(8 nodes) Recycling pathway of L1 network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	HCAG_04225	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1631 aa)
	HCAG_02979	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (478 aa)
	HCAG_01328	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (253 aa)
	HCAG_00950	Rad60-SLD_2 domain-containing protein. (288 aa)
	HCAG_08087	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (692 aa)
	HCAG_07753	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (993 aa)
	HCAG_06724	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	HCAG_04363	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (711 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00950	HCAG_01328	A6QU94	A6QVC1	Rad60-SLD_2 domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.784
HCAG_00950	HCAG_02979	A6QU94	A6R022	Rad60-SLD_2 domain-containing protein.	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.921
HCAG_00950	HCAG_04225	A6QU94	A6R3L7	Rad60-SLD_2 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.914
HCAG_00950	HCAG_06724	A6QU94	A6R8T3	Rad60-SLD_2 domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.911
HCAG_00950	HCAG_07753	A6QU94	A6RDP5	Rad60-SLD_2 domain-containing protein.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.778
HCAG_01328	HCAG_00950	A6QVC1	A6QU94	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Rad60-SLD_2 domain-containing protein.	0.784
HCAG_01328	HCAG_02979	A6QVC1	A6R022	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.894
HCAG_01328	HCAG_04225	A6QVC1	A6R3L7	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.999
HCAG_01328	HCAG_04363	A6QVC1	A6R405	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.784
HCAG_01328	HCAG_06724	A6QVC1	A6R8T3	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.884
HCAG_01328	HCAG_07753	A6QVC1	A6RDP5	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.726
HCAG_01328	HCAG_08087	A6QVC1	A6REM2	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.784
HCAG_02979	HCAG_00950	A6R022	A6QU94	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Rad60-SLD_2 domain-containing protein.	0.921
HCAG_02979	HCAG_01328	A6R022	A6QVC1	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.894
HCAG_02979	HCAG_04225	A6R022	A6R3L7	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.926
HCAG_02979	HCAG_04363	A6R022	A6R405	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.921
HCAG_02979	HCAG_06724	A6R022	A6R8T3	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
HCAG_02979	HCAG_07753	A6R022	A6RDP5	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.998
HCAG_02979	HCAG_08087	A6R022	A6REM2	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.991
HCAG_04225	HCAG_00950	A6R3L7	A6QU94	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Rad60-SLD_2 domain-containing protein.	0.914