trehalase. (658 aa)
	HCAG_06192	Uncharacterized protein. (251 aa)
	HCAG_07129	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (395 aa)
	HCAG_07552	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (794 aa)
	HCAG_08145	Phosphotransferase. (615 aa)
	HCAG_08152	Glucosamine-6-phosphate isomerase. (294 aa)
	HCAG_08159	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (367 aa)
	HCAG_08202	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	HCAG_08275	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
	HCAG_08436	Mannose-6-phosphate isomerase. (462 aa)
	HCAG_08447	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (883 aa)
	HCAG_08720	Mannitol-1-phosphate 5-dehydrogenase; Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway. (388 aa)
	HCAG_08808	Phosphoglucomutase; Belongs to the phosphohexose mutase family. (556 aa)
	HCAG_08824	Uncharacterized protein. (642 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00010	HCAG_00420	A6QRK4	A6QSR4	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	0.564
HCAG_00010	HCAG_00638	A6QRK4	A6QTD2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.968
HCAG_00010	HCAG_01222	A6QRK4	A6QV15	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Deoxyribose-phosphate aldolase 1.	0.933
HCAG_00010	HCAG_01484	A6QRK4	A6QVS7	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	TPR_REGION domain-containing protein.	0.726
HCAG_00010	HCAG_02511	A6QRK4	A6QYQ4	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Triosephosphate isomerase.	0.975
HCAG_00010	HCAG_03191	A6QRK4	A6R0N4	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Phosphotransferase.	0.890
HCAG_00010	HCAG_03322	A6QRK4	A6R115	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family.	0.980
HCAG_00010	HCAG_03385	A6QRK4	A6R178	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.992
HCAG_00010	HCAG_03492	A6QRK4	A6R1I5	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.652
HCAG_00010	HCAG_03661	A6QRK4	A6R203	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Phosphotransferase.	0.854
HCAG_00010	HCAG_04127	A6QRK4	A6R3B9	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family.	0.771
HCAG_00010	HCAG_04139	A6QRK4	A6R3D1	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.	0.655
HCAG_00010	HCAG_04180	A6QRK4	A6R3H2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Enolase_N domain-containing protein.	0.978
HCAG_00010	HCAG_04329	A6QRK4	A6R3X1	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.891
HCAG_00010	HCAG_04910	A6QRK4	A6R5K2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.994
HCAG_00010	HCAG_04939	A6QRK4	A6R5N1	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.421
HCAG_00010	HCAG_05000	A6QRK4	A6R5U2	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Transketolase 1.	0.976
HCAG_00010	HCAG_05064	A6QRK4	A6R606	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	Uncharacterized protein.	0.716
HCAG_00010	HCAG_05409	A6QRK4	A6R701	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0.876
HCAG_00010	HCAG_05884	A6QRK4	A6RA96	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	0.611