(44 nodes) Sterol biosynthetic process network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_06857	NAD_binding_1 domain-containing protein. (337 aa)
	HCAG_06888	C-5 sterol desaturase; Belongs to the sterol desaturase family. (272 aa)
	HCAG_05803	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (133 aa)
	HCAG_06013	Cytochrome P450 61; Belongs to the cytochrome P450 family. (554 aa)
	HCAG_06233	FAD-binding PCMH-type domain-containing protein. (454 aa)
	HCAG_07025	Uncharacterized protein. (193 aa)
	HCAG_07071	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (253 aa)
	HCAG_07128	Uncharacterized protein. (110 aa)
	HCAG_07564	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (380 aa)
	HCAG_07723	Uncharacterized protein. (107 aa)
	HCAG_07650	C-4 methylsterol oxidase; Belongs to the sterol desaturase family. (230 aa)
	HCAG_07922	Squalene synthetase. (493 aa)
	HCAG_08316	Uncharacterized protein. (1206 aa)
	HCAG_08321	Uncharacterized protein. (589 aa)
	HCAG_08322	AlcB domain-containing protein. (439 aa)
	HCAG_08805	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (475 aa)
	HCAG_08814	Uncharacterized protein. (310 aa)
	HCAG_00205	Uncharacterized protein. (135 aa)
	HCAG_00257	3Beta_HSD domain-containing protein. (426 aa)
	HCAG_00727	Uncharacterized protein. (255 aa)
	HCAG_00814	Thiolase_C domain-containing protein. (126 aa)
	HCAG_00949	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (428 aa)
	cprA	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (694 aa)
	HCAG_01150	Uncharacterized protein. (183 aa)
	HCAG_01378	Delta(24(24(1)))-sterol reductase. (539 aa)
	HCAG_01553	Uncharacterized protein. (449 aa)
	HCAG_01705	C-2428 sterol reductase. (475 aa)
	HCAG_01791	Uncharacterized protein. (172 aa)
	HCAG_02739	Uncharacterized protein. (417 aa)
	HCAG_02957	SE domain-containing protein. (484 aa)
	HCAG_03503	Uncharacterized protein. (455 aa)
	MCR1	NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (324 aa)
	HCAG_04488	Uncharacterized protein. (195 aa)
	HCAG_04481	Cytochrome P450 51; Belongs to the cytochrome P450 family. (522 aa)
	HCAG_04240	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (411 aa)
	HCAG_04223	Uncharacterized protein. (168 aa)
	HCAG_04048	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (525 aa)
	HCAG_06436	FAD-binding PCMH-type domain-containing protein. (685 aa)
	HCAG_05596	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (371 aa)
	HCAG_05397	PH domain-containing protein. (1298 aa)
	HCAG_05272	3Beta_HSD domain-containing protein. (456 aa)
	HCAG_04885	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (239 aa)
	HCAG_06820	EXPERA domain-containing protein. (189 aa)
	HCAG_06840	Uncharacterized protein. (229 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00205	HCAG_00257	A6QS49	A6QSA1	Uncharacterized protein.	3Beta_HSD domain-containing protein.	0.753
HCAG_00205	HCAG_01150	A6QS49	A6QUU4	Uncharacterized protein.	Uncharacterized protein.	0.891
HCAG_00205	HCAG_01378	A6QS49	A6QVH1	Uncharacterized protein.	Delta(24(24(1)))-sterol reductase.	0.754
HCAG_00205	HCAG_01553	A6QS49	A6QVZ6	Uncharacterized protein.	Uncharacterized protein.	0.888
HCAG_00205	HCAG_01705	A6QS49	A6QWE8	Uncharacterized protein.	C-2428 sterol reductase.	0.754
HCAG_00205	HCAG_01791	A6QS49	A6QWN4	Uncharacterized protein.	Uncharacterized protein.	0.558
HCAG_00205	HCAG_02957	A6QS49	A6R000	Uncharacterized protein.	SE domain-containing protein.	0.905
HCAG_00205	HCAG_04048	A6QS49	A6R340	Uncharacterized protein.	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family.	0.840
HCAG_00205	HCAG_04240	A6QS49	A6R3N2	Uncharacterized protein.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.411
HCAG_00205	HCAG_04481	A6QS49	A6R4C3	Uncharacterized protein.	Cytochrome P450 51; Belongs to the cytochrome P450 family.	0.840
HCAG_00205	HCAG_04488	A6QS49	A6R4D0	Uncharacterized protein.	Uncharacterized protein.	0.412
HCAG_00205	HCAG_04885	A6QS49	A6R5H7	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.497
HCAG_00205	HCAG_05272	A6QS49	A6R6L4	Uncharacterized protein.	3Beta_HSD domain-containing protein.	0.753
HCAG_00205	HCAG_05596	A6QS49	A6R7I8	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.422
HCAG_00205	HCAG_06013	A6QS49	A6RAM5	Uncharacterized protein.	Cytochrome P450 61; Belongs to the cytochrome P450 family.	0.648
HCAG_00205	HCAG_06888	A6QS49	A6R997	Uncharacterized protein.	C-5 sterol desaturase; Belongs to the sterol desaturase family.	0.930
HCAG_00205	HCAG_07071	A6QS49	A6RBR3	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.558
HCAG_00205	HCAG_07128	A6QS49	A6RBX0	Uncharacterized protein.	Uncharacterized protein.	0.870
HCAG_00205	HCAG_07564	A6QS49	A6RD56	Uncharacterized protein.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.888
HCAG_00205	HCAG_07650	A6QS49	A6RDE2	Uncharacterized protein.	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.654