(41 nodes) RNA Polymerase II Transcription Elongation network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_04864	DNA-directed RNA polymerases I. (177 aa)
	HCAG_04441	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1743 aa)
	HCAG_04046	Serine/threonine-protein kinase crk1; Belongs to the protein kinase superfamily. (408 aa)
	HCAG_03784	Uncharacterized protein. (123 aa)
	HCAG_03460	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1424 aa)
	HCAG_03433	TFIIS N-terminal domain-containing protein. (423 aa)
	HCAG_03024	Uncharacterized protein. (1227 aa)
	HCAG_02903	CYCLIN domain-containing protein; Belongs to the cyclin family. (491 aa)
	HCAG_02833	Uncharacterized protein. (369 aa)
	HCAG_02811	Uncharacterized protein. (169 aa)
	HCAG_02810	Uncharacterized protein. (524 aa)
	HCAG_02364	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1747 aa)
	HCAG_01970	Uncharacterized protein. (334 aa)
	HCAG_01528	Uncharacterized protein. (644 aa)
	HCAG_01496	Uncharacterized protein. (75 aa)
	HCAG_01484	TPR_REGION domain-containing protein. (402 aa)
	HCAG_00906	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (129 aa)
	HCAG_00846	Uncharacterized protein. (413 aa)
	HCAG_00645	Uncharacterized protein. (296 aa)
	HCAG_00496	Uncharacterized protein. (750 aa)
	HCAG_00244	RPOL4c domain-containing protein. (152 aa)
	HCAG_00038	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (654 aa)
	HCAG_08910	DNA repair protein Rex1. (72 aa)
	HCAG_08845	Plus3 domain-containing protein. (637 aa)
	HCAG_08810	Uncharacterized protein. (684 aa)
	HCAG_08376	Spt4 domain-containing protein. (204 aa)
	HCAG_08069	Uncharacterized protein. (544 aa)
	HCAG_07886	Uncharacterized protein. (279 aa)
	HCAG_07839	CDC73_C domain-containing protein. (519 aa)
	HCAG_07759	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (455 aa)
	HCAG_07638	Uncharacterized protein. (720 aa)
	HCAG_07360	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (104 aa)
	HCAG_07341	Nuclear cap-binding protein subunit 2. (171 aa)
	HCAG_07073	RING-type domain-containing protein. (379 aa)
	HCAG_06230	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1080 aa)
	HCAG_05932	RPOLD domain-containing protein. (576 aa)
	HCAG_06934	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (506 aa)
	HCAG_06885	Uncharacterized protein. (796 aa)
	HCAG_06734	DNA-directed RNA polymerases II 24 kDa polypeptide. (236 aa)
	HCAG_06715	DNA repair helicase RAD3. (683 aa)
	HCAG_06417	DNA-directed RNA polymerase II 13.3 kDa polypeptide. (168 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00038	HCAG_00244	A6QRN2	A6QS88	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOL4c domain-containing protein.	0.931
HCAG_00038	HCAG_00645	A6QRN2	A6QTD9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.598
HCAG_00038	HCAG_00906	A6QRN2	A6QU50	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.742
HCAG_00038	HCAG_01496	A6QRN2	A6QVT9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.748
HCAG_00038	HCAG_02364	A6QRN2	A6QYA7	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.988
HCAG_00038	HCAG_02810	A6QRN2	A6QZK3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.886
HCAG_00038	HCAG_02811	A6QRN2	A6QZK4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.957
HCAG_00038	HCAG_02833	A6QRN2	A6QZM6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.932
HCAG_00038	HCAG_02903	A6QRN2	A6QZU6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.717
HCAG_00038	HCAG_03433	A6QRN2	A6R1C6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	TFIIS N-terminal domain-containing protein.	0.919
HCAG_00038	HCAG_03460	A6QRN2	A6R1F3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.939
HCAG_00038	HCAG_03784	A6QRN2	A6R2C6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.660
HCAG_00038	HCAG_04046	A6QRN2	A6R338	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Serine/threonine-protein kinase crk1; Belongs to the protein kinase superfamily.	0.842
HCAG_00038	HCAG_04441	A6QRN2	A6R483	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.934
HCAG_00038	HCAG_04864	A6QRN2	A6R5F6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerases I.	0.836
HCAG_00038	HCAG_05932	A6QRN2	A6RAE4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOLD domain-containing protein.	0.966
HCAG_00038	HCAG_06230	A6QRN2	A6RB92	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.882
HCAG_00038	HCAG_06417	A6QRN2	A6R7X6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerase II 13.3 kDa polypeptide.	0.886
HCAG_00038	HCAG_06734	A6QRN2	A6R8U3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerases II 24 kDa polypeptide.	0.810
HCAG_00038	HCAG_06885	A6QRN2	A6R994	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.687