(17 nodes) Butanoate metabolism network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	HCAG_00104	Acetolactate synthase. (610 aa)
	HCAG_00472	AMP-binding domain-containing protein. (658 aa)
	HCAG_01294	Uncharacterized protein. (747 aa)
	HCAG_03803	Hydroxymethylglutaryl-CoA lyase, mitochondrial. (355 aa)
	HCAG_05038	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (550 aa)
	HCAG_05311	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (491 aa)
	HCAG_05584	Mitochondrial acetolactate synthase small subunit. (336 aa)
	HCAG_06585	Uncharacterized protein. (590 aa)
	HCAG_05738	Pyruvate carboxyltransferase domain-containing protein. (433 aa)
	HCAG_06023	DAO domain-containing protein. (494 aa)
	HCAG_06245	Succinate-semialdehyde dehydrogenase. (497 aa)
	HCAG_07725	3-hydroxybutyryl-CoA dehydrogenase. (321 aa)
	HCAG_08058	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (293 aa)
	HCAG_08375	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (495 aa)
	HCAG_08621	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	HCAG_08662	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (516 aa)
	HCAG_08805	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (475 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00104	HCAG_03803	A6QRU8	A6R2E5	Acetolactate synthase.	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	0.428
HCAG_00104	HCAG_05584	A6QRU8	A6R7H6	Acetolactate synthase.	Mitochondrial acetolactate synthase small subunit.	0.999
HCAG_00104	HCAG_05738	A6QRU8	A6R9V0	Acetolactate synthase.	Pyruvate carboxyltransferase domain-containing protein.	0.428
HCAG_00472	HCAG_01294	A6QSW6	A6QV87	AMP-binding domain-containing protein.	Uncharacterized protein.	0.909
HCAG_00472	HCAG_03803	A6QSW6	A6R2E5	AMP-binding domain-containing protein.	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	0.942
HCAG_00472	HCAG_05311	A6QSW6	A6R6Q3	AMP-binding domain-containing protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.917
HCAG_00472	HCAG_05738	A6QSW6	A6R9V0	AMP-binding domain-containing protein.	Pyruvate carboxyltransferase domain-containing protein.	0.932
HCAG_00472	HCAG_06245	A6QSW6	A6RBA7	AMP-binding domain-containing protein.	Succinate-semialdehyde dehydrogenase.	0.473
HCAG_00472	HCAG_07725	A6QSW6	A6RDL7	AMP-binding domain-containing protein.	3-hydroxybutyryl-CoA dehydrogenase.	0.947
HCAG_00472	HCAG_08621	A6QSW6	A6RG55	AMP-binding domain-containing protein.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.945
HCAG_00472	HCAG_08805	A6QSW6	A6RGN8	AMP-binding domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.922
HCAG_01294	HCAG_00472	A6QV87	A6QSW6	Uncharacterized protein.	AMP-binding domain-containing protein.	0.909
HCAG_01294	HCAG_03803	A6QV87	A6R2E5	Uncharacterized protein.	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	0.943
HCAG_01294	HCAG_05311	A6QV87	A6R6Q3	Uncharacterized protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.917
HCAG_01294	HCAG_05738	A6QV87	A6R9V0	Uncharacterized protein.	Pyruvate carboxyltransferase domain-containing protein.	0.932
HCAG_01294	HCAG_06245	A6QV87	A6RBA7	Uncharacterized protein.	Succinate-semialdehyde dehydrogenase.	0.473
HCAG_01294	HCAG_07725	A6QV87	A6RDL7	Uncharacterized protein.	3-hydroxybutyryl-CoA dehydrogenase.	0.947
HCAG_01294	HCAG_08621	A6QV87	A6RG55	Uncharacterized protein.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.945
HCAG_01294	HCAG_08805	A6QV87	A6RGN8	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.922
HCAG_03803	HCAG_00104	A6R2E5	A6QRU8	Hydroxymethylglutaryl-CoA lyase, mitochondrial.	Acetolactate synthase.	0.428