(92 nodes) Lipid catabolic process network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_08974	Nonspecific lipid-transfer protein, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (458 aa)
	HCAG_08892	Uncharacterized protein. (280 aa)
	HCAG_08787	Uncharacterized protein. (163 aa)
	HCAG_08758	Uncharacterized protein. (964 aa)
	HCAG_08626	Uncharacterized protein. (633 aa)
	HCAG_08621	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	HCAG_08510	Uncharacterized protein. (444 aa)
	HCAG_08446	Uncharacterized protein. (626 aa)
	HCAG_08443	Uncharacterized protein. (265 aa)
	HCAG_08403	APH domain-containing protein. (256 aa)
	HCAG_08340	Uncharacterized protein. (170 aa)
	HCAG_08114	3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	HCAG_08058	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	ATG15	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (585 aa)
	HCAG_08039	MaoC-like domain-containing protein. (901 aa)
	HCAG_07944	Uncharacterized protein. (96 aa)
	HCAG_07925	Uncharacterized protein. (262 aa)
	HCAG_07906	Glutaryl-CoA dehydrogenase, mitochondrial. (428 aa)
	HCAG_07725	3-hydroxybutyryl-CoA dehydrogenase. (321 aa)
	HCAG_07707	Uncharacterized protein. (485 aa)
	HCAG_07696	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
	HCAG_07607	Uncharacterized protein. (895 aa)
	HCAG_07498	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. (1432 aa)
	HCAG_07450	Uncharacterized protein. (307 aa)
	HCAG_07383	Uncharacterized protein. (594 aa)
	HCAG_07368	Uncharacterized protein. (182 aa)
	HCAG_07153	Uncharacterized protein. (458 aa)
	HCAG_07123	Thiolase_N domain-containing protein. (228 aa)
	HCAG_07024	Uncharacterized protein. (61 aa)
	HCAG_06320	Phosphoinositide phospholipase C. (660 aa)
	HCAG_06256	AB hydrolase-1 domain-containing protein. (370 aa)
	HCAG_06225	Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family. (793 aa)
	HCAG_06196	Lysophospholipase. (643 aa)
	HCAG_06141	Acyl-CoA_ox_N domain-containing protein. (139 aa)
	HCAG_06125	Uncharacterized protein. (286 aa)
	HCAG_06103	Uncharacterized protein. (593 aa)
	HCAG_06005	Uncharacterized protein; Belongs to the TPP enzyme family. (590 aa)
	HCAG_05980	CoA carboxyltransferase C-terminal domain-containing protein. (399 aa)
	HCAG_05916	Endo/exonuclease/phosphatase domain-containing protein. (492 aa)
	HCAG_05815	Uncharacterized protein. (161 aa)
	HCAG_06758	Uncharacterized protein. (354 aa)
	HCAG_06491	Phospholipase. (1029 aa)
	HCAG_06346	APH domain-containing protein. (495 aa)
	HCAG_05497	Neutral ceramidase. (715 aa)
	HCAG_05359	Uncharacterized protein. (170 aa)
	HCAG_05146	Uncharacterized protein. (274 aa)
	HCAG_05123	Amidase domain-containing protein. (535 aa)
	HCAG_05090	Citrate synthase; Belongs to the citrate synthase family. (470 aa)
	HCAG_05089	Isocitrate lyase. (600 aa)
	HCAG_05084	Malate synthase; Belongs to the malate synthase family. (539 aa)
	HCAG_05020	Uncharacterized protein. (311 aa)
	HCAG_04927	Amidase domain-containing protein. (554 aa)
	HCAG_04845	PNPLA domain-containing protein. (574 aa)
	HCAG_04818	ABC transporter domain-containing protein. (675 aa)
	HCAG_04817	Uncharacterized protein; Belongs to the cytochrome P450 family. (619 aa)
	HCAG_04793	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (223 aa)
	HCAG_04480	Uncharacterized protein. (307 aa)
	HCAG_04423	Uncharacterized protein. (318 aa)
	HCAG_04378	Putative phospholipase. (523 aa)
	HCAG_04343	Negative regulator of the PHO system. (788 aa)
	HCAG_04128	Lipase_3 domain-containing protein. (491 aa)
	HCAG_03912	Lysophospholipase. (820 aa)
	HCAG_03847	Electron transfer flavoprotein subunit alpha. (348 aa)
	HCAG_03813	Uncharacterized protein. (132 aa)
	HCAG_03800	Uncharacterized protein. (820 aa)
	HCAG_03502	Phospholipase. (1251 aa)
	HCAG_03324	GP-PDE domain-containing protein. (358 aa)
	HCAG_03243	Uncharacterized protein. (501 aa)
	HCAG_03148	Uncharacterized protein. (1206 aa)
	HCAG_02967	Uncharacterized protein. (402 aa)
	HCAG_02899	APH domain-containing protein. (215 aa)
	HCAG_02897	Sporulation protein SPS19. (316 aa)
	HCAG_02812	Uncharacterized protein. (167 aa)
	HCAG_02805	Uncharacterized protein; Belongs to the TPP enzyme family. (604 aa)
	HCAG_02488	Uncharacterized protein. (471 aa)
	HCAG_02361	Nuclear elongation and deformation protein 1. (746 aa)
	HCAG_02218	Uncharacterized protein. (316 aa)
	HCAG_01982	PNPLA domain-containing protein. (617 aa)
	HCAG_01643	Uncharacterized protein. (450 aa)
	HCAG_01596	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	HCAG_01194	Uncharacterized protein. (520 aa)
	HCAG_01093	Uncharacterized protein. (296 aa)
	HCAG_01069	Uncharacterized protein. (544 aa)
	HCAG_00844	Uncharacterized protein. (507 aa)
	HCAG_00843	GP-PDE domain-containing protein. (235 aa)
	HCAG_00814	Thiolase_C domain-containing protein. (126 aa)
	HCAG_00780	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
	HCAG_00761	Uncharacterized protein. (279 aa)
	HCAG_00760	Uncharacterized protein. (243 aa)
	HCAG_00341	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa)
	HCAG_00217	PLCXc domain-containing protein. (721 aa)
	HCAG_00029	Mitochondrial methylglutaconyl-CoA hydratase. (304 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG15	HCAG_01982	A6REI4	A6QX75	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	PNPLA domain-containing protein.	0.939
ATG15	HCAG_04845	A6REI4	A6R5D7	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	PNPLA domain-containing protein.	0.493
ATG15	HCAG_06225	A6REI4	A6RB87	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family.	0.786
HCAG_00029	HCAG_00780	A6QRM3	A6QTS4	Mitochondrial methylglutaconyl-CoA hydratase.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_00814	A6QRM3	A6QTV8	Mitochondrial methylglutaconyl-CoA hydratase.	Thiolase_C domain-containing protein.	0.585
HCAG_00029	HCAG_01596	A6QRM3	A6QW39	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_03847	A6QRM3	A6R2I9	Mitochondrial methylglutaconyl-CoA hydratase.	Electron transfer flavoprotein subunit alpha.	0.458
HCAG_00029	HCAG_05146	A6QRM3	A6R688	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.500
HCAG_00029	HCAG_05980	A6QRM3	A6RAJ2	Mitochondrial methylglutaconyl-CoA hydratase.	CoA carboxyltransferase C-terminal domain-containing protein.	0.461
HCAG_00029	HCAG_06141	A6QRM3	A6RB03	Mitochondrial methylglutaconyl-CoA hydratase.	Acyl-CoA_ox_N domain-containing protein.	0.507
HCAG_00029	HCAG_07024	A6QRM3	A6RBL6	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.509
HCAG_00029	HCAG_07123	A6QRM3	A6RBW5	Mitochondrial methylglutaconyl-CoA hydratase.	Thiolase_N domain-containing protein.	0.615
HCAG_00029	HCAG_07707	A6QRM3	A6RDJ9	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.615
HCAG_00029	HCAG_07725	A6QRM3	A6RDL7	Mitochondrial methylglutaconyl-CoA hydratase.	3-hydroxybutyryl-CoA dehydrogenase.	0.957
HCAG_00029	HCAG_07906	A6QRM3	A6RE41	Mitochondrial methylglutaconyl-CoA hydratase.	Glutaryl-CoA dehydrogenase, mitochondrial.	0.494
HCAG_00029	HCAG_08114	A6QRM3	A6REP9	Mitochondrial methylglutaconyl-CoA hydratase.	3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_08621	A6QRM3	A6RG55	Mitochondrial methylglutaconyl-CoA hydratase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.585
HCAG_00029	HCAG_08626	A6QRM3	A6RG60	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.585
HCAG_00029	HCAG_08892	A6QRM3	A6RGX5	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.481
HCAG_00029	HCAG_08974	A6QRM3	A6RH57	Mitochondrial methylglutaconyl-CoA hydratase.	Nonspecific lipid-transfer protein, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	0.736