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| | carA | Carbamoyl-phosphate synthase, small subunit; Identified by match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family. (382 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Identified by match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family. (1073 aa) |
| | guaC | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | ppnP | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | gsk | Inosine kinase; Identified by match to protein family HMM PF00294. (434 aa) |
| | ushA | UDP-sugar hydrolase/5'-nucleotidase; Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. (550 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | psuG | Indigoidine synthase A like protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (312 aa) |
| | ACD07679.1 | Pyrimidine-specific ribonucleoside hydrolase RihB; Identified by match to protein family HMM PF01156; Belongs to the IUNH family. (242 aa) |
| | ACD06717.1 | Kinase, pfkB family; Identified by match to protein family HMM PF00294. (362 aa) |
| | ACD09707.1 | Identified by match to protein family HMM PF00037; match to protein family HMM PF01180; match to protein family HMM TIGR01037. (411 aa) |
| | ACD09981.1 | Pyridine nucleotide-disulfide oxidoreductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF07992. (412 aa) |
| | ACD09505.1 | Conserved hypothetical protein. (79 aa) |
| | sanA | Protein SanA; Identified by match to protein family HMM PF02698. (239 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa) |
| | ACD08277.1 | Identified by match to protein family HMM PF04172; match to protein family HMM TIGR00659. (231 aa) |
| | yohJ | Identified by match to protein family HMM PF03788. (132 aa) |
| | amn | AMP nucleosidase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR01717. (382 aa) |
| | udk | Uridine kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00235. (213 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | purB | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM PF08328; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | tdk | Thymidine kinase; Identified by match to protein family HMM PF00265. (205 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | add | Adenosine deaminase; Identified by match to protein family HMM PF00962; match to protein family HMM TIGR01430; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | ACD07308.1 | Conserved hypothetical protein. (76 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta subunit; Identified by match to protein family HMM PF00268. (376 aa) |
| | ACD06781.1 | 2Fe-2S iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00111. (84 aa) |
| | yfbR | 5'-nucleotidase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (237 aa) |
| | hda | DnaA family protein Hda; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. (248 aa) |
| | uraA | Uracil permease; Identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801. (429 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | ACD08131.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF03641. (454 aa) |
| | relA | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | ACD07314.1 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. (263 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | ACD08364.1 | Putative membrane protein; Identified by similarity to SP:P46141. (107 aa) |
| | truD | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (349 aa) |
| | surE | Multifunctional protein SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa) |
| | pcm | protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (208 aa) |
| | nlpD | Lipoprotein NlpD; Identified by match to protein family HMM PF01476; match to protein family HMM PF01551. (363 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | nrdE | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa) |
| | nrdI | nrdI protein; Probably involved in ribonucleotide reductase function. (136 aa) |
| | nrdH | Glutaredoxin; Identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194. (81 aa) |
| | ACD07762.1 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (248 aa) |
| | icc | Protein icc; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa) |
| | crp | Catabolite gene activator; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325. (210 aa) |
| | ACD08124.1 | HAD hydrolase, IA family; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509. (222 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | spoT | Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa) |
| | trmH | tRNA guanosine-2'-O-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (229 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa) |
| | ade | Adenine deaminase; Identified by match to protein family HMM PF01979; match to protein family HMM TIGR01178. (569 aa) |
| | cyaA | Adenylate cyclase, class I; Identified by match to protein family HMM PF01295; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877. (429 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (529 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | ACD08002.1 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Identified by match to protein family HMM PF02872. (219 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | nrdD | Anaerobic ribonucleoside-triphosphate reductase; Identified by match to protein family HMM PF01228; match to protein family HMM PF03477; match to protein family HMM TIGR02487. (712 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | yjjG | 5-nucleotidase YjjG; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254. (225 aa) |
| | deoD | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. (239 aa) |
