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thrA thrA thrB thrB thrC thrC dapB dapB dapD dapD proB proB proA proA proC proC aroL aroL hisIE hisIE hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG trpA trpA trpB trpB trpC trpC trpD trpD trpE trpE pabB pabB ACD10006.1 ACD10006.1 putP putP putA putA aroA aroA serC serC aroC aroC ACD09084.1 ACD09084.1 dapA dapA pheA pheA tyrA tyrA lysA lysA argA argA ACD09527.1 ACD09527.1 serA serA metK metK argR argR argG argG aroE aroE argD argD pabA pabA aroB aroB aroK aroK asd asd dapF dapF metE metE metB metB metL metL metF metF argE argE argC argC argB argB argH argH metA metA ACD10039.1 ACD10039.1 lysC lysC tyrB tyrB argF argF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thrAAspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
thrCThreonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (428 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR00965. (274 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa)
aroLShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa)
hisIEphosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM PF01791; match to protein family HMM TIGR00007. (245 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisBHistidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM PF08645; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa)
hisCHistidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpCTryptophan biosynthesis protein trpCF; Identified by match to protein family HMM PF00218; match to protein family HMM PF00697; Belongs to the TrpC family. (453 aa)
trpDAnthranilate synthase, component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
trpEAnthranilate synthase, component I; Identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00565. (520 aa)
pabBAminodeoxychorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553. (453 aa)
ACD10006.1GAF domain protein; Identified by match to protein family HMM PF01590. (183 aa)
putPSodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
putABifunctional protein PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
ACD09084.1Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. (412 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
pheAP-protein; Identified by similarity to SP:P0A9J8; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM TIGR01797. (386 aa)
tyrAT-protein; Identified by similarity to SP:P07023; match to protein family HMM PF01817; match to protein family HMM PF02153; match to protein family HMM TIGR01799. (373 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
argAAmino-acid N-acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM PF00696; match to protein family HMM TIGR01890; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa)
ACD09527.1D-isomer specific 2-hydroxyacid dehydrogenase family protein; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (281 aa)
serAPhosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (156 aa)
argGArgininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
argDAcetylornithine/succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa)
pabAAminodeoxychorismate synthase, component II; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566. (187 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
metBO-succinylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR02080. (386 aa)
metLAspartokinase/homoserine dehydrogenase II; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF03447; match to protein family HMM TIGR00657; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
metF5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
argEAcetylornithine deacetylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01892; Belongs to the peptidase M20A family. ArgE subfamily. (383 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa)
argHArgininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (457 aa)
metAHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa)
ACD10039.1Methionine synthase; Identified by match to protein family HMM PF02965. (230 aa)
lysCAspartokinase III, lysine-sensitive; Identified by match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (449 aa)
tyrBAromatic-amino-acid transaminase; Identified by match to protein family HMM PF00155. (397 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa)
Your Current Organism:
Shigella boydii
NCBI taxonomy Id: 344609
Other names: S. boydii CDC 3083-94, Shigella boydii BS512, Shigella boydii CDC 3083-94, Shigella boydii str. CDC 3083-94, Shigella boydii strain CDC 3083-94
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