(37 nodes) Cortical cytoskeleton organization network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_07506	Profilin; Belongs to the profilin family. (148 aa)
	HCAG_02615	Uncharacterized protein. (417 aa)
	HCAG_04225	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1631 aa)
	HCAG_04706	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (318 aa)
	HCAG_04752	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (266 aa)
	HCAG_04901	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
	HCAG_04983	TYR_PHOSPHATASE_2 domain-containing protein. (616 aa)
	HCAG_05293	DUF2013 domain-containing protein. (749 aa)
	HCAG_05384	Uncharacterized protein. (253 aa)
	HCAG_05560	Uncharacterized protein. (192 aa)
	HCAG_06375	Uncharacterized protein. (161 aa)
	HCAG_00741	Uncharacterized protein. (582 aa)
	HCAG_00848	Arp2/3 complex subunit; Belongs to the actin family. (439 aa)
	HCAG_01053	Uncharacterized protein. (187 aa)
	HCAG_01146	Uncharacterized protein. (412 aa)
	HCAG_01241	Protein Rho3. (206 aa)
	HCAG_02424	DUF4045 domain-containing protein. (911 aa)
	HCAG_08210	Actin. (375 aa)
	HCAG_08430	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	HCAG_08008	Chitin synthase 2. (1277 aa)
	HCAG_00095	F-BAR domain-containing protein. (932 aa)
	HCAG_00107	Uncharacterized protein. (197 aa)
	HCAG_06610	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (193 aa)
	HCAG_06686	MHD domain-containing protein. (858 aa)
	HCAG_06848	Cytokinesis protein sepA. (1670 aa)
	HCAG_06135	Uncharacterized protein. (799 aa)
	HCAG_00171	Protein kinase domain-containing protein. (821 aa)
	HCAG_06164	Uncharacterized protein. (166 aa)
	HCAG_06165	Myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (759 aa)
	HCAG_07144	Myosin regulatory light chain cdc4. (157 aa)
	HCAG_00701	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2501 aa)
	HCAG_01167	I/LWEQ domain-containing protein. (1031 aa)
	HCAG_02733	Uncharacterized protein. (689 aa)
	HCAG_03028	CRIB domain-containing protein. (698 aa)
	HCAG_03174	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (174 aa)
	HCAG_03175	Uncharacterized protein. (790 aa)
	HCAG_04115	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (369 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00095	HCAG_00171	A6QRT9	A6QS15	F-BAR domain-containing protein.	Protein kinase domain-containing protein.	0.600
HCAG_00095	HCAG_00701	A6QRT9	A6QTJ5	F-BAR domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.889
HCAG_00095	HCAG_00848	A6QRT9	A6QTZ2	F-BAR domain-containing protein.	Arp2/3 complex subunit; Belongs to the actin family.	0.606
HCAG_00095	HCAG_01146	A6QRT9	A6QUU0	F-BAR domain-containing protein.	Uncharacterized protein.	0.751
HCAG_00095	HCAG_01167	A6QRT9	A6QUW1	F-BAR domain-containing protein.	I/LWEQ domain-containing protein.	0.598
HCAG_00095	HCAG_02424	A6QRT9	A6QYG7	F-BAR domain-containing protein.	DUF4045 domain-containing protein.	0.629
HCAG_00095	HCAG_04115	A6QRT9	A6R3A7	F-BAR domain-containing protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family.	0.546
HCAG_00095	HCAG_04225	A6QRT9	A6R3L7	F-BAR domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.848
HCAG_00095	HCAG_04983	A6QRT9	A6R5S5	F-BAR domain-containing protein.	TYR_PHOSPHATASE_2 domain-containing protein.	0.621
HCAG_00095	HCAG_06135	A6QRT9	A6RAZ7	F-BAR domain-containing protein.	Uncharacterized protein.	0.836
HCAG_00095	HCAG_06164	A6QRT9	A6RB26	F-BAR domain-containing protein.	Uncharacterized protein.	0.442
HCAG_00095	HCAG_06165	A6QRT9	A6RB27	F-BAR domain-containing protein.	Myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.442
HCAG_00095	HCAG_06610	A6QRT9	A6R8G9	F-BAR domain-containing protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.590
HCAG_00095	HCAG_06848	A6QRT9	A6R957	F-BAR domain-containing protein.	Cytokinesis protein sepA.	0.880
HCAG_00095	HCAG_07144	A6QRT9	A6RBY6	F-BAR domain-containing protein.	Myosin regulatory light chain cdc4.	0.623
HCAG_00095	HCAG_08008	A6QRT9	A6REE3	F-BAR domain-containing protein.	Chitin synthase 2.	0.582
HCAG_00095	HCAG_08210	A6QRT9	A6REZ5	F-BAR domain-containing protein.	Actin.	0.634
HCAG_00095	HCAG_08430	A6QRT9	A6RFL4	F-BAR domain-containing protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.622
HCAG_00107	HCAG_00701	A6QRV1	A6QTJ5	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.453
HCAG_00107	HCAG_00741	A6QRV1	A6QTN5	Uncharacterized protein.	Uncharacterized protein.	0.411