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HCAG_09003 HCAG_09003 HCAG_08549 HCAG_08549 HCAG_08081 HCAG_08081 HCAG_07821 HCAG_07821 HCAG_07820 HCAG_07820 NTH1 NTH1 HCAG_07104 HCAG_07104 HCAG_05832 HCAG_05832 HCAG_05782 HCAG_05782 HCAG_05725 HCAG_05725 HCAG_06929 HCAG_06929 HCAG_06854 HCAG_06854 HCAG_06715 HCAG_06715 HCAG_06700 HCAG_06700 HCAG_06498 HCAG_06498 HCAG_05531 HCAG_05531 HCAG_05509 HCAG_05509 HCAG_05419 HCAG_05419 HCAG_05418 HCAG_05418 HCAG_05266 HCAG_05266 HCAG_04790 HCAG_04790 HCAG_04623 HCAG_04623 HCAG_03991 HCAG_03991 HCAG_03806 HCAG_03806 HCAG_03616 HCAG_03616 HCAG_03381 HCAG_03381 HCAG_03263 HCAG_03263 HCAG_02655 HCAG_02655 HCAG_02176 HCAG_02176 HCAG_02058 HCAG_02058 DRE2 DRE2 CIA1 CIA1 HCAG_01603 HCAG_01603 HCAG_09289 HCAG_09289 HCAG_01495 HCAG_01495 HCAG_01473 HCAG_01473 HCAG_01217 HCAG_01217 HCAG_01162 HCAG_01162 HCAG_01161 HCAG_01161 HCAG_01033 HCAG_01033 HCAG_01032 HCAG_01032 NBP35 NBP35 HCAG_00552 HCAG_00552 HCAG_00085 HCAG_00085
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCAG_09003Flavodoxin-like domain-containing protein. (809 aa)
HCAG_08549Elp3 domain-containing protein. (449 aa)
HCAG_08081Fe-S_biosyn domain-containing protein. (230 aa)
HCAG_078212-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (596 aa)
HCAG_07820Uncharacterized protein. (925 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (532 aa)
HCAG_071043-isopropylmalate dehydratase. (714 aa)
HCAG_05832Zn(2)-C6 fungal-type domain-containing protein. (457 aa)
HCAG_05782Uncharacterized protein. (341 aa)
HCAG_05725Biotin synthase. (398 aa)
HCAG_06929NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial. (756 aa)
HCAG_06854Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (797 aa)
HCAG_06715DNA repair helicase RAD3. (683 aa)
HCAG_06700Uncharacterized protein. (946 aa)
HCAG_06498DNA polymerase. (1086 aa)
HCAG_05531Uncharacterized protein. (390 aa)
HCAG_05509NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial. (225 aa)
HCAG_05419DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (774 aa)
HCAG_05418DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (821 aa)
HCAG_05266Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (763 aa)
HCAG_04790DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (536 aa)
HCAG_04623NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial; Belongs to the complex I 49 kDa subunit family. (479 aa)
HCAG_03991NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial; Belongs to the complex I 20 kDa subunit family. (242 aa)
HCAG_038062-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (425 aa)
HCAG_03616Nfu_N domain-containing protein. (279 aa)
HCAG_03381ATP-binding cassette sub-family E member 1. (638 aa)
HCAG_03263Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (283 aa)
HCAG_02655Uncharacterized protein. (203 aa)
HCAG_02176Molybdenum cofactor biosynthesis protein 1 A. (747 aa)
HCAG_02058SAE2 domain-containing protein. (1088 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (351 aa)
CIA1Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (491 aa)
HCAG_01603NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (419 aa)
HCAG_09289Flavodoxin-like domain-containing protein. (448 aa)
HCAG_01495Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (630 aa)
HCAG_01473Uncharacterized protein. (1332 aa)
HCAG_01217Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (465 aa)
HCAG_01162Uncharacterized protein. (429 aa)
HCAG_01161DNA_pol_B_exo1 domain-containing protein. (430 aa)
HCAG_01033POR_N domain-containing protein. (506 aa)
HCAG_01032Uncharacterized protein. (173 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa)
HCAG_00552Uncharacterized protein. (328 aa)
HCAG_00085Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (643 aa)
Your Current Organism:
Histoplasma capsulatum NAm1
NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1
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