(16 nodes) Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00967	Uncharacterized protein. (259 aa)
	HCAG_01151	Uncharacterized protein. (599 aa)
	HCAG_01966	Uncharacterized protein. (211 aa)
	HCAG_02174	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (238 aa)
	HCAG_06132	Uncharacterized protein. (236 aa)
	HCAG_06159	E3 ubiquitin-protein ligase. (883 aa)
	HCAG_02484	Uncharacterized protein. (228 aa)
	HCAG_03454	Uncharacterized protein. (532 aa)
	HCAG_08016	GLUE N-terminal domain-containing protein. (646 aa)
	HCAG_08344	Uncharacterized protein. (227 aa)
	HCAG_08804	Uncharacterized protein. (892 aa)
	HCAG_04350	MPN domain-containing protein. (519 aa)
	HCAG_05310	USP domain-containing protein; Belongs to the peptidase C19 family. (1300 aa)
	HCAG_05491	Uncharacterized protein. (223 aa)
	HCAG_08705	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (266 aa)
	HCAG_05521	Uncharacterized protein. (646 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_01151	HCAG_01966	A6QUU5	A6QX59	Uncharacterized protein.	Uncharacterized protein.	0.857
HCAG_01151	HCAG_02174	A6QUU5	A6QXR7	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.999
HCAG_01151	HCAG_02484	A6QUU5	A6QYM7	Uncharacterized protein.	Uncharacterized protein.	0.855
HCAG_01151	HCAG_05491	A6QUU5	A6R783	Uncharacterized protein.	Uncharacterized protein.	0.850
HCAG_01151	HCAG_06132	A6QUU5	A6RAZ4	Uncharacterized protein.	Uncharacterized protein.	0.869
HCAG_01151	HCAG_06159	A6QUU5	A6RB21	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.502
HCAG_01151	HCAG_08016	A6QUU5	A6REF1	Uncharacterized protein.	GLUE N-terminal domain-containing protein.	0.955
HCAG_01151	HCAG_08344	A6QUU5	A6RFC8	Uncharacterized protein.	Uncharacterized protein.	0.851
HCAG_01151	HCAG_08705	A6QUU5	A6RGD9	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.880
HCAG_01966	HCAG_01151	A6QX59	A6QUU5	Uncharacterized protein.	Uncharacterized protein.	0.857
HCAG_01966	HCAG_02174	A6QX59	A6QXR7	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.896
HCAG_01966	HCAG_02484	A6QX59	A6QYM7	Uncharacterized protein.	Uncharacterized protein.	0.986
HCAG_01966	HCAG_05491	A6QX59	A6R783	Uncharacterized protein.	Uncharacterized protein.	0.995
HCAG_01966	HCAG_06132	A6QX59	A6RAZ4	Uncharacterized protein.	Uncharacterized protein.	0.997
HCAG_01966	HCAG_08016	A6QX59	A6REF1	Uncharacterized protein.	GLUE N-terminal domain-containing protein.	0.979
HCAG_01966	HCAG_08344	A6QX59	A6RFC8	Uncharacterized protein.	Uncharacterized protein.	0.985
HCAG_01966	HCAG_08705	A6QX59	A6RGD9	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.980
HCAG_02174	HCAG_01151	A6QXR7	A6QUU5	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Uncharacterized protein.	0.999
HCAG_02174	HCAG_01966	A6QXR7	A6QX59	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Uncharacterized protein.	0.896
HCAG_02174	HCAG_02484	A6QXR7	A6QYM7	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	Uncharacterized protein.	0.869