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CIA1 CIA1 DRE2 DRE2 HCAG_01677 HCAG_01677 HCAG_01676 HCAG_01676 HCAG_01495 HCAG_01495 HCAG_01208 HCAG_01208 HCAG_01147 HCAG_01147 NBP35 NBP35 HCAG_00812 HCAG_00812 HCAG_00572 HCAG_00572 HCAG_00552 HCAG_00552 HCAG_05510 HCAG_05510 HCAG_05782 HCAG_05782 HCAG_06107 HCAG_06107 HCAG_08081 HCAG_08081 HCAG_09185 HCAG_09185 HCAG_02578 HCAG_02578 HCAG_02735 HCAG_02735 HCAG_02818 HCAG_02818 HCAG_02819 HCAG_02819 HCAG_02930 HCAG_02930 HCAG_03616 HCAG_03616
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CIA1Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (491 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (351 aa)
HCAG_01677Iron-binding protein iscA. (285 aa)
HCAG_01676Uncharacterized protein. (393 aa)
HCAG_01495Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (630 aa)
HCAG_01208Uncharacterized protein. (601 aa)
HCAG_01147Cysteine desulfurase, mitochondrial. (986 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa)
HCAG_00812FeS_assembly_P domain-containing protein. (235 aa)
HCAG_005722Fe-2S ferredoxin-type domain-containing protein. (165 aa)
HCAG_00552Uncharacterized protein. (328 aa)
HCAG_05510Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (141 aa)
HCAG_05782Uncharacterized protein. (341 aa)
HCAG_06107Uncharacterized protein. (228 aa)
HCAG_08081Fe-S_biosyn domain-containing protein. (230 aa)
HCAG_09185Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (203 aa)
HCAG_02578Uncharacterized protein. (162 aa)
HCAG_02735J domain-containing protein. (279 aa)
HCAG_02818Uncharacterized protein. (652 aa)
HCAG_02819MMS19_C domain-containing protein. (174 aa)
HCAG_02930FAD-binding FR-type domain-containing protein. (422 aa)
HCAG_03616Nfu_N domain-containing protein. (279 aa)
Your Current Organism:
Histoplasma capsulatum NAm1
NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1
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