(31 nodes) Valine, leucine and isoleucine degradation network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00029	Mitochondrial methylglutaconyl-CoA hydratase. (304 aa)
	HCAG_00472	AMP-binding domain-containing protein. (658 aa)
	HCAG_00676	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial. (585 aa)
	HCAG_00677	Isovaleryl-CoA dehydrogenase, mitochondrial. (434 aa)
	HCAG_00678	Uncharacterized protein. (722 aa)
	HCAG_00780	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
	HCAG_01093	Uncharacterized protein. (296 aa)
	HCAG_01294	Uncharacterized protein. (747 aa)
	HCAG_01491	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (481 aa)
	HCAG_01596	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	HCAG_02524	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (384 aa)
	HCAG_03256	Uncharacterized protein. (444 aa)
	HCAG_03302	Uncharacterized protein. (378 aa)
	HCAG_03336	Branched chain alpha-keto acid dehydrogenase E1 subunit beta. (390 aa)
	HCAG_03803	Hydroxymethylglutaryl-CoA lyase, mitochondrial. (355 aa)
	HCAG_05311	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (491 aa)
	HCAG_05738	Pyruvate carboxyltransferase domain-containing protein. (433 aa)
	HCAG_05761	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (450 aa)
	HCAG_06059	Methylmalonate-semialdehyde dehydrogenase, mitochondrial. (567 aa)
	HCAG_06205	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
	HCAG_07123	Thiolase_N domain-containing protein. (228 aa)
	HCAG_08058	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	HCAG_08114	3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	HCAG_08367	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
	HCAG_08375	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (495 aa)
	HCAG_08510	Uncharacterized protein. (444 aa)
	HCAG_08621	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	HCAG_08647	Uncharacterized protein. (434 aa)
	HCAG_08805	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (475 aa)
	HCAG_08825	Dihydrolipoyl dehydrogenase. (515 aa)
	HCAG_08945	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (339 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00029	HCAG_00676	A6QRM3	A6QTH0	Mitochondrial methylglutaconyl-CoA hydratase.	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial.	0.950
HCAG_00029	HCAG_00677	A6QRM3	A6QTH1	Mitochondrial methylglutaconyl-CoA hydratase.	Isovaleryl-CoA dehydrogenase, mitochondrial.	0.647
HCAG_00029	HCAG_00678	A6QRM3	A6QTH2	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.959
HCAG_00029	HCAG_00780	A6QRM3	A6QTS4	Mitochondrial methylglutaconyl-CoA hydratase.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_01596	A6QRM3	A6QW39	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_02524	A6QRM3	A6QYR7	Mitochondrial methylglutaconyl-CoA hydratase.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.465
HCAG_00029	HCAG_03256	A6QRM3	A6R0U9	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.652
HCAG_00029	HCAG_03803	A6QRM3	A6R2E5	Mitochondrial methylglutaconyl-CoA hydratase.	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	0.965
HCAG_00029	HCAG_05311	A6QRM3	A6R6Q3	Mitochondrial methylglutaconyl-CoA hydratase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.432
HCAG_00029	HCAG_05738	A6QRM3	A6R9V0	Mitochondrial methylglutaconyl-CoA hydratase.	Pyruvate carboxyltransferase domain-containing protein.	0.959
HCAG_00029	HCAG_07123	A6QRM3	A6RBW5	Mitochondrial methylglutaconyl-CoA hydratase.	Thiolase_N domain-containing protein.	0.615
HCAG_00029	HCAG_08114	A6QRM3	A6REP9	Mitochondrial methylglutaconyl-CoA hydratase.	3-ketoacyl-CoA thiolase B; Belongs to the thiolase-like superfamily. Thiolase family.	0.615
HCAG_00029	HCAG_08621	A6QRM3	A6RG55	Mitochondrial methylglutaconyl-CoA hydratase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.585
HCAG_00029	HCAG_08647	A6QRM3	A6RG81	Mitochondrial methylglutaconyl-CoA hydratase.	Uncharacterized protein.	0.494
HCAG_00029	HCAG_08805	A6QRM3	A6RGN8	Mitochondrial methylglutaconyl-CoA hydratase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.937
HCAG_00472	HCAG_00780	A6QSW6	A6QTS4	AMP-binding domain-containing protein.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.456
HCAG_00472	HCAG_01294	A6QSW6	A6QV87	AMP-binding domain-containing protein.	Uncharacterized protein.	0.909
HCAG_00472	HCAG_01596	A6QSW6	A6QW39	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.456
HCAG_00472	HCAG_03803	A6QSW6	A6R2E5	AMP-binding domain-containing protein.	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	0.942
HCAG_00472	HCAG_05311	A6QSW6	A6R6Q3	AMP-binding domain-containing protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.917