(21 nodes) Cellular biogenic amine metabolic process network (Histoplasma capsulatum NAm1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	HCAG_01148	Uncharacterized protein. (481 aa)
	HCAG_08550	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa)
	HCAG_08086	Uncharacterized protein. (142 aa)
	HCAG_08085	Uncharacterized protein. (264 aa)
	HCAG_07906	Glutaryl-CoA dehydrogenase, mitochondrial. (428 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	HCAG_03497	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (312 aa)
	HCAG_03352	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (315 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (192 aa)
	HCAG_01709	Uncharacterized protein. (813 aa)
	HCAG_01497	Uncharacterized protein. (454 aa)
	HCAG_00748	Anthranilate synthase component II. (652 aa)
	HCAG_00555	Uncharacterized protein. (411 aa)
	HCAG_07512	N-acetyltransferase domain-containing protein. (186 aa)
	HCAG_07293	Uncharacterized protein; Belongs to the arginase family. (179 aa)
	HCAG_07292	Uncharacterized protein; Belongs to the arginase family. (215 aa)
	HCAG_06269	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (446 aa)
	HCAG_05953	Tryptophan synthase. (600 aa)
	HCAG_05224	Anthranilate synthase component I. (511 aa)
	HCAG_04999	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (292 aa)
	HCAG_03831	Uncharacterized protein. (475 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A6QZE4	A6RDT4	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.859
BNA1	HCAG_01148	A6QZE4	A6QUU2	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.651
BNA1	HCAG_03497	A6QZE4	A6R1J0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.668
BNA1	HCAG_08085	A6QZE4	A6REM0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.980
BNA1	HCAG_08086	A6QZE4	A6REM1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.793
BNA4	BNA1	A6RDT4	A6QZE4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.859
BNA4	HCAG_01148	A6RDT4	A6QUU2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.637
BNA4	HCAG_03497	A6RDT4	A6R1J0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.572
BNA4	HCAG_08085	A6RDT4	A6REM0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.992
BNA4	HCAG_08086	A6RDT4	A6REM1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.808
HCAG_00555	HCAG_01709	A6QT49	A6QWF2	Uncharacterized protein.	Uncharacterized protein.	0.521
HCAG_00555	HCAG_04999	A6QT49	A6R5U1	Uncharacterized protein.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.986
HCAG_00555	HCAG_06269	A6QT49	A6RBD1	Uncharacterized protein.	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.661
HCAG_00748	HCAG_01497	A6QTP2	A6QVU0	Anthranilate synthase component II.	Uncharacterized protein.	0.999
HCAG_00748	HCAG_03831	A6QTP2	A6R2H3	Anthranilate synthase component II.	Uncharacterized protein.	0.454
HCAG_00748	HCAG_04999	A6QTP2	A6R5U1	Anthranilate synthase component II.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.650
HCAG_00748	HCAG_05224	A6QTP2	A6R6G6	Anthranilate synthase component II.	Anthranilate synthase component I.	0.999
HCAG_00748	HCAG_05953	A6QTP2	A6RAG5	Anthranilate synthase component II.	Tryptophan synthase.	0.999
HCAG_00748	HCAG_06269	A6QTP2	A6RBD1	Anthranilate synthase component II.	Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.714
HCAG_00748	HCAG_08085	A6QTP2	A6REM0	Anthranilate synthase component II.	Uncharacterized protein.	0.722