(52 nodes) Purine metabolism network (Histoplasma capsulatum NAm1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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	HCAG_00049	TR_THY domain-containing protein. (188 aa)
	HCAG_00440	Phosphoribosylformylglycinamidine synthase. (1362 aa)
	HCAG_00517	A_deaminase domain-containing protein. (565 aa)
	HCAG_00533	DHHA2 domain-containing protein. (456 aa)
	HCAG_00544	Nucleoside diphosphate kinase. (152 aa)
	HCAG_01176	Pyruvate dehydrogenase kinase. (303 aa)
	MET3	Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the N-terminal section; belongs to the sulfate adenylyltransferase family. (573 aa)
	HCAG_01433	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (478 aa)
	HCAG_01659	Xanthine dehydrogenase. (1359 aa)
	HCAG_01667	Ribose-phosphate pyrophosphokinase 3. (297 aa)
	HCAG_01742	Adenylyl-sulfate kinase. (155 aa)
	HCAG_01878	AMP deaminase 2. (1042 aa)
	HCAG_02007	Guanylate kinase. (200 aa)
	HCAG_02112	Adenine phosphoribosyltransferase 1. (214 aa)
	HCAG_02160	GMP synthase subunit B. (543 aa)
	HCAG_02604	Uncharacterized protein. (255 aa)
	HCAG_02757	Uncharacterized protein. (203 aa)
	HCAG_02773	ATP_transf domain-containing protein. (401 aa)
	HCAG_03103	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (177 aa)
	HCAG_03104	Uncharacterized protein. (151 aa)
	HCAG_03597	Urease. (999 aa)
	HCAG_03754	Uncharacterized protein. (1014 aa)
	HCAG_03809	Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (556 aa)
	HCAG_03976	Ribose-phosphate pyrophosphokinase. (381 aa)
	HCAG_04224	Bifunctional purine biosynthesis protein ADE17. (626 aa)
	HCAG_04495	Inosine-5'-monophosphate dehydrogenase. (508 aa)
	HCAG_04774	Formyl_trans_N domain-containing protein. (234 aa)
	ADK2	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (275 aa)
	HCAG_05097	Amidophosphoribosyltransferase. (604 aa)
	HCAG_05202	Uncharacterized protein. (1116 aa)
	HCAG_05394	Allantoinase. (592 aa)
	HCAG_05637	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (508 aa)
	HCAG_06648	Uncharacterized protein. (382 aa)
	HCAG_06743	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (422 aa)
	HCAG_06816	Ribose-phosphate pyrophosphokinase I. (456 aa)
	HCAG_06867	Xanthine dehydrogenase. (1386 aa)
	HCAG_06908	Purine nucleoside phosphorylase. (347 aa)
	HCAG_07176	Bis(5'-adenosyl)-triphosphatase. (205 aa)
	HCAG_07493	IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. (430 aa)
	HCAG_07570	Uncharacterized protein. (821 aa)
	HCAG_07781	Pyruvate kinase; Belongs to the pyruvate kinase family. (542 aa)
	HCAG_08056	A_deaminase domain-containing protein. (587 aa)
	HCAG_08071	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (318 aa)
	HCAG_08405	Nudix hydrolase domain-containing protein. (299 aa)
	HCAG_08406	ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. (227 aa)
	HCAG_08468	A_deaminase domain-containing protein. (348 aa)
	HCAG_08512	Adenosine kinase. (374 aa)
	HCAG_08689	Phosphoribosylformylglycinamidine cyclo-ligase. (797 aa)
	HCAG_08808	Phosphoglucomutase; Belongs to the phosphohexose mutase family. (556 aa)
	HCAG_08824	Uncharacterized protein. (642 aa)
	ADK1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (277 aa)
	HCAG_09248	RIBORED_LARGE domain-containing protein. (524 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK1	ADK2	A6RHI1	A6R583	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.910
ADK1	HCAG_00544	A6RHI1	A6QT38	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nucleoside diphosphate kinase.	0.961
ADK1	HCAG_01433	A6RHI1	A6QVM6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.966
ADK1	HCAG_01878	A6RHI1	A6QWX1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	AMP deaminase 2.	0.936
ADK1	HCAG_02007	A6RHI1	A6QXA0	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Guanylate kinase.	0.761
ADK1	HCAG_02112	A6RHI1	A6QXK5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenine phosphoribosyltransferase 1.	0.973
ADK1	HCAG_02604	A6RHI1	A6QYZ7	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Uncharacterized protein.	0.950
ADK1	HCAG_03103	A6RHI1	A6R0E6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.	0.920
ADK1	HCAG_04224	A6RHI1	A6R3L6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Bifunctional purine biosynthesis protein ADE17.	0.542
ADK1	HCAG_05637	A6RHI1	A6R7M9	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.943
ADK1	HCAG_07781	A6RHI1	A6RDS3	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.927
ADK1	HCAG_08512	A6RHI1	A6RFU6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Adenosine kinase.	0.970
ADK1	HCAG_09248	A6RHI1	A6XPE4	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	RIBORED_LARGE domain-containing protein.	0.943
ADK2	ADK1	A6R583	A6RHI1	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.910
ADK2	HCAG_00544	A6R583	A6QT38	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Nucleoside diphosphate kinase.	0.961
ADK2	HCAG_01433	A6R583	A6QVM6	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.966
ADK2	HCAG_01878	A6R583	A6QWX1	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	AMP deaminase 2.	0.914
ADK2	HCAG_02007	A6R583	A6QXA0	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Guanylate kinase.	0.708
ADK2	HCAG_02112	A6R583	A6QXK5	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Adenine phosphoribosyltransferase 1.	0.964
ADK2	HCAG_02604	A6R583	A6QYZ7	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Uncharacterized protein.	0.946