(130 nodes) Carboxylic acid catabolic process network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_03336	Branched chain alpha-keto acid dehydrogenase E1 subunit beta. (390 aa)
	HCAG_09001	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (451 aa)
	HCAG_09000	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (585 aa)
	HCAG_08974	Nonspecific lipid-transfer protein, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (458 aa)
	HCAG_08892	Uncharacterized protein. (280 aa)
	HCAG_08662	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (516 aa)
	HCAG_08647	Uncharacterized protein. (434 aa)
	HCAG_08645	HTH APSES-type domain-containing protein. (484 aa)
	HCAG_08626	Uncharacterized protein. (633 aa)
	HCAG_08621	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	HCAG_08620	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (485 aa)
	HCAG_08561	Alcohol dehydrogenase I. (255 aa)
	HCAG_08510	Uncharacterized protein. (444 aa)
	HCAG_08470	Threonine aldolase. (374 aa)
	HCAG_08446	Uncharacterized protein. (626 aa)
	HCAG_08443	Uncharacterized protein. (265 aa)
	HCAG_08403	APH domain-containing protein. (256 aa)
	HCAG_08375	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (495 aa)
	HCAG_08367	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
	HCAG_08340	Uncharacterized protein. (170 aa)
	HCAG_08334	Uncharacterized protein. (295 aa)
	HCAG_08152	Glucosamine-6-phosphate isomerase. (294 aa)
	HCAG_08114	3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	HCAG_08086	Uncharacterized protein. (142 aa)
	HCAG_08085	Uncharacterized protein. (264 aa)
	HCAG_08058	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	HCAG_00029	Mitochondrial methylglutaconyl-CoA hydratase. (304 aa)
	HCAG_00045	Uncharacterized protein. (183 aa)
	HCAG_00081	DAO domain-containing protein. (482 aa)
	HCAG_00220	Cysteine dioxygenase. (213 aa)
	HCAG_00341	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa)
	HCAG_00349	D-lactate dehydrogenase 2, mitochondrial. (551 aa)
	HCAG_00676	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial. (585 aa)
	HCAG_00677	Isovaleryl-CoA dehydrogenase, mitochondrial. (434 aa)
	HCAG_00780	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
	HCAG_00814	Thiolase_C domain-containing protein. (126 aa)
	HCAG_01069	Uncharacterized protein. (544 aa)
	HCAG_01093	Uncharacterized protein. (296 aa)
	HCAG_01148	Uncharacterized protein. (481 aa)
	HCAG_01201	Fungal_trans domain-containing protein. (633 aa)
	HCAG_01490	Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (279 aa)
	HCAG_01491	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (481 aa)
	HCAG_01595	Uncharacterized protein. (242 aa)
	HCAG_01596	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	HCAG_01606	Acetyl-coenzyme A synthetase. (669 aa)
	HCAG_01683	4-hydroxyphenylpyruvate dioxygenase. (428 aa)
	HCAG_01711	Abhydrolase_3 domain-containing protein. (333 aa)
	HCAG_01780	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (579 aa)
	HCAG_01902	Uncharacterized protein. (248 aa)
	HCAG_01903	Zn(2)-C6 fungal-type domain-containing protein. (462 aa)
	HCAG_02120	Fumarylacetoacetase. (429 aa)
	HCAG_02125	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (491 aa)
	HCAG_02218	Uncharacterized protein. (316 aa)
	HCAG_02361	Nuclear elongation and deformation protein 1. (746 aa)
	HCAG_02371	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (478 aa)
	HCAG_02405	Uncharacterized protein. (236 aa)
	HCAG_02488	Uncharacterized protein. (471 aa)
	HCAG_02524	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (384 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (192 aa)
	HCAG_02805	Uncharacterized protein; Belongs to the TPP enzyme family. (604 aa)
	HCAG_02812	Uncharacterized protein. (167 aa)
	HCAG_02897	Sporulation protein SPS19. (316 aa)
	HCAG_02899	APH domain-containing protein. (215 aa)
	HCAG_03243	Uncharacterized protein. (501 aa)
	HCAG_03352	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (315 aa)
	HCAG_03373	Beta-lactamase domain-containing protein. (408 aa)
	HCAG_03386	Uncharacterized protein. (311 aa)
	HCAG_03455	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (143 aa)
	HCAG_03497	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (312 aa)
	HCAG_03522	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (452 aa)
	HCAG_03650	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1076 aa)
	HCAG_03803	Hydroxymethylglutaryl-CoA lyase, mitochondrial. (355 aa)
	HCAG_03813	Uncharacterized protein. (132 aa)
	HCAG_03847	Electron transfer flavoprotein subunit alpha. (348 aa)
	HCAG_03979	Uncharacterized protein. (316 aa)
	HCAG_04242	PALP domain-containing protein. (431 aa)
	HCAG_04373	FAD-binding PCMH-type domain-containing protein. (608 aa)
	HCAG_04480	Uncharacterized protein. (307 aa)
	HCAG_04514	Beta_elim_lyase domain-containing protein. (393 aa)
	HCAG_04545	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (534 aa)
	HCAG_04793	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (223 aa)
	HCAG_04818	ABC transporter domain-containing protein. (675 aa)
	HCAG_05020	Uncharacterized protein. (311 aa)
	HCAG_05038	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (550 aa)
	HCAG_05084	Malate synthase; Belongs to the malate synthase family. (539 aa)
	HCAG_05089	Isocitrate lyase. (600 aa)
	HCAG_05090	Citrate synthase; Belongs to the citrate synthase family. (470 aa)
	HCAG_05123	Amidase domain-containing protein. (535 aa)
	HCAG_05146	Uncharacterized protein. (274 aa)
	HCAG_05408	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (314 aa)
	HCAG_06346	APH domain-containing protein. (495 aa)
	HCAG_06758	Uncharacterized protein. (354 aa)
	HCAG_06845	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (385 aa)
	HCAG_05679	Aminotran_1_2 domain-containing protein. (495 aa)
	HCAG_05719	4-hydroxyphenylpyruvate dioxygenase. (402 aa)
	HCAG_05721	Homogentisate 1,2-dioxygenase. (454 aa)
	HCAG_05738	Pyruvate carboxyltransferase domain-containing protein. (433 aa)
	HCAG_05761	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (450 aa)
	HCAG_05815	Uncharacterized protein. (161 aa)
	HCAG_05837	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (466 aa)
	HCAG_05855	Uncharacterized protein. (477 aa)
	HCAG_05980	CoA carboxyltransferase C-terminal domain-containing protein. (399 aa)
	HCAG_06005	Uncharacterized protein; Belongs to the TPP enzyme family. (590 aa)
	HCAG_06059	Methylmalonate-semialdehyde dehydrogenase, mitochondrial. (567 aa)
	HCAG_06102	Aspartate aminotransferase. (429 aa)
	HCAG_06141	Acyl-CoA_ox_N domain-containing protein. (139 aa)
	HCAG_06190	Fungal_trans domain-containing protein. (362 aa)
	HCAG_06205	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
	HCAG_06229	Cytochrome b5 heme-binding domain-containing protein. (468 aa)
	HCAG_06245	Succinate-semialdehyde dehydrogenase. (497 aa)
	HCAG_06253	Threonine dehydratase. (540 aa)
	HCAG_06297	DAO domain-containing protein. (436 aa)
	HCAG_07024	Uncharacterized protein. (61 aa)
	HCAG_07123	Thiolase_N domain-containing protein. (228 aa)
	HCAG_07153	Uncharacterized protein. (458 aa)
	HCAG_07205	Beta_elim_lyase domain-containing protein. (418 aa)
	HCAG_07235	FAD-binding PCMH-type domain-containing protein. (568 aa)
	HCAG_07261	Uncharacterized protein. (486 aa)
	HCAG_07368	Uncharacterized protein. (182 aa)
	HCAG_07383	Uncharacterized protein. (594 aa)
	HCAG_07418	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (519 aa)
	HCAG_07571	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1122 aa)
	HCAG_07707	Uncharacterized protein. (485 aa)
	HCAG_07725	3-hydroxybutyryl-CoA dehydrogenase. (321 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	HCAG_07844	Ornithine aminotransferase. (458 aa)
	HCAG_07906	Glutaryl-CoA dehydrogenase, mitochondrial. (428 aa)
	HCAG_07925	Uncharacterized protein. (262 aa)
	HCAG_07944	Uncharacterized protein. (96 aa)
	HCAG_08039	MaoC-like domain-containing protein. (901 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A6QZE4	A6RDT4	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.859
BNA1	HCAG_01148	A6QZE4	A6QUU2	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.651
BNA1	HCAG_03497	A6QZE4	A6R1J0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.668
BNA1	HCAG_08085	A6QZE4	A6REM0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.980
BNA1	HCAG_08086	A6QZE4	A6REM1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.793
BNA4	BNA1	A6RDT4	A6QZE4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.859
BNA4	HCAG_01148	A6RDT4	A6QUU2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.637
BNA4	HCAG_01606	A6RDT4	A6QW49	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Acetyl-coenzyme A synthetase.	0.486
BNA4	HCAG_02120	A6RDT4	A6QXL3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Fumarylacetoacetase.	0.402
BNA4	HCAG_03497	A6RDT4	A6R1J0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.572
BNA4	HCAG_05721	A6RDT4	A6R9T3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Homogentisate 1,2-dioxygenase.	0.506
BNA4	HCAG_08085	A6RDT4	A6REM0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.992
BNA4	HCAG_08086	A6RDT4	A6REM1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.808
HCAG_00029	HCAG_00676	A6QRM3	A6QTH0	Mitochondrial methylglutaconyl-CoA hydratase.	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial.	0.950
HCAG_00029	HCAG_00677	A6QRM3	A6QTH1	Mitochondrial methylglutaconyl-CoA hydratase.	Isovaleryl-CoA dehydrogenase, mitochondrial.	0.647
HCAG_00029	HCAG_00780	A6QRM3	A6QTS4	Mitochondrial methylglutaconyl-CoA hydratase.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_00814	A6QRM3	A6QTV8	Mitochondrial methylglutaconyl-CoA hydratase.	Thiolase_C domain-containing protein.	0.585
HCAG_00029	HCAG_01201	A6QRM3	A6QUZ4	Mitochondrial methylglutaconyl-CoA hydratase.	Fungal_trans domain-containing protein.	0.509
HCAG_00029	HCAG_01596	A6QRM3	A6QW39	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_02405	A6QRM3	A6QYE8	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.594