STRINGSTRING
Patl_0244 Patl_0244 gppA gppA Patl_4064 Patl_4064 surE surE rppH rppH dgt dgt Patl_3706 Patl_3706 Patl_3565 Patl_3565 Patl_3400 Patl_3400 Patl_3323 Patl_3323 Patl_3287 Patl_3287 xseA xseA csrA csrA Patl_2748 Patl_2748 Patl_2721 Patl_2721 Patl_2630 Patl_2630 Patl_2438 Patl_2438 rnhA rnhA Patl_2335 Patl_2335 Patl_2330 Patl_2330 rhlE rhlE rne rne Patl_2015 Patl_2015 pnp pnp Patl_1379 Patl_1379 Patl_1343 Patl_1343 xseB xseB rnhB rnhB Patl_0790 Patl_0790 Patl_0588 Patl_0588 Patl_0549 Patl_0549 mtnN mtnN deaD deaD Patl_0338 Patl_0338 Patl_0246 Patl_0246 Patl_0221 Patl_0221 Patl_4283 Patl_4283 rph rph rhlB rhlB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Patl_0244PFAM: S1/P1 nuclease; KEGG: pha:PSHAb0342 putative S1/P1 nuclease. (256 aa)
gppAPpx/GppA phosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (503 aa)
Patl_4064Hypothetical protein. (392 aa)
surE5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (248 aa)
rppHNUDIX hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (174 aa)
dgtPutative deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. (482 aa)
Patl_3706TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: hch:HCH_01808 predicted pyrophosphatase. (284 aa)
Patl_3565PFAM: 5'-Nucleotidase-like; KEGG: mag:amb3606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Belongs to the 5'-nucleotidase family. (491 aa)
Patl_3400PFAM: ribonuclease H; KEGG: pca:Pcar_2273 hypothetical protein. (163 aa)
Patl_3323PFAM: Ppx/GppA phosphatase; KEGG: vvy:VV0726 exopolyphosphatase; Belongs to the GppA/Ppx family. (509 aa)
Patl_3287Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (208 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (444 aa)
csrACarbon storage regulator, CsrA / carbon storage regulator, CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by s [...] (71 aa)
Patl_2748KEGG: ade:Adeh_2330 hypothetical protein. (280 aa)
Patl_2721TIGRFAM: addiction module toxin, Txe/YoeB family; PFAM: Addiction module toxin, Txe/YoeB; KEGG: ilo:IL0286 RelE-like protein. (62 aa)
Patl_2630KEGG: pca:Pcar_0528 hypothetical protein. (96 aa)
Patl_2438PFAM: helicase-like DEAD/DEAH box helicase-like; KEGG: dps:DP1413 similar to ATP-dependent RNA helicase. (458 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (153 aa)
Patl_2335PFAM: metal-dependent phosphohydrolase, HD subdomain; KEGG: pha:PSHAa1148 two-component regulator with metal-dependent phosphohydrolase, HD region. (212 aa)
Patl_2330PFAM: helicase-like DEAD/DEAH box helicase-like; KEGG: son:SO1383 ATP-dependent RNA helicase, DEAD box family; Belongs to the DEAD box helicase family. (426 aa)
rhlEDEAD/DEAH box helicase-like protein; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (435 aa)
rneRNAse E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1070 aa)
Patl_2015KEGG: vpa:VP0925 deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: putative deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD region; Belongs to the dGTPase family. Type 2 subfamily. (467 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (703 aa)
Patl_1379KEGG: cps:CPS_1758 putative alkaline phosphatase. (622 aa)
Patl_1343KEGG: pha:PSHAb0433 hypothetical protein. (301 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (83 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (197 aa)
Patl_0790Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
Patl_0588PFAM: helicase-like DbpA, RNA-binding DEAD/DEAH box helicase-like; KEGG: ypm:YP1617 ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (459 aa)
Patl_0549Methylthioadenosine nucleosidase; PFAM: purine and other phosphorylases, family 1; KEGG: ccr:CC2266 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. (329 aa)
mtnNMethylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (235 aa)
deaDATP-dependent RNA helicase CsdA; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (579 aa)
Patl_0338PFAM: cyclic-AMP phosphodiesterase, class-II; KEGG: vfi:VF1256 3',5'-cyclic-nucleotide phosphodiesterase. (339 aa)
Patl_0246PFAM: NUDIX hydrolase; KEGG: ilo:IL2307 NUDIX family pyrophosphohydrolases containing a Zn-finger. (271 aa)
Patl_0221KEGG: pha:PSHAb0433 hypothetical protein. (361 aa)
Patl_4283TIGRFAM: conserved hypothetical protein; PFAM: YicC-like-like Domain of unknown function DUF1732; KEGG: cps:CPS_0107 conserved hypothetical protein TIGR00255. (290 aa)
rphRNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (237 aa)
rhlBDEAD/DEAH box helicase-like protein; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
Your Current Organism:
Pseudoalteromonas atlantica
NCBI taxonomy Id: 342610
Other names: P. atlantica T6c, Pseudoalteromonas atlantica T6c, Pseudoalteromonas atlantica str. T6c, Pseudoalteromonas atlantica strain T6c
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