(87 nodes) Fungal-type vacuole network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_01451	Uncharacterized protein. (684 aa)
	HCAG_01334	Uncharacterized protein. (389 aa)
	HCAG_01299	Uncharacterized protein. (358 aa)
	HCAG_00065	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (328 aa)
	HCAG_00111	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (879 aa)
	HCAG_00327	E3 ubiquitin-protein ligase PEP5. (935 aa)
	HCAG_00403	Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (681 aa)
	HCAG_00404	Vacuolar ATP synthase catalytic subunit A. (636 aa)
	HCAG_00603	Uncharacterized protein; Belongs to the peptidase M18 family. (513 aa)
	LCL2	Long chronological lifespan protein 2; Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. (122 aa)
	HCAG_00620	Uncharacterized protein. (338 aa)
	HCAG_00653	Aa_trans domain-containing protein. (533 aa)
	HCAG_00654	Uncharacterized protein; Belongs to the BI1 family. (187 aa)
	HCAG_00709	Metallophos domain-containing protein. (505 aa)
	HCAG_00715	Vacuolar ATP synthase 16 kDa proteolipid subunit 2. (95 aa)
	HCAG_00795	Uncharacterized protein. (312 aa)
	HCAG_00945	Uncharacterized protein. (341 aa)
	HCAG_00946	Uncharacterized protein. (362 aa)
	HCAG_00980	Uncharacterized protein; Belongs to the alkaline phosphatase family. (637 aa)
	HCAG_01135	PKD_channel domain-containing protein. (489 aa)
	HCAG_01183	Protein rho2. (199 aa)
	HCAG_09097	Metallophos domain-containing protein. (413 aa)
	HCAG_08560	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (690 aa)
	HCAG_08212	Uncharacterized protein. (173 aa)
	HCAG_07780	PIPK domain-containing protein. (1683 aa)
	HCAG_07681	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1091 aa)
	HCAG_07432	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (361 aa)
	HCAG_07398	Uncharacterized protein. (566 aa)
	HCAG_07324	Uncharacterized protein. (407 aa)
	HCAG_07147	Purine permease. (440 aa)
	HCAG_07130	NAD_binding_2 domain-containing protein. (300 aa)
	HCAG_06034	Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (487 aa)
	HCAG_05972	PI3K/PI4K domain-containing protein. (707 aa)
	HCAG_05789	SSD domain-containing protein. (1181 aa)
	HCAG_06609	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1266 aa)
	HCAG_06571	Uncharacterized protein. (1095 aa)
	HCAG_06560	PHB domain-containing protein. (356 aa)
	HCAG_06550	Abhydrolase_2 domain-containing protein. (419 aa)
	HCAG_06506	SAC domain-containing protein. (943 aa)
	HCAG_06467	Uncharacterized protein. (335 aa)
	HCAG_05586	Uncharacterized protein. (835 aa)
	HCAG_05485	Uncharacterized protein. (157 aa)
	HCAG_05366	WD-repeat protein mip1. (1331 aa)
	HCAG_05325	Uncharacterized protein. (363 aa)
	HCAG_05261	Uncharacterized protein. (847 aa)
	HCAG_04842	Uncharacterized protein. (806 aa)
	HCAG_04780	Uncharacterized protein. (306 aa)
	HCAG_04693	Uncharacterized protein. (297 aa)
	HCAG_04627	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (663 aa)
	HCAG_04549	Alkaline phosphatase. (495 aa)
	HCAG_04379	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (420 aa)
	HCAG_04297	Uncharacterized protein; Belongs to the peptidase M18 family. (479 aa)
	HCAG_04277	Alpha-mann_mid domain-containing protein. (1088 aa)
	HCAG_04275	Uncharacterized protein. (154 aa)
	HCAG_04257	Zinc homeostasis factor 1. (525 aa)
	HCAG_04254	DUF202 domain-containing protein. (402 aa)
	HCAG_04234	Uncharacterized protein. (660 aa)
	HCAG_04157	MFS domain-containing protein. (432 aa)
	HCAG_03953	CNH domain-containing protein. (1057 aa)
	HCAG_03943	MFS domain-containing protein. (432 aa)
	HCAG_03916	MFS domain-containing protein. (437 aa)
	HCAG_03678	Vacuolar transporter chaperone 4. (836 aa)
	HCAG_03603	RING-type domain-containing protein. (562 aa)
	HCAG_03601	Uncharacterized protein. (521 aa)
	HCAG_03440	V-ATPase_H_C domain-containing protein. (552 aa)
	HCAG_03247	Uncharacterized protein. (298 aa)
	HCAG_03209	Vacuolar ATP synthase subunit E. (220 aa)
	HCAG_03166	Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
	HCAG_03162	Uncharacterized protein. (1474 aa)
	HCAG_03053	Uncharacterized protein. (595 aa)
	HCAG_02998	Protein transport protein SEC61 alpha subunit. (479 aa)
	HCAG_02868	Uncharacterized protein. (308 aa)
	HCAG_02640	Vacuolar ATP synthase subunit D. (260 aa)
	HCAG_02618	GTP-binding protein YPT7. (216 aa)
	HCAG_02560	Uncharacterized protein. (632 aa)
	HCAG_02510	Vacuolar protein 8. (662 aa)
	HCAG_02434	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (365 aa)
	HCAG_02336	CNH domain-containing protein. (722 aa)
	HCAG_02188	Uncharacterized protein. (292 aa)
	HCAG_01980	Glutaredoxin domain-containing protein. (254 aa)
	HCAG_01975	Uncharacterized protein. (208 aa)
	HCAG_01923	Uncharacterized protein. (588 aa)
	HCAG_01774	Uncharacterized protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1400 aa)
	HCAG_01600	Uncharacterized protein. (354 aa)
	HCAG_01585	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (817 aa)
	HCAG_01487	Ubiquitin conjugating enzyme MmsB. (139 aa)
	HCAG_01386	SPX domain-containing protein. (807 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00111	HCAG_02336	A6QRV5	A6QY79	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	CNH domain-containing protein.	0.400
HCAG_00111	HCAG_02618	A6QRV5	A6QZ11	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	GTP-binding protein YPT7.	0.702
HCAG_00111	HCAG_03953	A6QRV5	A6R2U5	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	CNH domain-containing protein.	0.436
HCAG_00327	HCAG_02336	A6QSH1	A6QY79	E3 ubiquitin-protein ligase PEP5.	CNH domain-containing protein.	0.995
HCAG_00327	HCAG_02618	A6QSH1	A6QZ11	E3 ubiquitin-protein ligase PEP5.	GTP-binding protein YPT7.	0.974
HCAG_00327	HCAG_03953	A6QSH1	A6R2U5	E3 ubiquitin-protein ligase PEP5.	CNH domain-containing protein.	0.995
HCAG_00327	HCAG_04627	A6QSH1	A6R4R9	E3 ubiquitin-protein ligase PEP5.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.995
HCAG_00327	HCAG_06571	A6QSH1	A6R8D0	E3 ubiquitin-protein ligase PEP5.	Uncharacterized protein.	0.995
HCAG_00403	HCAG_00404	A6QSP7	A6QSP8	Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Vacuolar ATP synthase catalytic subunit A.	0.438
HCAG_00404	HCAG_00403	A6QSP8	A6QSP7	Vacuolar ATP synthase catalytic subunit A.	Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.438
HCAG_00404	HCAG_00620	A6QSP8	A6QTB4	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.707
HCAG_00404	HCAG_00653	A6QSP8	A6QTE7	Vacuolar ATP synthase catalytic subunit A.	Aa_trans domain-containing protein.	0.549
HCAG_00404	HCAG_00715	A6QSP8	A6QTK9	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase 16 kDa proteolipid subunit 2.	0.981
HCAG_00404	HCAG_01585	A6QSP8	A6QW28	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
HCAG_00404	HCAG_02188	A6QSP8	A6QXT1	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.699
HCAG_00404	HCAG_02434	A6QSP8	A6QYH7	Vacuolar ATP synthase catalytic subunit A.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.999
HCAG_00404	HCAG_02640	A6QSP8	A6QZ33	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase subunit D.	0.999
HCAG_00404	HCAG_03162	A6QSP8	A6R0K5	Vacuolar ATP synthase catalytic subunit A.	Uncharacterized protein.	0.610
HCAG_00404	HCAG_03209	A6QSP8	A6R0Q2	Vacuolar ATP synthase catalytic subunit A.	Vacuolar ATP synthase subunit E.	0.999
HCAG_00404	HCAG_03440	A6QSP8	A6R1D3	Vacuolar ATP synthase catalytic subunit A.	V-ATPase_H_C domain-containing protein.	0.998