(109 nodes) Nucleotide biosynthetic process network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_01662	Uncharacterized protein. (271 aa)
	HCAG_01606	Acetyl-coenzyme A synthetase. (669 aa)
	HCAG_01433	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (478 aa)
	HCAG_01360	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (405 aa)
	HCAG_01176	Pyruvate dehydrogenase kinase. (303 aa)
	HCAG_01148	Uncharacterized protein. (481 aa)
	HCAG_01086	PAPS_reduct domain-containing protein. (416 aa)
	HCAG_01085	PAPS_reduct domain-containing protein. (230 aa)
	HCAG_00973	Mitochondrial F1F0 ATP synthase subunit F. (101 aa)
	HCAG_00966	PRK domain-containing protein. (424 aa)
	HCAG_00808	Uncharacterized protein. (290 aa)
	HCAG_00544	Nucleoside diphosphate kinase. (152 aa)
	HCAG_00538	Thymidylate_kin domain-containing protein. (232 aa)
	HCAG_00440	Phosphoribosylformylglycinamidine synthase. (1362 aa)
	HCAG_00421	Uncharacterized protein. (487 aa)
	HCAG_00404	Vacuolar ATP synthase catalytic subunit A. (636 aa)
	HCAG_00339	Uncharacterized protein. (277 aa)
	HCAG_03352	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (315 aa)
	HCAG_03497	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (312 aa)
	HCAG_03672	Flavokinase domain-containing protein. (199 aa)
	HCAG_03754	Uncharacterized protein. (1014 aa)
	HCAG_03755	Uncharacterized protein. (288 aa)
	HCAG_03809	Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (556 aa)
	HCAG_03815	ATP synthase subunit 5, mitochondrial. (226 aa)
	HCAG_03972	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (490 aa)
	HCAG_03975	Ribose-phosphate pyrophosphokinase. (90 aa)
	HCAG_03976	Ribose-phosphate pyrophosphokinase. (381 aa)
	HCAG_04136	Orotate phosphoribosyltransferase. (244 aa)
	HCAG_04224	Bifunctional purine biosynthesis protein ADE17. (626 aa)
	HCAG_04294	Peripheral subunit-binding (PSBD) domain-containing protein. (324 aa)
	HCAG_04478	Isochorismatase domain-containing protein. (256 aa)
	HCAG_04495	Inosine-5'-monophosphate dehydrogenase. (508 aa)
	HCAG_04774	Formyl_trans_N domain-containing protein. (234 aa)
	HCAG_04776	Deoxyuridine 5'-triphosphate nucleotidohydrolase. (173 aa)
	ADK2	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (275 aa)
	HCAG_04794	Uncharacterized protein; Belongs to the adenylate kinase family. (72 aa)
	HCAG_04799	ATP synthase subunit gamma. (298 aa)
	HCAG_04933	Uncharacterized protein. (486 aa)
	HCAG_05021	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (517 aa)
	HCAG_05097	Amidophosphoribosyltransferase. (604 aa)
	HCAG_05098	ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (174 aa)
	HCAG_05381	Uncharacterized protein. (61 aa)
	HCAG_05570	CTP_transf_like domain-containing protein. (296 aa)
	HCAG_05575	Uncharacterized protein. (432 aa)
	HCAG_05637	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (508 aa)
	HCAG_06410	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (276 aa)
	HCAG_06443	Uncharacterized protein. (297 aa)
	HCAG_06615	Probable acetate kinase. (428 aa)
	HCAG_06739	Uncharacterized protein. (133 aa)
	HCAG_06743	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (422 aa)
	HCAG_06816	Ribose-phosphate pyrophosphokinase I. (456 aa)
	HCAG_06908	Purine nucleoside phosphorylase. (347 aa)
	HCAG_06944	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (522 aa)
	HCAG_06963	Mitochondrial ATP synthase epsilon chain domain-containing protein. (75 aa)
	HCAG_05747	Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (313 aa)
	HCAG_05794	Uncharacterized protein. (254 aa)
	HCAG_05854	Flavoprotein domain-containing protein. (632 aa)
	HCAG_05919	RED_N domain-containing protein. (537 aa)
	HCAG_06216	Uncharacterized protein. (325 aa)
	HCAG_06311	IU_nuc_hydro domain-containing protein. (440 aa)
	HCAG_07212	Uncharacterized protein. (386 aa)
	HCAG_07264	Uncharacterized protein. (463 aa)
	HCAG_07269	DFP domain-containing protein. (409 aa)
	HCAG_07328	Isochorismatase domain-containing protein. (360 aa)
	HCAG_07330	Uncharacterized protein. (892 aa)
	HCAG_07331	Uncharacterized protein. (1003 aa)
	HCAG_07361	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (288 aa)
	HCAG_07419	Uncharacterized protein. (498 aa)
	HCAG_07619	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
	HCAG_07700	Uncharacterized protein. (173 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	HCAG_07862	Flavoprotein domain-containing protein. (223 aa)
	HCAG_07906	Glutaryl-CoA dehydrogenase, mitochondrial. (428 aa)
	HCAG_07935	Uncharacterized protein. (444 aa)
	HCAG_07999	Thymidylate synthase. (315 aa)
	HCAG_08026	Uncharacterized protein. (66 aa)
	HCAG_08078	DOMON domain-containing protein. (402 aa)
	HCAG_08085	Uncharacterized protein. (264 aa)
	HCAG_08086	Uncharacterized protein. (142 aa)
	HCAG_08357	Bifunctional pyrimidine biosynthesis protein pyrABCN. (2404 aa)
	HCAG_08512	Adenosine kinase. (374 aa)
	HCAG_08689	Phosphoribosylformylglycinamidine cyclo-ligase. (797 aa)
	HCAG_08741	Uncharacterized protein. (526 aa)
	HCAG_08801	Uncharacterized protein. (166 aa)
	ADK1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (277 aa)
	HCAG_09248	RIBORED_LARGE domain-containing protein. (524 aa)
	HCAG_03216	Amidohydro-rel domain-containing protein. (355 aa)
	HCAG_03118	Uracil phosphoribosyltransferase. (202 aa)
	HCAG_03103	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (177 aa)
	HCAG_03021	Uncharacterized protein. (53 aa)
	HCAG_03020	Uncharacterized protein. (255 aa)
	HCAG_02987	Glutamine amidotransferase type-1 domain-containing protein. (178 aa)
	HCAG_02830	Uncharacterized protein. (580 aa)
	HCAG_02828	ATP synthase subunit 4. (244 aa)
	HCAG_02813	ATP synthase alpha chain liver isoform, mitochondrial. (327 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (192 aa)
	HCAG_02727	Uncharacterized protein. (96 aa)
	HCAG_02700	Carbamoyl-phosphate synthase arginine-specific large chain. (1182 aa)
	HCAG_02604	Uncharacterized protein. (255 aa)
	HCAG_02545	Uncharacterized protein. (450 aa)
	HCAG_02255	OMPdecase domain-containing protein. (439 aa)
	HCAG_02171	Uncharacterized protein. (198 aa)
	HCAG_02160	GMP synthase subunit B. (543 aa)
	HCAG_02112	Adenine phosphoribosyltransferase 1. (214 aa)
	HCAG_02034	Uncharacterized protein. (49 aa)
	HCAG_02007	Guanylate kinase. (200 aa)
	HCAG_01878	AMP deaminase 2. (1042 aa)
	HCAG_01667	Ribose-phosphate pyrophosphokinase 3. (297 aa)
	HCAG_01663	Uncharacterized protein. (396 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK1	ADK2	A6RHI1	A6R583	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.910
ADK1	HCAG_00404	A6RHI1	A6QSP8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Vacuolar ATP synthase catalytic subunit A.	0.528
ADK1	HCAG_00421	A6RHI1	A6QSR5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Uncharacterized protein.	0.472
ADK1	HCAG_00538	A6RHI1	A6QT32	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Thymidylate_kin domain-containing protein.	0.472
ADK1	HCAG_00544	A6RHI1	A6QT38	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nucleoside diphosphate kinase.	0.961
ADK1	HCAG_00808	A6RHI1	A6QTV2	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Uncharacterized protein.	0.414
ADK1	HCAG_01433	A6RHI1	A6QVM6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.966
ADK1	HCAG_01878	A6RHI1	A6QWX1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	AMP deaminase 2.	0.936
ADK1	HCAG_02007	A6RHI1	A6QXA0	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Guanylate kinase.	0.761
ADK1	HCAG_02112	A6RHI1	A6QXK5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenine phosphoribosyltransferase 1.	0.973
ADK1	HCAG_02604	A6RHI1	A6QYZ7	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Uncharacterized protein.	0.950
ADK1	HCAG_02813	A6RHI1	A6QZK6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	ATP synthase alpha chain liver isoform, mitochondrial.	0.762
ADK1	HCAG_02987	A6RHI1	A6R030	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Glutamine amidotransferase type-1 domain-containing protein.	0.624
ADK1	HCAG_03103	A6RHI1	A6R0E6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.	0.920
ADK1	HCAG_03815	A6RHI1	A6R2F7	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	ATP synthase subunit 5, mitochondrial.	0.764
ADK1	HCAG_04224	A6RHI1	A6R3L6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Bifunctional purine biosynthesis protein ADE17.	0.542
ADK1	HCAG_04776	A6RHI1	A6R568	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Deoxyuridine 5'-triphosphate nucleotidohydrolase.	0.414
ADK1	HCAG_04799	A6RHI1	A6R591	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	ATP synthase subunit gamma.	0.784
ADK1	HCAG_05637	A6RHI1	A6R7M9	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.943
ADK1	HCAG_06410	A6RHI1	A6R7W9	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.520