(89 nodes) Heme binding network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_02256	Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily. (385 aa)
	HCAG_00301	Uncharacterized protein. (172 aa)
	HCAG_00352	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	HCAG_00428	Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
	HCAG_00631	Uncharacterized protein. (756 aa)
	HCAG_00651	Uncharacterized protein. (487 aa)
	HCAG_00765	Nitrate reductase. (382 aa)
	HCAG_01032	Uncharacterized protein. (173 aa)
	HCAG_01033	POR_N domain-containing protein. (506 aa)
	HCAG_01100	Uncharacterized protein. (1324 aa)
	HCAG_01148	Uncharacterized protein. (481 aa)
	HCAG_01369	Uncharacterized protein. (928 aa)
	HCAG_01393	Uncharacterized protein; Belongs to the cytochrome P450 family. (434 aa)
	HCAG_01435	Uncharacterized protein. (675 aa)
	HCAG_01669	Uncharacterized protein. (1030 aa)
	HCAG_01674	Uncharacterized protein. (449 aa)
	HCAG_01834	HpcH_HpaI domain-containing protein. (189 aa)
	HCAG_01841	Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
	HCAG_01856	Uncharacterized protein. (192 aa)
	HCAG_01861	Uncharacterized protein. (374 aa)
	HCAG_01944	Uncharacterized protein; Belongs to the cytochrome P450 family. (518 aa)
	HCAG_02040	Uncharacterized protein. (283 aa)
	HCAG_02187	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (294 aa)
	HCAG_02289	VWFA domain-containing protein. (279 aa)
	HCAG_02344	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (203 aa)
	HCAG_02450	Uncharacterized protein. (343 aa)
	HCAG_02767	Uncharacterized protein. (166 aa)
	HCAG_02768	Uncharacterized protein. (279 aa)
	HCAG_02769	Uncharacterized protein. (398 aa)
	HCAG_02771	Uncharacterized protein. (454 aa)
	HCAG_02826	Uncharacterized protein. (318 aa)
	HCAG_03010	Uncharacterized protein; Belongs to the cytochrome P450 family. (520 aa)
	HCAG_03184	Uncharacterized protein; Belongs to the cytochrome P450 family. (471 aa)
	HCAG_03273	Cytochrome c1. (326 aa)
	HCAG_03309	Uncharacterized protein; Belongs to the cytochrome P450 family. (440 aa)
	HCAG_03839	Uncharacterized protein; Belongs to the cytochrome P450 family. (548 aa)
	HCAG_03844	Uncharacterized protein. (126 aa)
	HCAG_03845	Uncharacterized protein. (440 aa)
	HCAG_03929	Uncharacterized protein. (249 aa)
	HCAG_03942	Zn(2)-C6 fungal-type domain-containing protein. (758 aa)
	HCAG_03961	FAD-binding PCMH-type domain-containing protein. (497 aa)
	HCAG_03984	Uncharacterized protein. (536 aa)
	HCAG_04048	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (525 aa)
	HCAG_04237	Uncharacterized protein. (97 aa)
	HCAG_04481	Cytochrome P450 51; Belongs to the cytochrome P450 family. (522 aa)
	HCAG_04596	Uncharacterized protein; Belongs to the cytochrome P450 family. (655 aa)
	HCAG_04817	Uncharacterized protein; Belongs to the cytochrome P450 family. (619 aa)
	HCAG_04831	Uncharacterized protein. (291 aa)
	HCAG_05109	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (749 aa)
	HCAG_05157	Uncharacterized protein. (248 aa)
	HCAG_05158	Uncharacterized protein; Belongs to the cytochrome P450 family. (194 aa)
	HCAG_05292	Uncharacterized protein. (513 aa)
	HCAG_05359	Uncharacterized protein. (170 aa)
	HCAG_05588	Uncharacterized protein. (281 aa)
	HCAG_05628	Uncharacterized protein. (175 aa)
	HCAG_06390	Uncharacterized protein. (504 aa)
	HCAG_06394	Uncharacterized protein. (283 aa)
	HCAG_06395	Uncharacterized protein. (82 aa)
	HCAG_06579	Uncharacterized protein. (358 aa)
	HCAG_06937	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	HCAG_05706	FAD-binding FR-type domain-containing protein. (603 aa)
	HCAG_05803	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (133 aa)
	HCAG_05927	Uncharacterized protein. (201 aa)
	HCAG_05938	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
	HCAG_06013	Cytochrome P450 61; Belongs to the cytochrome P450 family. (554 aa)
	HCAG_06254	Uncharacterized protein. (745 aa)
	HCAG_06330	Uncharacterized protein. (635 aa)
	HCAG_07098	Peroxidase; Belongs to the peroxidase family. (224 aa)
	HCAG_07148	Uncharacterized protein. (129 aa)
	HCAG_07149	Uncharacterized protein; Belongs to the cytochrome P450 family. (526 aa)
	HCAG_07200	Uncharacterized protein. (1049 aa)
	HCAG_07266	Uncharacterized protein. (507 aa)
	HCAG_07291	Uncharacterized protein; Belongs to the cytochrome P450 family. (350 aa)
	HCAG_07450	Uncharacterized protein. (307 aa)
	HCAG_07539	Cytochrome b2, mitochondrial. (513 aa)
	HCAG_07578	Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (728 aa)
	HCAG_07971	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (177 aa)
	HCAG_07981	F-box domain-containing protein. (714 aa)
	HCAG_08064	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (503 aa)
	HCAG_08121	Uncharacterized protein. (455 aa)
	HCAG_08154	Uncharacterized protein. (481 aa)
	HCAG_08280	Methyltransf_11 domain-containing protein. (943 aa)
	HCAG_08565	Uncharacterized protein; Belongs to the cytochrome P450 family. (407 aa)
	HCAG_08657	Uncharacterized protein. (144 aa)
	HCAG_08658	Peroxidase; Belongs to the peroxidase family. (303 aa)
	HCAG_08852	F-box domain-containing protein. (276 aa)
	HCAG_09082	Uncharacterized protein. (70 aa)
	HCAG_09289	Flavodoxin-like domain-containing protein. (448 aa)
	HCAG_09319	Peroxidase; Belongs to the peroxidase family. (125 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00352	HCAG_01944	A6QSJ6	A6QX37	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.449
HCAG_00352	HCAG_02040	A6QSJ6	A6QXD3	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.486
HCAG_00352	HCAG_03839	A6QSJ6	A6R2I1	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.512
HCAG_00352	HCAG_05927	A6QSJ6	A6RAD9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.473
HCAG_00352	HCAG_06937	A6QSJ6	A6R9E6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.401
HCAG_00352	HCAG_07291	A6QSJ6	A6RCD3	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.440
HCAG_00352	HCAG_08121	A6QSJ6	A6REQ6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.522
HCAG_00428	HCAG_05927	A6QSS2	A6RAD9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.435
HCAG_00428	HCAG_08121	A6QSS2	A6REQ6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.444
HCAG_00765	HCAG_01032	A6QTQ9	A6QUH6	Nitrate reductase.	Uncharacterized protein.	0.864
HCAG_00765	HCAG_01033	A6QTQ9	A6QUH7	Nitrate reductase.	POR_N domain-containing protein.	0.864
HCAG_00765	HCAG_01435	A6QTQ9	A6QVM8	Nitrate reductase.	Uncharacterized protein.	0.839
HCAG_00765	HCAG_02256	A6QTQ9	A6QXZ9	Nitrate reductase.	Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.	0.743
HCAG_00765	HCAG_03273	A6QTQ9	A6R0W6	Nitrate reductase.	Cytochrome c1.	0.649
HCAG_00765	HCAG_05706	A6QTQ9	A6R9R8	Nitrate reductase.	FAD-binding FR-type domain-containing protein.	0.719
HCAG_00765	HCAG_05803	A6QTQ9	A6RA15	Nitrate reductase.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.435
HCAG_00765	HCAG_05938	A6QTQ9	A6RAF0	Nitrate reductase.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.839
HCAG_00765	HCAG_06254	A6QTQ9	A6RBB6	Nitrate reductase.	Uncharacterized protein.	0.719
HCAG_00765	HCAG_07200	A6QTQ9	A6RC42	Nitrate reductase.	Uncharacterized protein.	0.912
HCAG_00765	HCAG_07539	A6QTQ9	A6RD31	Nitrate reductase.	Cytochrome b2, mitochondrial.	0.684