STRINGSTRING
PRM1 PRM1 HCAG_01501 HCAG_01501 HCAG_01271 HCAG_01271 FEN1 FEN1 HCAG_01087 HCAG_01087 HCAG_00807 HCAG_00807 HCAG_00166 HCAG_00166 HCAG_09223 HCAG_09223 HCAG_09016 HCAG_09016 HCAG_08430 HCAG_08430 HCAG_08288 HCAG_08288 HCAG_08111 HCAG_08111 HCAG_07553 HCAG_07553 HCAG_06302 HCAG_06302 HCAG_06143 HCAG_06143 HCAG_05911 HCAG_05911 HCAG_06674 HCAG_06674 HCAG_06491 HCAG_06491 HCAG_06474 HCAG_06474 HCAG_05469 HCAG_05469 HCAG_05465 HCAG_05465 HCAG_05369 HCAG_05369 HCAG_05268 HCAG_05268 HCAG_05077 HCAG_05077 HCAG_04841 HCAG_04841 HCAG_04636 HCAG_04636 HCAG_04331 HCAG_04331 HCAG_03502 HCAG_03502 uba4 uba4 HCAG_03019 HCAG_03019 HCAG_02857 HCAG_02857
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRM1Plasma membrane fusion protein PRM1; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event; Belongs to the PRM1 family. (736 aa)
HCAG_01501Serine/threonine-protein kinase cot-1. (639 aa)
HCAG_01271PIPK domain-containing protein. (781 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
HCAG_01087RRM domain-containing protein. (314 aa)
HCAG_00807Serine/threonine-protein phosphatase. (213 aa)
HCAG_00166F-box domain-containing protein. (551 aa)
HCAG_09223RRM domain-containing protein. (466 aa)
HCAG_09016Non-specific serine/threonine protein kinase. (904 aa)
HCAG_08430Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
HCAG_08288Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
HCAG_08111Rtf2 domain-containing protein. (322 aa)
HCAG_07553Mannan endo-1,6-alpha-mannosidase. (448 aa)
HCAG_06302Uncharacterized protein. (161 aa)
HCAG_06143AIP3 domain-containing protein. (1021 aa)
HCAG_05911Uncharacterized protein. (281 aa)
HCAG_06674Conidiophore development protein hymA. (395 aa)
HCAG_06491Phospholipase. (1029 aa)
HCAG_06474Uncharacterized protein. (1891 aa)
HCAG_05469KH_dom_type_1 domain-containing protein. (769 aa)
HCAG_05465CRAL-TRIO domain-containing protein. (306 aa)
HCAG_05369Uncharacterized protein. (142 aa)
HCAG_05268Trehalose-6-phosphate synthase. (518 aa)
HCAG_05077Uncharacterized protein. (387 aa)
HCAG_04841Serine/threonine-protein phosphatase. (253 aa)
HCAG_04636Uncharacterized protein. (325 aa)
HCAG_04331Uncharacterized protein. (332 aa)
HCAG_03502Phospholipase. (1251 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (530 aa)
HCAG_03019Non-specific serine/threonine protein kinase. (881 aa)
HCAG_02857Chitin synthase D. (1220 aa)
Your Current Organism:
Histoplasma capsulatum NAm1
NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1
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