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Pars_0063 Pars_0063 Pars_0138 Pars_0138 Pars_0139 Pars_0139 Pars_0193 Pars_0193 Pars_0194 Pars_0194 Pars_0195 Pars_0195 Pars_0196 Pars_0196 Pars_0489 Pars_0489 Pars_0509 Pars_0509 Pars_0887 Pars_0887 acsA acsA Pars_1035 Pars_1035 Pars_1187 Pars_1187 Pars_1188 Pars_1188 Pars_1189 Pars_1189 Pars_1205 Pars_1205 Pars_1249 Pars_1249 Pars_1250 Pars_1250 Pars_1308 Pars_1308 Pars_1533 Pars_1533 Pars_1705 Pars_1705 Pars_1706 Pars_1706 Pars_1707 Pars_1707 Pars_1708 Pars_1708 ilvE ilvE ilvC ilvC Pars_1723 Pars_1723 Pars_1724 Pars_1724 Pars_1804 Pars_1804 Pars_1805 Pars_1805 leuC leuC Pars_2059 Pars_2059 leuD leuD Pars_2063 Pars_2063 Pars_2064 Pars_2064 Pars_2097 Pars_2097 Pars_2267 Pars_2267 ilvD ilvD Pars_2277 Pars_2277 Pars_2278 Pars_2278 Pars_2279 Pars_2279
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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Your Input:
Pars_0063PFAM: pyruvate kinase; KEGG: pai:PAE0819 pyruvate kinase; Belongs to the pyruvate kinase family. (449 aa)
Pars_0138TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pis:Pisl_1174 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit. (314 aa)
Pars_0139PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE0939 2-oxoacid ferredoxin oxidoreductase alpha subunit. (633 aa)
Pars_0193KEGG: pai:PAE1040 pyruvate ferredoxin oxidoreductase gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (175 aa)
Pars_0194TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pis:Pisl_1231 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (102 aa)
Pars_0195Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE1042 pyruvate ferredoxin oxidoreductase alpha subunit. (393 aa)
Pars_0196Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE1043 pyruvate ferredoxin oxidoreductase beta subunit. (314 aa)
Pars_0489PFAM: malate synthase; KEGG: pai:PAE1287 malate synthase. (813 aa)
Pars_0509PFAM: aldehyde dehydrogenase; KEGG: sto:ST1116 methylmalonate-semialdehyde dehydrogenase. (491 aa)
Pars_0887Propionate CoA-transferase; PFAM: coenzyme A transferase; KEGG: pai:PAE2827 coA transferase, putative. (543 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
Pars_1035KEGG: pai:PAE3584 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase. (375 aa)
Pars_1187PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: pai:PAE2648 pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (408 aa)
Pars_1188PFAM: Transketolase, central region; Transketolase domain protein; KEGG: pai:PAE2646 pyruvate dehydrogenase E1 beta subunit. (322 aa)
Pars_1189PFAM: dehydrogenase, E1 component; KEGG: pai:PAE2644 pyruvate dehydrogenase E1 alpha subunit. (370 aa)
Pars_1205TIGRFAM: mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: pai:PAE2623 mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (464 aa)
Pars_1249TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE1558 2-oxoacid ferredoxin oxidoreductase beta subunit. (298 aa)
Pars_1250PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE1559 2-oxoacid ferredoxin oxidoreductase alpha subunit. (546 aa)
Pars_1308PFAM: AMP-dependent synthetase and ligase; KEGG: pis:Pisl_0218 AMP-dependent synthetase and ligase. (633 aa)
Pars_1533L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pis:Pisl_1029 threonine dehydratase. (402 aa)
Pars_1705PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE3274 2-ketoacid ferredoxin oxidoreductase beta subunit. (299 aa)
Pars_1706PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE3275 2-ketoacid ferredoxin oxidoreductase alpha subunit. (384 aa)
Pars_1707TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE3276 2-ketoacid ferredoxin oxidoreductase delta subunit. (82 aa)
Pars_1708TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pai:PAE3279 2-ketoacid ferredoxin oxidoreductase gamma subunit. (182 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (303 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
Pars_1723KEGG: pai:PAE3299 acetolactate synthase small subunit. (76 aa)
Pars_1724TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. (548 aa)
Pars_1804PFAM: CoA-binding domain protein; KEGG: pai:PAE3250 hypothetical protein. (461 aa)
Pars_1805KEGG: pai:PAE3249 hypothetical protein. (233 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa)
Pars_2059TIGRFAM: homocitrate synthase; PFAM: regulatory protein, AsnC/Lrp family; pyruvate carboxyltransferase; KEGG: pis:Pisl_1808 homocitrate synthase. (489 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
Pars_20632-isopropylmalate synthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; PFAM: pyruvate carboxyltransferase; KEGG: pis:Pisl_1814 isopropylmalate/citramalate/homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa)
Pars_2064PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pis:Pisl_1815 3-isopropylmalate dehydrogenase. (325 aa)
Pars_2097TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pis:Pisl_1355 2-isopropylmalate synthase/homocitrate synthase family protein. (496 aa)
Pars_2267Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF1780 acetolactate synthase large subunit. (549 aa)
ilvDKEGG: pai:PAE0615 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (564 aa)
Pars_2277PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pis:Pisl_0326 thiamine pyrophosphate enzyme domain protein TPP-binding. (333 aa)
Pars_2278PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: pis:Pisl_0325 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (402 aa)
Pars_2279TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pis:Pisl_0324 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (312 aa)
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
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