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HCAG_07624 HCAG_07624 HCAG_00034 HCAG_00034 HCAG_00215 HCAG_00215 TRM5 TRM5 HCAG_00539 HCAG_00539 HCAG_00606 HCAG_00606 HCAG_00616 HCAG_00616 HCAG_00617 HCAG_00617 HCAG_00710 HCAG_00710 HCAG_00794 HCAG_00794 HCAG_00811 HCAG_00811 HCAG_00838 HCAG_00838 HCAG_00849 HCAG_00849 HCAG_00904 HCAG_00904 HCAG_00984 HCAG_00984 HCAG_01474 HCAG_01474 HCAG_01480 HCAG_01480 HCAG_01736 HCAG_01736 ALA1 ALA1 HCAG_01919 HCAG_01919 HCAG_01988 HCAG_01988 HCAG_02062 HCAG_02062 HCAG_02159 HCAG_02159 HCAG_02192 HCAG_02192 HCAG_02195 HCAG_02195 HCAG_02216 HCAG_02216 DUS3 DUS3 HCAG_02596 HCAG_02596 HCAG_02762 HCAG_02762 HCAG_02764 HCAG_02764 HCAG_02983 HCAG_02983 HCAG_03017 HCAG_03017 HCAG_03042 HCAG_03042 HCAG_03112 HCAG_03112 HCAG_03176 HCAG_03176 HCAG_03189 HCAG_03189 HCAG_03590 HCAG_03590 HCAG_03759 HCAG_03759 HCAG_03866 HCAG_03866 HCAG_03882 HCAG_03882 HCAG_04243 HCAG_04243 HCAG_04244 HCAG_04244 HCAG_04312 HCAG_04312 HCAG_04360 HCAG_04360 HCAG_04499 HCAG_04499 HCAG_04705 HCAG_04705 TRM82 TRM82 HCAG_04922 HCAG_04922 HCAG_04935 HCAG_04935 HCAG_05060 HCAG_05060 HCAG_05068 HCAG_05068 HCAG_05096 HCAG_05096 HCAG_05151 HCAG_05151 HCAG_05229 HCAG_05229 HCAG_05328 HCAG_05328 HCAG_05386 HCAG_05386 HCAG_05427 HCAG_05427 HCAG_05450 HCAG_05450 HCAG_06432 HCAG_06432 HCAG_06645 HCAG_06645 HCAG_06692 HCAG_06692 HCAG_06694 HCAG_06694 HCAG_06738 HCAG_06738 HCAG_06841 HCAG_06841 HCAG_06876 HCAG_06876 HCAG_06906 HCAG_06906 HCAG_05713 HCAG_05713 HCAG_05733 HCAG_05733 HCAG_05882 HCAG_05882 HCAG_05931 HCAG_05931 HCAG_06072 HCAG_06072 HCAG_06100 HCAG_06100 TRM8 TRM8 HCAG_06232 HCAG_06232 HCAG_06243 HCAG_06243 HCAG_07283 HCAG_07283 HCAG_07635 HCAG_07635 HCAG_07819 HCAG_07819 HCAG_07965 HCAG_07965 HCAG_07998 HCAG_07998 HCAG_08250 HCAG_08250 HCAG_08409 HCAG_08409 HCAG_08834 HCAG_08834 HCAG_09003 HCAG_09003
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCAG_07624Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (527 aa)
HCAG_00034Uncharacterized protein. (305 aa)
HCAG_00215Phenylalanyl-tRNA synthetase. (631 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (471 aa)
HCAG_00539Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (465 aa)
HCAG_00606tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (383 aa)
HCAG_00616tRNA-synt_1e domain-containing protein. (665 aa)
HCAG_00617Uncharacterized protein. (509 aa)
HCAG_00710ThiF domain-containing protein. (514 aa)
HCAG_00794Uncharacterized protein. (158 aa)
HCAG_00811Uncharacterized protein. (125 aa)
HCAG_00838tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. (504 aa)
HCAG_00849Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (475 aa)
HCAG_00904tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
HCAG_00984Asparaginyl-tRNA synthetase. (581 aa)
HCAG_01474Uncharacterized protein. (92 aa)
HCAG_01480UPF0020 domain-containing protein. (432 aa)
HCAG_01736AA_TRNA_LIGASE_II domain-containing protein. (523 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (910 aa)
HCAG_01919GST C-terminal domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (670 aa)
HCAG_01988tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (638 aa)
HCAG_02062Methyltransf_11 domain-containing protein. (234 aa)
HCAG_02159TRUD domain-containing protein. (726 aa)
HCAG_02192Uncharacterized protein. (1131 aa)
HCAG_02195Uncharacterized protein. (584 aa)
HCAG_02216AA_TRNA_LIGASE_II domain-containing protein. (582 aa)
DUS3tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). (741 aa)
HCAG_02596TruB_N domain-containing protein. (450 aa)
HCAG_02762Uncharacterized protein. (316 aa)
HCAG_02764Valyl-tRNA synthetase 2; Belongs to the class-I aminoacyl-tRNA synthetase family. (614 aa)
HCAG_02983ANK_REP_REGION domain-containing protein. (651 aa)
HCAG_03017Glycyl-tRNA synthetase 1. (582 aa)
HCAG_03042Uncharacterized protein. (193 aa)
HCAG_03112Seryl-tRNA synthetase. (415 aa)
HCAG_03176TYW3 domain-containing protein. (360 aa)
HCAG_03189Uncharacterized protein. (984 aa)
HCAG_03590AA_TRNA_LIGASE_II domain-containing protein. (569 aa)
HCAG_03759Uncharacterized protein. (542 aa)
HCAG_03866Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (517 aa)
HCAG_03882Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (596 aa)
HCAG_04243Uncharacterized protein. (206 aa)
HCAG_04244tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (324 aa)
HCAG_04312Uncharacterized protein. (461 aa)
HCAG_04360SAM-dependent MTase TRM10-type domain-containing protein. (403 aa)
HCAG_04499Phenylalanyl-tRNA synthetase alpha chain. (521 aa)
HCAG_04705AA_TRNA_LIGASE_II domain-containing protein. (973 aa)
TRM82tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (552 aa)
HCAG_04922tRNA_int_end_N2 domain-containing protein. (506 aa)
HCAG_04935Uncharacterized protein. (120 aa)
HCAG_05060Uncharacterized protein. (206 aa)
HCAG_05068Uncharacterized protein. (629 aa)
HCAG_05096Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (699 aa)
HCAG_05151RF_PROK_I domain-containing protein. (187 aa)
HCAG_05229Leucyl-tRNA synthetase. (1081 aa)
HCAG_05328Aspartyl-tRNA synthetase. (756 aa)
HCAG_05386Uncharacterized protein. (239 aa)
HCAG_05427AA_TRNA_LIGASE_II domain-containing protein. (523 aa)
HCAG_05450RF_PROK_I domain-containing protein. (195 aa)
HCAG_06432tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (504 aa)
HCAG_06645Seryl_tRNA_N domain-containing protein. (466 aa)
HCAG_06692Sfi1 domain-containing protein. (742 aa)
HCAG_06694Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1034 aa)
HCAG_06738SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (553 aa)
HCAG_06841Leucyl-tRNA synthetase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (834 aa)
HCAG_06876Uncharacterized protein. (221 aa)
HCAG_06906Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (377 aa)
HCAG_05713Lysine--tRNA ligase. (609 aa)
HCAG_05733Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (372 aa)
HCAG_05882Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (390 aa)
HCAG_05931Tyrosine--tRNA ligase. (399 aa)
HCAG_06072Uncharacterized protein. (333 aa)
HCAG_06100Uncharacterized protein. (186 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (344 aa)
HCAG_06232AA_TRNA_LIGASE_II domain-containing protein. (680 aa)
HCAG_06243Tyrosine--tRNA ligase. (490 aa)
HCAG_07283AA_TRNA_LIGASE_II domain-containing protein. (551 aa)
HCAG_07635Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (797 aa)
HCAG_07819Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (277 aa)
HCAG_07965Uncharacterized protein. (1506 aa)
HCAG_07998Queuine tRNA-ribosyltransferase. (369 aa)
HCAG_08250Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (650 aa)
HCAG_08409Uncharacterized protein. (534 aa)
HCAG_08834D-aminoacyl-tRNA deacylase. (191 aa)
HCAG_09003Flavodoxin-like domain-containing protein. (809 aa)
Your Current Organism:
Histoplasma capsulatum NAm1
NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1
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