(23 nodes) Ribosome binding network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00129	Uncharacterized protein. (380 aa)
	HCAG_04288	Letm1 RBD domain-containing protein. (538 aa)
	HCAG_03553	Uncharacterized protein. (304 aa)
	HCAG_03280	Integrase catalytic domain-containing protein. (2373 aa)
	HCAG_02998	Protein transport protein SEC61 alpha subunit. (479 aa)
	HCAG_02945	Uncharacterized protein. (97 aa)
	HCAG_02508	Tr-type G domain-containing protein. (968 aa)
	HCAG_02237	Uncharacterized protein. (942 aa)
	HCAG_07439	Uncharacterized protein. (283 aa)
	HCAG_07567	J domain-containing protein. (445 aa)
	GUF1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (657 aa)
	HCAG_09188	MIT domain-containing protein. (390 aa)
	HCAG_05779	Uncharacterized protein. (251 aa)
	HCAG_06747	OBG-type G domain-containing protein. (637 aa)
	HCAG_06676	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
	HCAG_01253	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (687 aa)
	HCAG_01136	Eukaryotic translation initiation factor 2 alpha subunit. (309 aa)
	HCAG_05402	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (253 aa)
	HCAG_00683	Woronin body major protein. (311 aa)
	HCAG_06021	Eukaryotic translation initiation factor 5A. (161 aa)
	HCAG_05988	Tr-type G domain-containing protein. (631 aa)
	HCAG_07408	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (1925 aa)
	HCAG_07031	WD_REPEATS_REGION domain-containing protein. (316 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GUF1	HCAG_09188	A6RGX9	A6RHR0	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.	MIT domain-containing protein.	0.760
HCAG_00683	HCAG_01136	A6QTH7	A6QUT0	Woronin body major protein.	Eukaryotic translation initiation factor 2 alpha subunit.	0.487
HCAG_00683	HCAG_02237	A6QTH7	A6QXY0	Woronin body major protein.	Uncharacterized protein.	0.865
HCAG_00683	HCAG_02508	A6QTH7	A6QYQ1	Woronin body major protein.	Tr-type G domain-containing protein.	0.713
HCAG_00683	HCAG_02945	A6QTH7	A6QZY8	Woronin body major protein.	Uncharacterized protein.	0.674
HCAG_00683	HCAG_05988	A6QTH7	A6RAK0	Woronin body major protein.	Tr-type G domain-containing protein.	0.816
HCAG_00683	HCAG_07031	A6QTH7	A6RBM3	Woronin body major protein.	WD_REPEATS_REGION domain-containing protein.	0.865
HCAG_01136	HCAG_00683	A6QUT0	A6QTH7	Eukaryotic translation initiation factor 2 alpha subunit.	Woronin body major protein.	0.487
HCAG_01136	HCAG_01253	A6QUT0	A6QV46	Eukaryotic translation initiation factor 2 alpha subunit.	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	0.503
HCAG_01136	HCAG_02237	A6QUT0	A6QXY0	Eukaryotic translation initiation factor 2 alpha subunit.	Uncharacterized protein.	0.834
HCAG_01136	HCAG_02508	A6QUT0	A6QYQ1	Eukaryotic translation initiation factor 2 alpha subunit.	Tr-type G domain-containing protein.	0.428
HCAG_01136	HCAG_02945	A6QUT0	A6QZY8	Eukaryotic translation initiation factor 2 alpha subunit.	Uncharacterized protein.	0.531
HCAG_01136	HCAG_05402	A6QUT0	A6R6Z4	Eukaryotic translation initiation factor 2 alpha subunit.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.972
HCAG_01136	HCAG_05988	A6QUT0	A6RAK0	Eukaryotic translation initiation factor 2 alpha subunit.	Tr-type G domain-containing protein.	0.620
HCAG_01136	HCAG_06021	A6QUT0	A6RAN3	Eukaryotic translation initiation factor 2 alpha subunit.	Eukaryotic translation initiation factor 5A.	0.487
HCAG_01136	HCAG_06676	A6QUT0	A6R8N5	Eukaryotic translation initiation factor 2 alpha subunit.	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.433
HCAG_01136	HCAG_07031	A6QUT0	A6RBM3	Eukaryotic translation initiation factor 2 alpha subunit.	WD_REPEATS_REGION domain-containing protein.	0.915
HCAG_01136	HCAG_07408	A6QUT0	A6RCQ0	Eukaryotic translation initiation factor 2 alpha subunit.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.733
HCAG_01136	HCAG_07567	A6QUT0	A6RD59	Eukaryotic translation initiation factor 2 alpha subunit.	J domain-containing protein.	0.530
HCAG_01253	HCAG_01136	A6QV46	A6QUT0	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 alpha subunit.	0.503