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ACD06459.1 ACD06459.1 phoB phoB phoR phoR ACD09849.1 ACD09849.1 fimZ fimZ rcsC rcsC rcsB rcsB yojN yojN narP narP ACD06515.1 ACD06515.1 ACD08710.1 ACD08710.1 ACD09349.1 ACD09349.1 uvrY uvrY sdiA sdiA ACD08150.1 ACD08150.1 ACD06769.1 ACD06769.1 fliD fliD fliS fliS fliM fliM fliN fliN fliO fliO fliP fliP fliQ fliQ fliR fliR rcsA rcsA ACD09783.1 ACD09783.1 ACD07120.1 ACD07120.1 ACD08558.1 ACD08558.1 phoQ phoQ phoP phoP ycgR ycgR ACD08502.1 ACD08502.1 ACD08843.1 ACD08843.1 ACD09607.1 ACD09607.1 dos dos rstA rstA rstB rstB ACD07494.1 ACD07494.1 ACD09147.1 ACD09147.1 flhE flhE cheZ cheZ cheY cheY cheB cheB cheR cheR tap tap cheM cheM cheW cheW cheA cheA flgL flgL flgK flgK flgH flgH flgF flgF flgE flgE flgD flgD flgC flgC flgB flgB flgA flgA flgM flgM flgN flgN torR torR torS torS ACD08968.1 ACD08968.1 evgA evgA evgS evgS ACD08467.1 ACD08467.1 narQ narQ ACD08152.1 ACD08152.1 barA barA ACD07601.1 ACD07601.1 aer aer arcB arcB envZ envZ ompR ompR ACD09101.1 ACD09101.1 ACD08920.1 ACD08920.1 ACD08358.1 ACD08358.1 cpxA cpxA cpxR cpxR tsr tsr ACD08218.1 ACD08218.1 creB creB creC creC ACD08316.1 ACD08316.1 arcA arcA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACD06459.1MASE2 domain/diguanylate cyclase; Identified by match to protein family HMM PF00990; match to protein family HMM PF05230; match to protein family HMM TIGR00254. (366 aa)
phoBPhosphate regulon transcriptional regulatory protein PhoB; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486; match to protein family HMM TIGR02154. (229 aa)
phoRPhosphate regulon sensor protein PhoR; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; match to protein family HMM TIGR02966. (431 aa)
ACD09849.1Cyclic diguanylate phosphodiesterase (EAL) domain protein; Identified by match to protein family HMM PF00563. (498 aa)
fimZFimbriae Z protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00196. (199 aa)
rcsCSensor histidine kinase/response regulator RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (949 aa)
rcsBCapsular synthesis regulator component B; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (228 aa)
yojNSensor histidine kinase YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (886 aa)
narPNitrate/nitrite response regulator NarP; Identified by similarity to SP:P31802; match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281. (215 aa)
ACD06515.1Putative cyclic diguanylate phosphodiesterase; Identified by match to protein family HMM PF00563. (518 aa)
ACD08710.1Heavy metal response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486; match to protein family HMM TIGR01387. (260 aa)
ACD09349.1Heavy metal sensor histidine kinase; Member of a two-component regulatory system. (452 aa)
uvrYResponse regulator UvrY; Identified by match to protein family HMM PF00072; match to protein family HMM PF00196. (218 aa)
sdiARegulatory protein SdiA; Identified by match to protein family HMM PF00196; match to protein family HMM PF03472. (240 aa)
ACD08150.1FliZ protein; Identified by match to protein family HMM PF02899. (183 aa)
ACD06769.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (568 aa)
fliDFlagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (468 aa)
fliSFlagellar protein FliS; Identified by similarity to SP:P26608; match to protein family HMM PF02561; match to protein family HMM TIGR00208. (136 aa)
fliMFlagellar motor switch protein FliM; Identified by similarity to SP:P06974. (122 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliOFlagellar protein FliO; Identified by similarity to SP:P22586; match to protein family HMM PF04347; match to protein family HMM TIGR03500. (121 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRFlagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
rcsAColanic acid capsular biosynthesis activation protein A; Identified by match to protein family HMM PF00196. (203 aa)
ACD09783.1Diguanylate cyclase (GGDEF) domain protein; Identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254. (558 aa)
ACD07120.1Sensory box-containing diguanylate cyclase; Identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM PF05231; match to protein family HMM PF08447; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254. (1105 aa)
ACD08558.1Identified by match to protein family HMM PF08007. (373 aa)
phoQSensor histidine kinase PhoQ; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08918. (486 aa)
phoPDNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (223 aa)
ycgRPutative type IV pilus assembly protein PilZ; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (244 aa)
ACD08502.1Sensory box-containing diguanylate cyclase/cyclic diguanylate phosphodiesterase; Identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254. (661 aa)
ACD08843.1Sensory box-containing diguanylate cyclase; Identified by match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254. (430 aa)
ACD09607.1Putative ggdef domain; Identified by match to protein family HMM PF00990. (128 aa)
dosHeme-regulated cyclic AMP phosphodiesterase; Identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254. (807 aa)
rstATranscriptional regulatory protein RstA; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (242 aa)
rstBSensor histidine kinase RstB; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (433 aa)
ACD07494.1Diguanylate cyclase (GGDEF) domain protein; Identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254. (491 aa)
ACD09147.1Ggdef domain protein; Identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254. (198 aa)
flhEFlagellar protein FlhE; Identified by similarity to SP:P76297; match to protein family HMM PF06366. (130 aa)
cheZChemotaxis phosphatase CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (214 aa)
cheYChemotaxis protein CheY; Identified by match to protein family HMM PF00072. (129 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheRChemotaxis protein methyltransferase CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (286 aa)
tapMethyl-accepting chemotaxis protein IV; Identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203. (533 aa)
cheMMethyl-accepting chemotaxis protein II; Identified by match to protein family HMM PF00015; match to protein family HMM PF02203. (472 aa)
cheWChemotaxis adaptor protein CheW; Identified by match to protein family HMM PF01584. (167 aa)
cheAChemotaxis protein CheA; Identified by similarity to SP:P07363; match to protein family HMM PF01584; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF02895; match to protein family HMM PF09078. (654 aa)
flgLFlagellar hook-associated protein 3; Identified by match to protein family HMM PF00669; match to protein family HMM TIGR02550. (317 aa)
flgKFlagellar hook-associated protein FlgK; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02492. (547 aa)
flgHFlagellar L-ring protein FlgH; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgFFlagellar basal-body rod protein FlgF; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02490; match to protein family HMM TIGR03506. (251 aa)
flgEFlagellar hook protein FlgE; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM PF07559; match to protein family HMM TIGR03506. (402 aa)
flgDFlagellar hook capping protein FlgD; Required for flagellar hook formation. May act as a scaffolding protein. (231 aa)
flgCFlagellar basal-body rod protein FlgC; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR01395; Belongs to the flagella basal body rod proteins family. (134 aa)
flgBFlagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
flgAFlagella basal body P-ring formation protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgMNegative regulator of flagellin synthesis FlgM; Identified by similarity to SP:P43532; match to protein family HMM PF04316. (113 aa)
flgNFlagella synthesis protein FlgN; Identified by match to protein family HMM PF05130. (138 aa)
torRtorCAD operon transcriptional regulatory protein TorR; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (230 aa)
torSSensor histidine kinase/response regulator TorS; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR02956. (914 aa)
ACD08968.1Putative cyclic diguanylate phosphodiesterase (EAL) domain; Identified by match to protein family HMM PF00563. (181 aa)
evgAPositive transcription regulator EvgA; Identified by similarity to SP:P30854; match to protein family HMM PF00072; match to protein family HMM PF00196. (204 aa)
evgSSensor histidine kinase/response regulator EvgS; Identified by similarity to SP:P30855; match to protein family HMM PF00072; match to protein family HMM PF00497; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518. (1197 aa)
ACD08467.1Diguanylate cyclase. (186 aa)
narQNitrate/nitrite sensor histidine kinase NarQ; Identified by similarity to SP:P27896; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730. (566 aa)
ACD08152.1Diguanylate cyclase (GGDEF) domain protein, truncated; Identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254. (139 aa)
barASensor histidine kinase/response regulator BarA; Identified by similarity to SP:P0AEC5; match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF01627; match to protein family HMM PF02518. (918 aa)
ACD07601.1Cyclic diguanylate phosphodiesterase (EAL) domain; Identified by similarity to SP:P13518; match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM TIGR00254. (646 aa)
aerAerotaxis receptor; Identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF08447; match to protein family HMM TIGR00229. (506 aa)
arcBAerobic respiration control sensor protein ArcB; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. (778 aa)
envZOsmolarity sensor protein EnvZ; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (450 aa)
ompRTranscriptional regulatory protein OmpR; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (239 aa)
ACD09101.1Transcriptional regulator, LuxR family; Identified by match to protein family HMM PF00196; match to protein family HMM PF08281. (200 aa)
ACD08920.1Cyclic diguanylate phosphodiesterase; Identified by match to protein family HMM PF00563. (255 aa)
ACD08358.1Putative diguanylate cyclase; Identified by match to protein family HMM PF00563; match to protein family HMM PF00672; match to protein family HMM PF00990; match to protein family HMM TIGR00254. (651 aa)
cpxASensor histidine kinase CpxA; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (457 aa)
cpxRTranscriptional regulatory protein CpxR; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (232 aa)
tsrIdentified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203. (551 aa)
ACD08218.1creA protein; Identified by match to protein family HMM PF05981. (157 aa)
creBTranscriptional regulatory protein CreB; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (221 aa)
creCSensor protein CreC; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (474 aa)
ACD08316.1Inner membrane protein CreD; Identified by match to protein family HMM PF06123. (450 aa)
arcAAerobic respiration control protein ArcA; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (238 aa)
Your Current Organism:
Shigella boydii
NCBI taxonomy Id: 344609
Other names: S. boydii CDC 3083-94, Shigella boydii BS512, Shigella boydii CDC 3083-94, Shigella boydii str. CDC 3083-94, Shigella boydii strain CDC 3083-94
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