(35 nodes) Nucleotide excision repair network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00496	Uncharacterized protein. (750 aa)
	HCAG_00846	Uncharacterized protein. (413 aa)
	HCAG_01084	Uncharacterized protein. (247 aa)
	HCAG_01094	CPSF_A domain-containing protein. (1158 aa)
	HCAG_01528	Uncharacterized protein. (644 aa)
	HCAG_02026	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (549 aa)
	HCAG_02903	CYCLIN domain-containing protein; Belongs to the cyclin family. (491 aa)
	HCAG_03036	Zf-rbx1 domain-containing protein. (125 aa)
	HCAG_03230	ERCC4 domain-containing protein. (876 aa)
	HCAG_03337	Uncharacterized protein. (1111 aa)
	HCAG_03626	DNA_pol_E_B domain-containing protein. (748 aa)
	HCAG_03825	Activator 1 38 kDa subunit. (352 aa)
	HCAG_03830	Replication factor C subunit 1. (1066 aa)
	HCAG_04046	Serine/threonine-protein kinase crk1; Belongs to the protein kinase superfamily. (408 aa)
	HCAG_04248	Uncharacterized protein. (565 aa)
	HCAG_04304	Activator 1 37 kDa subunit. (231 aa)
	HCAG_04835	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
	HCAG_04889	XPA_C domain-containing protein. (359 aa)
	HCAG_04902	Activator 1 subunit 3. (366 aa)
	HCAG_04928	Uncharacterized protein. (218 aa)
	HCAG_05418	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (821 aa)
	HCAG_06498	DNA polymerase. (1086 aa)
	HCAG_06512	Uncharacterized protein. (459 aa)
	HCAG_06583	DNA ligase. (1046 aa)
	HCAG_06715	DNA repair helicase RAD3. (683 aa)
	HCAG_06861	Activator 1 37 kDa subunit. (354 aa)
	HCAG_06934	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (506 aa)
	HCAG_05775	Uncharacterized protein. (1056 aa)
	HCAG_07073	RING-type domain-containing protein. (379 aa)
	HCAG_07177	Uncharacterized protein. (909 aa)
	HCAG_07298	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (790 aa)
	HCAG_07759	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (455 aa)
	HCAG_07869	WD_REPEATS_REGION domain-containing protein. (432 aa)
	HCAG_08702	DNA repair and recombination protein RAD26. (1275 aa)
	HCAG_08910	DNA repair protein Rex1. (72 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00496	HCAG_00846	A6QSZ0	A6QTZ0	Uncharacterized protein.	Uncharacterized protein.	0.999
HCAG_00496	HCAG_01084	A6QSZ0	A6QUM8	Uncharacterized protein.	Uncharacterized protein.	0.610
HCAG_00496	HCAG_01094	A6QSZ0	A6QUN8	Uncharacterized protein.	CPSF_A domain-containing protein.	0.843
HCAG_00496	HCAG_01528	A6QSZ0	A6QVX1	Uncharacterized protein.	Uncharacterized protein.	0.999
HCAG_00496	HCAG_02026	A6QSZ0	A6QXB9	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.669
HCAG_00496	HCAG_02903	A6QSZ0	A6QZU6	Uncharacterized protein.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.989
HCAG_00496	HCAG_03036	A6QSZ0	A6R079	Uncharacterized protein.	Zf-rbx1 domain-containing protein.	0.627
HCAG_00496	HCAG_03230	A6QSZ0	A6R0S3	Uncharacterized protein.	ERCC4 domain-containing protein.	0.868
HCAG_00496	HCAG_03337	A6QSZ0	A6R130	Uncharacterized protein.	Uncharacterized protein.	0.976
HCAG_00496	HCAG_03825	A6QSZ0	A6R2G7	Uncharacterized protein.	Activator 1 38 kDa subunit.	0.542
HCAG_00496	HCAG_04046	A6QSZ0	A6R338	Uncharacterized protein.	Serine/threonine-protein kinase crk1; Belongs to the protein kinase superfamily.	0.978
HCAG_00496	HCAG_04304	A6QSZ0	A6R3U6	Uncharacterized protein.	Activator 1 37 kDa subunit.	0.524
HCAG_00496	HCAG_04889	A6QSZ0	A6R5I1	Uncharacterized protein.	XPA_C domain-containing protein.	0.963
HCAG_00496	HCAG_04902	A6QSZ0	A6R5J4	Uncharacterized protein.	Activator 1 subunit 3.	0.524
HCAG_00496	HCAG_05775	A6QSZ0	A6R9Y7	Uncharacterized protein.	Uncharacterized protein.	0.879
HCAG_00496	HCAG_06583	A6QSZ0	A6R8E2	Uncharacterized protein.	DNA ligase.	0.624
HCAG_00496	HCAG_06715	A6QSZ0	A6R8S4	Uncharacterized protein.	DNA repair helicase RAD3.	0.999
HCAG_00496	HCAG_06861	A6QSZ0	A6R970	Uncharacterized protein.	Activator 1 37 kDa subunit.	0.524
HCAG_00496	HCAG_06934	A6QSZ0	A6R9E3	Uncharacterized protein.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.998
HCAG_00496	HCAG_07073	A6QSZ0	A6RBR5	Uncharacterized protein.	RING-type domain-containing protein.	0.997