(13 nodes) Valine, leucine and isoleucine biosynthesis network (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	HCAG_00104	Acetolactate synthase. (610 aa)
	HCAG_02260	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
	HCAG_03302	Uncharacterized protein. (378 aa)
	HCAG_04000	Dihydroxy-acid dehydratase. (611 aa)
	HCAG_04242	PALP domain-containing protein. (431 aa)
	HCAG_04577	Dihydroxy-acid dehydratase. (499 aa)
	HCAG_05584	Mitochondrial acetolactate synthase small subunit. (336 aa)
	HCAG_06253	Threonine dehydratase. (540 aa)
	HCAG_07104	3-isopropylmalate dehydratase. (714 aa)
	HCAG_07634	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (374 aa)
	HCAG_08889	PALP domain-containing protein. (411 aa)
	HCAG_08890	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (433 aa)
	HCAG_08945	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (339 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00104	HCAG_02260	A6QRU8	A6QY03	Acetolactate synthase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.948
HCAG_00104	HCAG_03302	A6QRU8	A6R0Z5	Acetolactate synthase.	Uncharacterized protein.	0.717
HCAG_00104	HCAG_04000	A6QRU8	A6R2Z2	Acetolactate synthase.	Dihydroxy-acid dehydratase.	0.847
HCAG_00104	HCAG_04242	A6QRU8	A6R3N4	Acetolactate synthase.	PALP domain-containing protein.	0.971
HCAG_00104	HCAG_04577	A6QRU8	A6R4L9	Acetolactate synthase.	Dihydroxy-acid dehydratase.	0.843
HCAG_00104	HCAG_05584	A6QRU8	A6R7H6	Acetolactate synthase.	Mitochondrial acetolactate synthase small subunit.	0.999
HCAG_00104	HCAG_06253	A6QRU8	A6RBB5	Acetolactate synthase.	Threonine dehydratase.	0.979
HCAG_00104	HCAG_07104	A6QRU8	A6RBU6	Acetolactate synthase.	3-isopropylmalate dehydratase.	0.694
HCAG_00104	HCAG_07634	A6QRU8	A6RDC6	Acetolactate synthase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.948
HCAG_00104	HCAG_08889	A6QRU8	A6RGX2	Acetolactate synthase.	PALP domain-containing protein.	0.941
HCAG_00104	HCAG_08890	A6QRU8	A6RGX3	Acetolactate synthase.	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family.	0.984
HCAG_00104	HCAG_08945	A6QRU8	A6RH28	Acetolactate synthase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.752
HCAG_02260	HCAG_00104	A6QY03	A6QRU8	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Acetolactate synthase.	0.948
HCAG_02260	HCAG_04000	A6QY03	A6R2Z2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Dihydroxy-acid dehydratase.	0.520
HCAG_02260	HCAG_04242	A6QY03	A6R3N4	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	PALP domain-containing protein.	0.913
HCAG_02260	HCAG_04577	A6QY03	A6R4L9	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Dihydroxy-acid dehydratase.	0.520
HCAG_02260	HCAG_05584	A6QY03	A6R7H6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Mitochondrial acetolactate synthase small subunit.	0.967
HCAG_02260	HCAG_06253	A6QY03	A6RBB5	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Threonine dehydratase.	0.913
HCAG_02260	HCAG_07104	A6QY03	A6RBU6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydratase.	0.995
HCAG_02260	HCAG_07634	A6QY03	A6RDC6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.903