STRINGSTRING
Pars_0063 Pars_0063 Pars_0109 Pars_0109 Pars_0138 Pars_0138 Pars_0139 Pars_0139 Pars_0193 Pars_0193 Pars_0194 Pars_0194 Pars_0195 Pars_0195 Pars_0196 Pars_0196 acyP acyP Pars_0309 Pars_0309 Pars_0457 Pars_0457 Pars_0489 Pars_0489 Pars_0510 Pars_0510 Pars_0511 Pars_0511 Pars_0515 Pars_0515 Pars_0558 Pars_0558 Pars_0673 Pars_0673 Pars_0795 Pars_0795 Pars_0827 Pars_0827 Pars_0828 Pars_0828 Pars_0887 Pars_0887 acsA acsA Pars_1008 Pars_1008 ppcA ppcA Pars_1187 Pars_1187 Pars_1188 Pars_1188 Pars_1189 Pars_1189 Pars_1249 Pars_1249 Pars_1250 Pars_1250 Pars_1308 Pars_1308 Pars_1445 Pars_1445 Pars_1571 Pars_1571 Pars_1705 Pars_1705 Pars_1706 Pars_1706 Pars_1707 Pars_1707 Pars_1708 Pars_1708 Pars_1804 Pars_1804 Pars_1805 Pars_1805 Pars_2059 Pars_2059 Pars_2063 Pars_2063 Pars_2097 Pars_2097 Pars_2233 Pars_2233 Pars_2277 Pars_2277 Pars_2278 Pars_2278 Pars_2279 Pars_2279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pars_0063PFAM: pyruvate kinase; KEGG: pai:PAE0819 pyruvate kinase; Belongs to the pyruvate kinase family. (449 aa)
Pars_0109KEGG: pai:PAE0890 hypothetical protein; Belongs to the acylphosphatase family. (92 aa)
Pars_0138TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pis:Pisl_1174 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit. (314 aa)
Pars_0139PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE0939 2-oxoacid ferredoxin oxidoreductase alpha subunit. (633 aa)
Pars_0193KEGG: pai:PAE1040 pyruvate ferredoxin oxidoreductase gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (175 aa)
Pars_0194TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pis:Pisl_1231 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (102 aa)
Pars_0195Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE1042 pyruvate ferredoxin oxidoreductase alpha subunit. (393 aa)
Pars_0196Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE1043 pyruvate ferredoxin oxidoreductase beta subunit. (314 aa)
acyPPFAM: acylphosphatase; KEGG: pai:PAE1232 acylphosphatase, putative. (95 aa)
Pars_0309KEGG: pai:PAE1220 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase. (407 aa)
Pars_0457PFAM: Thiolase; KEGG: pis:Pisl_1437 thiolase. (391 aa)
Pars_0489PFAM: malate synthase; KEGG: pai:PAE1287 malate synthase. (813 aa)
Pars_0510Pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; KEGG: pis:Pisl_1888 phosphoenolpyruvate synthase. (334 aa)
Pars_0511PFAM: PEP-utilising enzyme, mobile region; KEGG: gme:Gmet_2100 hypothetical protein. (594 aa)
Pars_0515PFAM: PEP-utilising enzyme, mobile region; KEGG: rxy:Rxyl_1575 PEP-utilising enzyme, mobile region. (546 aa)
Pars_0558Fumarase; PFAM: fumarate lyase; KEGG: pai:PAE2743 fumarate hydratase class II. (437 aa)
Pars_0673PFAM: beta-lactamase domain protein; KEGG: pai:PAE1540 conserved protein (possibly metallo-beta-lactamase superfamily). (206 aa)
Pars_0795KEGG: pai:PAE2183 acetyl-CoA C-acyltransferase. (369 aa)
Pars_0827Fumarase alpha subunit; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; KEGG: pis:Pisl_0950 hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit. (289 aa)
Pars_0828Fumarase beta subunit; KEGG: pai:PAE2131 fumarate hydratase class I beta subunit; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region. (201 aa)
Pars_0887Propionate CoA-transferase; PFAM: coenzyme A transferase; KEGG: pai:PAE2827 coA transferase, putative. (543 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
Pars_1008KEGG: pai:PAE3383 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing enzyme; pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region. (916 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (460 aa)
Pars_1187PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: pai:PAE2648 pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase). (408 aa)
Pars_1188PFAM: Transketolase, central region; Transketolase domain protein; KEGG: pai:PAE2646 pyruvate dehydrogenase E1 beta subunit. (322 aa)
Pars_1189PFAM: dehydrogenase, E1 component; KEGG: pai:PAE2644 pyruvate dehydrogenase E1 alpha subunit. (370 aa)
Pars_1249TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE1558 2-oxoacid ferredoxin oxidoreductase beta subunit. (298 aa)
Pars_1250PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE1559 2-oxoacid ferredoxin oxidoreductase alpha subunit. (546 aa)
Pars_1308PFAM: AMP-dependent synthetase and ligase; KEGG: pis:Pisl_0218 AMP-dependent synthetase and ligase. (633 aa)
Pars_1445Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa)
Pars_1571PFAM: Lactate/malate dehydrogenase; KEGG: pai:PAE2370 malate dehydrogenase; Belongs to the LDH/MDH superfamily. (309 aa)
Pars_1705PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pai:PAE3274 2-ketoacid ferredoxin oxidoreductase beta subunit. (299 aa)
Pars_1706PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE3275 2-ketoacid ferredoxin oxidoreductase alpha subunit. (384 aa)
Pars_1707TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE3276 2-ketoacid ferredoxin oxidoreductase delta subunit. (82 aa)
Pars_1708TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pai:PAE3279 2-ketoacid ferredoxin oxidoreductase gamma subunit. (182 aa)
Pars_1804PFAM: CoA-binding domain protein; KEGG: pai:PAE3250 hypothetical protein. (461 aa)
Pars_1805KEGG: pai:PAE3249 hypothetical protein. (233 aa)
Pars_2059TIGRFAM: homocitrate synthase; PFAM: regulatory protein, AsnC/Lrp family; pyruvate carboxyltransferase; KEGG: pis:Pisl_1808 homocitrate synthase. (489 aa)
Pars_20632-isopropylmalate synthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; PFAM: pyruvate carboxyltransferase; KEGG: pis:Pisl_1814 isopropylmalate/citramalate/homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa)
Pars_2097TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pis:Pisl_1355 2-isopropylmalate synthase/homocitrate synthase family protein. (496 aa)
Pars_2233Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: pai:PAE1688 malate oxidoreductase (mae). (434 aa)
Pars_2277PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: pis:Pisl_0326 thiamine pyrophosphate enzyme domain protein TPP-binding. (333 aa)
Pars_2278PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: pis:Pisl_0325 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (402 aa)
Pars_2279TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pis:Pisl_0324 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (312 aa)
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.