(56 nodes) Cortical cytoskeleton network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_08090	SH3 domain-containing protein. (1196 aa)
	HCAG_00532	TGc domain-containing protein. (981 aa)
	HCAG_00701	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2501 aa)
	HCAG_00741	Uncharacterized protein. (582 aa)
	HCAG_00771	Adenylyl cyclase-associated protein; Belongs to the CAP family. (500 aa)
	HCAG_00809	Fungal_trans domain-containing protein. (557 aa)
	HCAG_00848	Arp2/3 complex subunit; Belongs to the actin family. (439 aa)
	HCAG_00890	ADF-H domain-containing protein. (147 aa)
	HCAG_01146	Uncharacterized protein. (412 aa)
	HCAG_01158	Protein kinase domain-containing protein. (271 aa)
	HCAG_01167	I/LWEQ domain-containing protein. (1031 aa)
	HCAG_01182	Uncharacterized protein. (575 aa)
	HCAG_01852	WH2 domain-containing protein. (477 aa)
	HCAG_01880	Uncharacterized protein. (790 aa)
	HCAG_02067	Uncharacterized protein. (1278 aa)
	HCAG_02644	DH domain-containing protein. (1336 aa)
	HCAG_02733	Uncharacterized protein. (689 aa)
	HCAG_03028	CRIB domain-containing protein. (698 aa)
	HCAG_03174	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (174 aa)
	HCAG_03175	Uncharacterized protein. (790 aa)
	HCAG_03222	Uncharacterized protein. (765 aa)
	HCAG_03646	WD_REPEATS_REGION domain-containing protein. (622 aa)
	HCAG_04014	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (801 aa)
	HCAG_04015	Coronin; Belongs to the WD repeat coronin family. (485 aa)
	HCAG_04083	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1035 aa)
	HCAG_04115	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (369 aa)
	HCAG_04225	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1631 aa)
	HCAG_04486	Uncharacterized protein. (235 aa)
	HCAG_04487	Uncharacterized protein. (419 aa)
	HCAG_04752	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (266 aa)
	HCAG_04901	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
	HCAG_04983	TYR_PHOSPHATASE_2 domain-containing protein. (616 aa)
	HCAG_05293	DUF2013 domain-containing protein. (749 aa)
	HCAG_06375	Uncharacterized protein. (161 aa)
	PAN1	Actin cytoskeleton-regulatory complex protein PAN1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1481 aa)
	HCAG_05731	VHS domain-containing protein. (404 aa)
	HCAG_05796	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (267 aa)
	HCAG_05797	Uncharacterized protein. (494 aa)
	HCAG_05911	Uncharacterized protein. (281 aa)
	HCAG_06135	Uncharacterized protein. (799 aa)
	HCAG_06157	Uncharacterized protein. (358 aa)
	HCAG_06164	Uncharacterized protein. (166 aa)
	HCAG_06165	Myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (759 aa)
	HCAG_07039	Calponin-homology (CH) domain-containing protein. (393 aa)
	HCAG_07144	Myosin regulatory light chain cdc4. (157 aa)
	HCAG_07209	Uncharacterized protein. (758 aa)
	HCAG_07461	Uncharacterized protein. (623 aa)
	HCAG_07842	Uncharacterized protein. (631 aa)
	HCAG_08430	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	END3	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (405 aa)
	HCAG_08462	Uncharacterized protein. (844 aa)
	HCAG_08863	C2 domain-containing protein. (1009 aa)
	HCAG_09029	SH3 domain-containing protein. (409 aa)
	HCAG_00095	F-BAR domain-containing protein. (932 aa)
	HCAG_00344	IPPc domain-containing protein. (1181 aa)
	HCAG_00403	Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (681 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
END3	HCAG_00095	A6RFP4	A6QRT9	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	F-BAR domain-containing protein.	0.578
END3	HCAG_01167	A6RFP4	A6QUW1	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	I/LWEQ domain-containing protein.	0.543
END3	HCAG_02067	A6RFP4	A6QXG0	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.665
END3	HCAG_02733	A6RFP4	A6QZC6	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.596
END3	HCAG_03222	A6RFP4	A6R0R5	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.643
END3	HCAG_04225	A6RFP4	A6R3L7	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.651
HCAG_00095	END3	A6QRT9	A6RFP4	F-BAR domain-containing protein.	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	0.578
HCAG_00095	HCAG_00532	A6QRT9	A6QT26	F-BAR domain-containing protein.	TGc domain-containing protein.	0.891
HCAG_00095	HCAG_00701	A6QRT9	A6QTJ5	F-BAR domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.889
HCAG_00095	HCAG_00848	A6QRT9	A6QTZ2	F-BAR domain-containing protein.	Arp2/3 complex subunit; Belongs to the actin family.	0.606
HCAG_00095	HCAG_01146	A6QRT9	A6QUU0	F-BAR domain-containing protein.	Uncharacterized protein.	0.751
HCAG_00095	HCAG_01167	A6QRT9	A6QUW1	F-BAR domain-containing protein.	I/LWEQ domain-containing protein.	0.598
HCAG_00095	HCAG_01182	A6QRT9	A6QUX6	F-BAR domain-containing protein.	Uncharacterized protein.	0.724
HCAG_00095	HCAG_01852	A6QRT9	A6QWU5	F-BAR domain-containing protein.	WH2 domain-containing protein.	0.520
HCAG_00095	HCAG_02067	A6QRT9	A6QXG0	F-BAR domain-containing protein.	Uncharacterized protein.	0.578
HCAG_00095	HCAG_03222	A6QRT9	A6R0R5	F-BAR domain-containing protein.	Uncharacterized protein.	0.842
HCAG_00095	HCAG_04115	A6QRT9	A6R3A7	F-BAR domain-containing protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family.	0.546
HCAG_00095	HCAG_04225	A6QRT9	A6R3L7	F-BAR domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.848
HCAG_00095	HCAG_04983	A6QRT9	A6R5S5	F-BAR domain-containing protein.	TYR_PHOSPHATASE_2 domain-containing protein.	0.621
HCAG_00095	HCAG_06135	A6QRT9	A6RAZ7	F-BAR domain-containing protein.	Uncharacterized protein.	0.836