(56 nodes) MAPK signaling pathway - yeast network (Histoplasma capsulatum NAm1)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCAG_00050	BZIP domain-containing protein. (511 aa)
	HCAG_00181	Protein kinase domain-containing protein. (343 aa)
	SHO1	High osmolarity signaling protein SHO1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (292 aa)
	HCAG_00732	Uncharacterized protein. (563 aa)
	HCAG_00777	Uncharacterized protein. (1158 aa)
	HCAG_00842	Uncharacterized protein. (751 aa)
	HCAG_01053	Uncharacterized protein. (187 aa)
	HCAG_01152	Uncharacterized protein. (357 aa)
	HCAG_01271	PIPK domain-containing protein. (781 aa)
	HCAG_01478	Uncharacterized protein. (246 aa)
	HCAG_01561	Uncharacterized protein. (929 aa)
	HCAG_01783	Protein kinase domain-containing protein. (1381 aa)
	HCAG_02220	Protein kinase domain-containing protein. (668 aa)
	HCAG_02453	Uncharacterized protein. (435 aa)
	HCAG_02483	PPM-type phosphatase domain-containing protein. (629 aa)
	HCAG_02608	Guanine nucleotide-binding protein beta subunit. (287 aa)
	HCAG_02974	Uncharacterized protein. (360 aa)
	HCAG_03019	Non-specific serine/threonine protein kinase. (881 aa)
	HCAG_03182	Protein kinase domain-containing protein. (1212 aa)
	HCAG_03207	MADS-box domain-containing protein. (239 aa)
	HCAG_03260	Protein kinase domain-containing protein. (298 aa)
	HCAG_03267	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (427 aa)
	HCAG_03461	Protein kinase byr1. (541 aa)
	HCAG_03570	G protein gamma domain-containing protein. (72 aa)
	HCAG_03931	TPR_REGION domain-containing protein. (978 aa)
	HCAG_04050	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1959 aa)
	HCAG_04173	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (307 aa)
	HCAG_04527	14-3-3 family protein ArtA; Belongs to the 14-3-3 family. (268 aa)
	HCAG_05109	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (749 aa)
	HCAG_05236	Protein kinase domain-containing protein. (369 aa)
	HCAG_05250	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	HCAG_05289	1,3-beta-glucan synthase component GLS1. (1901 aa)
	HCAG_05313	WSC domain-containing protein. (277 aa)
	HCAG_05557	Casein kinase I isoform gamma-1. (406 aa)
	HCAG_05560	Uncharacterized protein. (192 aa)
	HCAG_06643	Protein kinase domain-containing protein. (825 aa)
	HCAG_06848	Cytokinesis protein sepA. (1670 aa)
	HCAG_06889	Transcriptional repressor TUP1. (568 aa)
	HCAG_05876	Cell division control protein 2; Belongs to the protein kinase superfamily. (324 aa)
	HCAG_05898	M-phase inducer phosphatase. (456 aa)
	HCAG_06099	HPt domain-containing protein. (106 aa)
	HCAG_06159	E3 ubiquitin-protein ligase. (883 aa)
	HCAG_06305	Uncharacterized protein. (701 aa)
	HCAG_07204	Rho-GAP domain-containing protein. (556 aa)
	HCAG_07578	Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (728 aa)
	HCAG_07675	Uncharacterized protein. (912 aa)
	HCAG_07838	Uncharacterized protein. (685 aa)
	HCAG_08014	Uncharacterized protein. (610 aa)
	HCAG_08064	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (503 aa)
	HCAG_08069	Uncharacterized protein. (544 aa)
	HCAG_08451	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	HCAG_08552	Transcription factor steA. (556 aa)
	HCAG_08908	Opy2 domain-containing protein. (428 aa)
	HCAG_09016	Non-specific serine/threonine protein kinase. (904 aa)
	HCAG_09047	Uncharacterized protein. (898 aa)
	HCAG_09343	CNH domain-containing protein. (175 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00050	HCAG_03260	A6QRP4	A6R0V3	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.970
HCAG_00050	HCAG_03931	A6QRP4	A6R2S3	BZIP domain-containing protein.	TPR_REGION domain-containing protein.	0.941
HCAG_00050	HCAG_05236	A6QRP4	A6R6H8	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.970
HCAG_00050	HCAG_05250	A6QRP4	A6R6J2	BZIP domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.632
HCAG_00050	HCAG_06889	A6QRP4	A6R998	BZIP domain-containing protein.	Transcriptional repressor TUP1.	0.946
HCAG_00050	HCAG_08451	A6QRP4	A6RFN5	BZIP domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.974
HCAG_00181	HCAG_01783	A6QS25	A6QWM6	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.641
HCAG_00181	HCAG_03260	A6QS25	A6R0V3	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.611
HCAG_00181	HCAG_04173	A6QS25	A6R3G5	Protein kinase domain-containing protein.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.555
HCAG_00181	HCAG_04527	A6QS25	A6R4G9	Protein kinase domain-containing protein.	14-3-3 family protein ArtA; Belongs to the 14-3-3 family.	0.555
HCAG_00181	HCAG_05236	A6QS25	A6R6H8	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.611
HCAG_00181	HCAG_05250	A6QS25	A6R6J2	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.600
HCAG_00181	HCAG_05313	A6QS25	A6R6Q5	Protein kinase domain-containing protein.	WSC domain-containing protein.	0.523
HCAG_00181	HCAG_05560	A6QS25	A6R7F2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.654
HCAG_00181	HCAG_05876	A6QS25	A6RA88	Protein kinase domain-containing protein.	Cell division control protein 2; Belongs to the protein kinase superfamily.	0.423
HCAG_00181	HCAG_08451	A6QS25	A6RFN5	Protein kinase domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.611
HCAG_00181	HCAG_09047	A6QS25	A6RHD0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.779
HCAG_00181	SHO1	A6QS25	A6QTM4	Protein kinase domain-containing protein.	High osmolarity signaling protein SHO1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	0.559
HCAG_00732	HCAG_01783	A6QTM6	A6QWM6	Uncharacterized protein.	Protein kinase domain-containing protein.	0.994
HCAG_00732	HCAG_02220	A6QTM6	A6QXW3	Uncharacterized protein.	Protein kinase domain-containing protein.	0.692