(95 nodes) Enzyme activator activity network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_08048	VPS9 domain-containing protein. (832 aa)
	ATG5	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] (333 aa)
	HCAG_07842	Uncharacterized protein. (631 aa)
	HCAG_07838	Uncharacterized protein. (685 aa)
	HCAG_07791	Uncharacterized protein. (336 aa)
	HCAG_07702	Uncharacterized protein. (701 aa)
	HCAG_07303	Eukaryotic translation initiation factor 5. (387 aa)
	HCAG_07833	NOT2_3_5 domain-containing protein. (449 aa)
	HCAG_07827	CUE domain-containing protein. (197 aa)
	HCAG_07824	Uncharacterized protein; Belongs to the cytochrome P450 family. (457 aa)
	HCAG_01296	Mitochondrial processing peptidase alpha subunit. (226 aa)
	HCAG_01182	Uncharacterized protein. (575 aa)
	HCAG_01064	Rab-GAP TBC domain-containing protein. (1043 aa)
	HCAG_00937	DEP domain-containing protein. (1754 aa)
	HCAG_00804	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (113 aa)
	HCAG_00777	Uncharacterized protein. (1158 aa)
	HCAG_00645	Uncharacterized protein. (296 aa)
	HCAG_00245	Uncharacterized protein. (1168 aa)
	HCAG_08186	Arf-GAP domain-containing protein. (481 aa)
	HCAG_01928	Uncharacterized protein. (183 aa)
	HCAG_01927	Uncharacterized protein. (119 aa)
	HCAG_01906	Uncharacterized protein. (464 aa)
	HCAG_01794	RPN13_C domain-containing protein. (324 aa)
	HCAG_01687	Uncharacterized protein. (95 aa)
	HCAG_01686	Uncharacterized protein. (337 aa)
	HCAG_01684	Rab-GAP TBC domain-containing protein. (888 aa)
	HCAG_01654	Uncharacterized protein. (547 aa)
	HCAG_01586	Uncharacterized protein. (1735 aa)
	HCAG_01366	CYCLIN domain-containing protein; Belongs to the cyclin family. (245 aa)
	HCAG_01295	Mitochondrial processing peptidase alpha subunit. (170 aa)
	HCAG_08773	WD_REPEATS_REGION domain-containing protein. (723 aa)
	HCAG_08717	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (414 aa)
	HCAG_08674	Uncharacterized protein. (547 aa)
	HCAG_08648	INCENP_ARK-bind domain-containing protein. (1296 aa)
	HCAG_08642	Rab-GAP TBC domain-containing protein. (755 aa)
	HCAG_08632	Neuronal calcium sensor 1. (158 aa)
	HCAG_07296	SCA7 domain-containing protein. (398 aa)
	HCAG_07204	Rho-GAP domain-containing protein. (556 aa)
	HCAG_07203	Uncharacterized protein. (82 aa)
	HCAG_07168	BRO1 domain-containing protein. (488 aa)
	HCAG_07073	RING-type domain-containing protein. (379 aa)
	HCAG_06291	Rab-GAP TBC domain-containing protein. (702 aa)
	HCAG_06154	WD-repeat protein pop3. (389 aa)
	HCAG_08473	Uncharacterized protein. (301 aa)
	HCAG_06017	Rab-GAP TBC domain-containing protein. (420 aa)
	HCAG_05904	Uncharacterized protein. (458 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). (179 aa)
	HCAG_05831	DBF4-type domain-containing protein. (611 aa)
	HCAG_05771	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (474 aa)
	HCAG_06927	Uncharacterized protein. (1018 aa)
	HCAG_06922	Integrase_H2C2 domain-containing protein. (401 aa)
	HCAG_06674	Conidiophore development protein hymA. (395 aa)
	HCAG_06673	Rab-GAP TBC domain-containing protein. (832 aa)
	HCAG_06388	Uncharacterized protein. (875 aa)
	HCAG_06365	Rho-GAP domain-containing protein. (605 aa)
	HCAG_06350	Rab-GAP TBC domain-containing protein. (764 aa)
	HCAG_05533	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa)
	HCAG_05464	Ras-GAP domain-containing protein. (424 aa)
	HCAG_05404	UDENN FLCN/SMCR8-type domain-containing protein. (425 aa)
	HCAG_05296	Ras-GAP domain-containing protein. (1390 aa)
	HCAG_05177	Uncharacterized protein. (941 aa)
	HCAG_05153	Rap-GAP domain-containing protein. (1532 aa)
	HCAG_05114	GTPase-activating protein GYP7. (792 aa)
	HCAG_05026	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (446 aa)
	HCAG_04836	Uncharacterized protein. (552 aa)
	HCAG_04835	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
	HCAG_04821	Protein phosphatases PP1 regulatory subunit sds22. (324 aa)
	HCAG_04767	Rab-GAP TBC domain-containing protein. (99 aa)
	HCAG_04494	Uncharacterized protein. (1632 aa)
	HCAG_04349	C-CAP/cofactor C-like domain-containing protein. (394 aa)
	HCAG_04295	WD_REPEATS_REGION domain-containing protein. (592 aa)
	HCAG_04276	Uncharacterized protein. (256 aa)
	HCAG_04198	Proteasome subunit beta. (203 aa)
	HCAG_04190	Proteasome component PUP3. (192 aa)
	HCAG_04097	Uncharacterized protein. (1689 aa)
	HCAG_04054	Uncharacterized protein. (1154 aa)
	HCAG_03861	Uncharacterized protein. (587 aa)
	HCAG_03814	Maintenance of ploidy protein Mob1. (218 aa)
	HCAG_03784	Uncharacterized protein. (123 aa)
	HCAG_03641	Rab-GAP TBC domain-containing protein. (618 aa)
	HCAG_03507	Uncharacterized protein. (221 aa)
	HCAG_03218	Uncharacterized protein. (608 aa)
	HCAG_03132	Arf-GAP domain-containing protein. (458 aa)
	HCAG_03018	Uncharacterized protein. (702 aa)
	HCAG_02966	Uncharacterized protein. (354 aa)
	HCAG_02915	Arf-GAP domain-containing protein. (382 aa)
	HCAG_02894	Rab-GAP TBC domain-containing protein. (892 aa)
	HCAG_02856	Uncharacterized protein. (236 aa)
	HCAG_02676	Uncharacterized protein. (410 aa)
	HCAG_02638	TFCD_C domain-containing protein. (954 aa)
	HCAG_02613	Uncharacterized protein. (765 aa)
	HCAG_02612	RanBD1 domain-containing protein. (205 aa)
	HCAG_02521	Uncharacterized protein. (570 aa)
	HCAG_02520	Nuclear protein SNF4. (379 aa)
	HCAG_02377	WD_REPEATS_REGION domain-containing protein. (616 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	A6RA46	A6RE26	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	0.999
ATG12	HCAG_03861	A6RA46	A6R2K3	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).	Uncharacterized protein.	0.507
ATG5	ATG12	A6RE26	A6RA46	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).	0.999
ATG5	HCAG_03861	A6RE26	A6R2K3	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	Uncharacterized protein.	0.462
ATG5	HCAG_05153	A6RE26	A6R695	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	Rap-GAP domain-containing protein.	0.426
HCAG_00245	HCAG_00777	A6QS89	A6QTS1	Uncharacterized protein.	Uncharacterized protein.	0.854
HCAG_00245	HCAG_01182	A6QS89	A6QUX6	Uncharacterized protein.	Uncharacterized protein.	0.755
HCAG_00245	HCAG_04097	A6QS89	A6R389	Uncharacterized protein.	Uncharacterized protein.	0.445
HCAG_00245	HCAG_06365	A6QS89	A6R7S4	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.445
HCAG_00645	HCAG_01366	A6QTD9	A6QVF9	Uncharacterized protein.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.441
HCAG_00645	HCAG_03784	A6QTD9	A6R2C6	Uncharacterized protein.	Uncharacterized protein.	0.441
HCAG_00777	HCAG_00245	A6QTS1	A6QS89	Uncharacterized protein.	Uncharacterized protein.	0.854
HCAG_00777	HCAG_01182	A6QTS1	A6QUX6	Uncharacterized protein.	Uncharacterized protein.	0.992
HCAG_00777	HCAG_02520	A6QTS1	A6QYR3	Uncharacterized protein.	Nuclear protein SNF4.	0.557
HCAG_00777	HCAG_02521	A6QTS1	A6QYR4	Uncharacterized protein.	Uncharacterized protein.	0.557
HCAG_00777	HCAG_03218	A6QTS1	A6R0R1	Uncharacterized protein.	Uncharacterized protein.	0.854
HCAG_00777	HCAG_04097	A6QTS1	A6R389	Uncharacterized protein.	Uncharacterized protein.	0.983
HCAG_00777	HCAG_04494	A6QTS1	A6R4D6	Uncharacterized protein.	Uncharacterized protein.	0.949
HCAG_00777	HCAG_04821	A6QTS1	A6R5B3	Uncharacterized protein.	Protein phosphatases PP1 regulatory subunit sds22.	0.640
HCAG_00777	HCAG_05296	A6QTS1	A6R6N8	Uncharacterized protein.	Ras-GAP domain-containing protein.	0.639