(15 nodes) Mixed, incl. Lactate metabolic process, and LACTB2, winged helix domain network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00349	D-lactate dehydrogenase 2, mitochondrial. (551 aa)
	HCAG_02530	Lactamase_B domain-containing protein. (208 aa)
	HCAG_04227	Uncharacterized protein. (1287 aa)
	HCAG_04373	FAD-binding PCMH-type domain-containing protein. (608 aa)
	HCAG_04675	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (286 aa)
	HCAG_05267	Lactamase_B domain-containing protein. (329 aa)
	HCAG_05602	Uncharacterized protein. (511 aa)
	HCAG_06845	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (385 aa)
	HCAG_07206	S-(Hydroxymethyl)glutathione dehydrogenase. (388 aa)
	HCAG_07235	FAD-binding PCMH-type domain-containing protein. (568 aa)
	HCAG_07375	Malic enzyme. (587 aa)
	HCAG_07539	Cytochrome b2, mitochondrial. (513 aa)
	HCAG_07781	Pyruvate kinase; Belongs to the pyruvate kinase family. (542 aa)
	HCAG_08012	Lactamase_B domain-containing protein. (334 aa)
	HCAG_09022	Uncharacterized protein. (343 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00349	HCAG_02530	A6QSJ3	A6QYS3	D-lactate dehydrogenase 2, mitochondrial.	Lactamase_B domain-containing protein.	0.925
HCAG_00349	HCAG_04227	A6QSJ3	A6R3L9	D-lactate dehydrogenase 2, mitochondrial.	Uncharacterized protein.	0.900
HCAG_00349	HCAG_04373	A6QSJ3	A6R415	D-lactate dehydrogenase 2, mitochondrial.	FAD-binding PCMH-type domain-containing protein.	0.916
HCAG_00349	HCAG_05602	A6QSJ3	A6R7J4	D-lactate dehydrogenase 2, mitochondrial.	Uncharacterized protein.	0.928
HCAG_00349	HCAG_07235	A6QSJ3	A6RC77	D-lactate dehydrogenase 2, mitochondrial.	FAD-binding PCMH-type domain-containing protein.	0.917
HCAG_00349	HCAG_07375	A6QSJ3	A6RCL7	D-lactate dehydrogenase 2, mitochondrial.	Malic enzyme.	0.913
HCAG_00349	HCAG_07539	A6QSJ3	A6RD31	D-lactate dehydrogenase 2, mitochondrial.	Cytochrome b2, mitochondrial.	0.937
HCAG_02530	HCAG_00349	A6QYS3	A6QSJ3	Lactamase_B domain-containing protein.	D-lactate dehydrogenase 2, mitochondrial.	0.925
HCAG_02530	HCAG_04373	A6QYS3	A6R415	Lactamase_B domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.921
HCAG_02530	HCAG_04675	A6QYS3	A6R4W7	Lactamase_B domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.527
HCAG_02530	HCAG_07235	A6QYS3	A6RC77	Lactamase_B domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.921
HCAG_02530	HCAG_09022	A6QYS3	A6RHA5	Lactamase_B domain-containing protein.	Uncharacterized protein.	0.978
HCAG_04227	HCAG_00349	A6R3L9	A6QSJ3	Uncharacterized protein.	D-lactate dehydrogenase 2, mitochondrial.	0.900
HCAG_04227	HCAG_04373	A6R3L9	A6R415	Uncharacterized protein.	FAD-binding PCMH-type domain-containing protein.	0.904
HCAG_04227	HCAG_05602	A6R3L9	A6R7J4	Uncharacterized protein.	Uncharacterized protein.	0.917
HCAG_04227	HCAG_06845	A6R3L9	A6R954	Uncharacterized protein.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.805
HCAG_04227	HCAG_07235	A6R3L9	A6RC77	Uncharacterized protein.	FAD-binding PCMH-type domain-containing protein.	0.904
HCAG_04227	HCAG_07375	A6R3L9	A6RCL7	Uncharacterized protein.	Malic enzyme.	0.978
HCAG_04227	HCAG_07539	A6R3L9	A6RD31	Uncharacterized protein.	Cytochrome b2, mitochondrial.	0.917
HCAG_04227	HCAG_07781	A6R3L9	A6RDS3	Uncharacterized protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.967