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| | parC | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa) |
| | ACD09152.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | ACD08556.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (376 aa) |
| | ACD10189.1 | IS1 ORF2. (62 aa) |
| | ACD07859.1 | Transposase family; Identified by match to protein family HMM PF01527. (139 aa) |
| | ACD07447.1 | IS1 OrfB; Identified by match to protein family HMM PF03400. (97 aa) |
| | ACD06733.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | polB | DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104. (783 aa) |
| | mutT | 7,8-dihydro-8-oxoguanine-triphosphatase; Identified by match to protein family HMM PF00293; match to protein family HMM TIGR00586; Belongs to the Nudix hydrolase family. (129 aa) |
| | ACD09102.1 | IS911, transposase orfA; Identified by match to protein family HMM PF01527. (100 aa) |
| | dnaE | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1160 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (354 aa) |
| | ACD07109.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ACD06605.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | ACD08399.1 | Transposase family; Identified by match to protein family HMM PF01527. (100 aa) |
| | ACD07836.1 | IS911, transposase orfA; Identified by match to protein family HMM PF01527. (100 aa) |
| | ACD06984.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ACD06977.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD06957.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | ACD06970.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD08080.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | rdgC | Recombination-associated exonuclease RdgC; May be involved in recombination; Belongs to the RdgC family. (303 aa) |
| | ACD07729.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | sbcC | Nuclease SbcCD, C subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily. (1047 aa) |
| | sbcD | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (400 aa) |
| | xseB | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa) |
| | ACD07175.1 | Competence protein ComEA; Identified by match to protein family HMM TIGR00426. (123 aa) |
| | ACD07011.1 | methylated-DNA-[protein]-cysteine S-methyltransferase; Identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589. (129 aa) |
| | dnaX | DNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (643 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa) |
| | ACD06865.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD07822.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | ACD06450.1 | IS1 OrfB; Identified by match to protein family HMM PF03400. (97 aa) |
| | ACD08907.1 | Transposase family; Identified by match to protein family HMM PF01527. (100 aa) |
| | ACD09263.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | holA | DNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144; match to protein family HMM TIGR01128. (343 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | ACD07491.1 | Phage integrase; Identified by match to protein family HMM PF00589. (228 aa) |
| | ACD10341.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | ada | Regulatory protein Ada; Identified by match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589. (354 aa) |
| | alkB | Alkylated DNA repair protein AlkB; Identified by match to protein family HMM PF03171; match to protein family HMM TIGR00568. (216 aa) |
| | ACD08145.1 | Putative single stranded DNA-binding protein; Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. (141 aa) |
| | ACD07960.1 | Prophage integrase; Identified by match to protein family HMM PF00589; Belongs to the 'phage' integrase family. (413 aa) |
| | nfo | Endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa) |
| | ACD09856.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (391 aa) |
| | ACD09720.1 | Transposase family; Identified by match to protein family HMM PF01527. (100 aa) |
| | ACD07421.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | ACD08848.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | hchA | Chaperone protein HchA; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), pre [...] (283 aa) |
| | dcm | DNA-cytosine methyltransferase; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. (472 aa) |
| | vsr | Very short patch repair protein; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (156 aa) |
| | ACD06632.1 | Transposase InsN for insertion sequence element B; Identified by match to protein family HMM PF01527. (83 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | ACD06377.1 | Site-specific recombinase, phage integrase family protein; Identified by match to protein family HMM PF00589; Belongs to the 'phage' integrase family. (420 aa) |
| | ACD06928.1 | IS629 transposase orfB; Identified by match to protein family HMM PF00665. (296 aa) |
| | ACD10488.1 | IS629 transposase orfA; Identified by match to protein family HMM PF01527. (108 aa) |
| | ACD08307.1 | Integrase protein. (147 aa) |
| | ACD09609.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | uvrC | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa) |
| | ACD08150.1 | FliZ protein; Identified by match to protein family HMM PF02899. (183 aa) |
| | ACD08295.1 | IS605 family transposase orfB; Identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766. (402 aa) |
| | ACD07620.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa) |
| | ACD09357.1 | IS1 ORF2. (44 aa) |
| | ACD08001.1 | IS1 transposase; Identified by match to protein family HMM PF03400. (116 aa) |
| | ACD09994.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (391 aa) |
| | alkA | DNA-3-methyladenine glycosylase 2; Identified by match to protein family HMM PF00730; match to protein family HMM PF06029. (282 aa) |
| | sbcB | Identified by match to protein family HMM PF00929; match to protein family HMM PF08411. (475 aa) |
| | ACD09692.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | ACD08327.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (326 aa) |
| | ACD06775.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (391 aa) |
| | ACD10132.1 | IS1203 transposase orfA; Identified by match to protein family HMM PF01527. (108 aa) |
| | ACD09636.1 | IS1203 transposase orfB; Identified by match to protein family HMM PF00665. (296 aa) |
| | ACD06514.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | rusA | Crossover junction endodeoxyribonuclease RusA; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC; Belongs to the rusA family. (124 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | ACD07257.1 | DNA methylase; Identified by match to protein family HMM PF01555; Belongs to the N(4)/N(6)-methyltransferase family. (349 aa) |
| | ACD10423.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | ACD06892.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | umuD | Protein UmuD; Identified by match to protein family HMM PF00717; Belongs to the peptidase S24 family. (139 aa) |
| | ACD09450.1 | IS911, transposase orfA; Identified by match to protein family HMM PF01527. (100 aa) |
| | tdk | Thymidine kinase; Identified by match to protein family HMM PF00265. (205 aa) |
| | ACD07912.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (164 aa) |
| | ACD10484.1 | Site-specific recombinase, phage integrase family; Identified by match to protein family HMM PF00589; match to protein family HMM PF09003; Belongs to the 'phage' integrase family. (376 aa) |
| | rusA-2 | Crossover junction endodeoxyribonuclease RusA; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC; Belongs to the rusA family. (126 aa) |
| | ACD09919.1 | DNA methylase; Identified by match to protein family HMM PF01555; Belongs to the N(4)/N(6)-methyltransferase family. (349 aa) |
| | ACD06857.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (865 aa) |
| | ACD08586.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD07450.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | ogt | methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa) |
| | ACD10276.1 | IS629 transposase orfA; Identified by match to protein family HMM PF01527. (108 aa) |
| | ACD08350.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (220 aa) |
| | ACD09456.1 | IS1203 transposase orfB; Identified by match to protein family HMM PF00665. (296 aa) |
| | ACD07781.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | ACD08181.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD06518.1 | Transposase (IS4 family); Identified by match to protein family HMM PF01609. (542 aa) |
| | parE | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa) |
| | ACD06506.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD08990.1 | Transposase family; Identified by match to protein family HMM PF01527. (87 aa) |
| | ACD07534.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | tus | DNA replication terminus site-binding protein; Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence; Belongs to the Tus family. (309 aa) |
| | ACD10324.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | ACD07693.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (391 aa) |
| | ACD10416.1 | Integrase; Identified by match to protein family HMM PF00589. (375 aa) |
| | ACD06863.1 | IS2 ORF2. (88 aa) |
| | ACD09211.1 | IS629 transposase orfB; Identified by match to protein family HMM PF00665. (296 aa) |
| | ACD08839.1 | IS911, transposase orfB; Identified by match to protein family HMM PF00665. (173 aa) |
| | ACD09258.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ihfA | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa) |
| | ACD09021.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | xth | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. (268 aa) |
| | ACD06870.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD06365.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | topB | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (653 aa) |
| | ACD09631.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | ACD09596.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD06601.1 | ISSd1, transposase orfB; Identified by match to protein family HMM PF00665. (272 aa) |
| | holE | DNA polymerase III, theta subunit; Identified by match to protein family HMM PF06440. (76 aa) |
| | ACD10307.1 | Transposase family; Identified by match to protein family HMM PF01527. (102 aa) |
| | ACD06338.1 | DNA methylase; Identified by match to protein family HMM PF01555; Belongs to the N(4)/N(6)-methyltransferase family. (349 aa) |
| | rusA-3 | Crossover junction endodeoxyribonuclease RusA; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC; Belongs to the rusA family. (129 aa) |
| | ACD08314.1 | Phage N-6-adenine-methyltransferase; Identified by match to protein family HMM PF05869; match to protein family HMM TIGR01712. (217 aa) |
| | ACD09190.1 | DNA methylase; Identified by match to protein family HMM PF01555; Belongs to the N(4)/N(6)-methyltransferase family. (391 aa) |
| | ACD10085.1 | IS2 transposase orfA; Identified by match to protein family HMM PF01527. (121 aa) |
| | ACD09517.1 | IS1 protein InsB; Identified by match to protein family HMM PF03400. (195 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1148 aa) |
| | ACD09446.1 | Hydrolase, TatD family; Identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010. (265 aa) |
| | holB | DNA polymerase III, delta' subunit; Identified by match to protein family HMM PF09115; match to protein family HMM TIGR00678. (334 aa) |
| | ACD08439.1 | Transposase, IS1111 family; Identified by match to protein family HMM PF02371. (339 aa) |
| | ACD08103.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD10525.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD10072.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | uup | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF02463. (635 aa) |
| | ACD08096.1 | Transposase (IS4 family); Identified by match to protein family HMM PF01609. (395 aa) |
| | mukB | Chromosome partition protein MukB; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily. (1486 aa) |
| | mukE | Chromosome partition protein MukE; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. (234 aa) |
| | mukF | Chromosome partition protein MukF; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (440 aa) |
| | ihfB | Integration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa) |
| | ACD08772.1 | IS911, transposase orfB; Identified by match to protein family HMM PF00665. (279 aa) |
| | ACD10168.1 | Putative DNA recombination-associated ATPase RarA; Identified by match to protein family HMM PF00004. (447 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (673 aa) |
| | ACD09015.1 | Transposase family; Identified by match to protein family HMM PF01527. (78 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (875 aa) |
| | ACD09090.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta subunit; Identified by match to protein family HMM PF00268. (376 aa) |
| | ACD08222.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | prmB | Ribosomal large subunit L3 protein glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (310 aa) |
| | ACD06725.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ACD06830.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (391 aa) |
| | ACD08861.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | ACD08186.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | hda | DnaA family protein Hda; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. (248 aa) |
| | xseA | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (456 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. Belongs to the RecO family. (242 aa) |
| | ung | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (229 aa) |
| | ACD08800.1 | IS4 ORF; Identified by match to protein family HMM PF01609. (400 aa) |
| | ACD07798.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | recN | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (553 aa) |
| | mutH | DNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (229 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1122 aa) |
| | recB | Exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1180 aa) |
| | recD | Exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (608 aa) |
| | ACD07574.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | xni | Exodeoxyribonuclease-9; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. (281 aa) |
| | ACD08346.1 | IS911, transposase orfA; Identified by match to protein family HMM PF01527. (100 aa) |
| | cas5e | CRISPR-associated protein Cas5; Identified by match to protein family HMM PF09708; match to protein family HMM TIGR01868. (213 aa) |
| | ACD09633.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (853 aa) |
| | recA | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | holD | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (137 aa) |
| | ACD08257.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | dnaT | Primosomal protein 1; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'. (179 aa) |
| | ACD06691.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | nrdD | Anaerobic ribonucleoside-triphosphate reductase; Identified by match to protein family HMM PF01228; match to protein family HMM PF03477; match to protein family HMM TIGR02487. (712 aa) |
| | ACD09017.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | holC | DNA polymerase III, chi subunit; Identified by match to protein family HMM PF04364. (147 aa) |
| | ACD10259.1 | Site-specific recombinase, phage integrase family protein; Identified by match to protein family HMM PF00589; Belongs to the 'phage' integrase family. (422 aa) |
| | ACD08147.1 | Putative type I restriction-modification system specificity subunit; Identified by match to protein family HMM PF01420. (360 aa) |
| | ACD08368.1 | N-6 DNA methylase; Identified by match to protein family HMM PF02384. (544 aa) |
| | ACD06704.1 | Type III restriction enzyme, res subunit; Identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851. (1137 aa) |
| | ACD07756.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD09306.1 | Transposase OrfA; Identified by match to protein family HMM PF01527. (102 aa) |
| | ACD06635.1 | Conserved domain protein; Identified by match to protein family HMM PF03400. (55 aa) |
| | priB | Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT; Belongs to the PriB family. (104 aa) |
| | ACD08099.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | mutL | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (615 aa) |
| | ACD10155.1 | Site-specific recombinase, phage integrase family protein; Belongs to the 'phage' integrase family. (334 aa) |
| | ACD09181.1 | Conserved hypothetical protein. (179 aa) |
| | ACD06687.1 | Transposase family; Identified by match to protein family HMM PF01527. (100 aa) |
| | ACD10062.1 | IS629 transposase orfB; Identified by match to protein family HMM PF00665. (296 aa) |
| | ACD08928.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ssb2 | Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (171 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (471 aa) |
| | ACD09466.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (125 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | ACD08943.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD07363.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD09149.1 | Insertion sequence 2 OrfB protein. (65 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa) |
| | tatD | Deoxyribonuclease TatD; 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily. (264 aa) |
| | recQ | ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF09382; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389. (609 aa) |
| | ACD09114.1 | IS1 transposase; Identified by match to protein family HMM PF03400. (131 aa) |
| | uvrD | DNA helicase II; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01075. (720 aa) |
| | xerC | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges t [...] (298 aa) |
| | ACD07140.1 | IS1294, transposase; Identified by match to protein family HMM PF04986. (399 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (804 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (357 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (467 aa) |
| | ACD10112.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD08156.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | rep | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (673 aa) |
| | ACD07099.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (460 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa) |
| | ssb | Single-strand binding protein; Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. (144 aa) |
| | ACD07733.1 | Site-specific recombinase, phage integrase family; Identified by match to protein family HMM PF00589; Belongs to the 'phage' integrase family. (439 aa) |
| | mutM | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | ACD06817.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (398 aa) |
| | ACD08298.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD06386.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | tag | DNA-3-methyladenine glycosylase I; Identified by match to protein family HMM PF03352; match to protein family HMM TIGR00624. (187 aa) |
| | ACD09376.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | dam | DNA adenine methylase; Identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571. (278 aa) |
| | ACD06560.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | ACD06583.1 | IS4 ORF; Identified by match to protein family HMM PF01609. (395 aa) |
| | ACD09050.1 | DNA methylase, N4/N6-methyltransferase family; Identified by match to protein family HMM PF01555; Belongs to the N(4)/N(6)-methyltransferase family. (294 aa) |
| | ACD07692.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | diaA | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. (196 aa) |
| | mug | G/U mismatch-specific DNA glycosylase; Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells; Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. (168 aa) |
| | ACD06990.1 | IS4 transposase; Identified by match to protein family HMM PF01609. (448 aa) |
| | nrdE | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa) |
| | ACD07654.1 | IS2 transposase orfB; Identified by match to protein family HMM PF00665. (301 aa) |
| | ACD07840.1 | IS1 transposase orfB; Identified by match to protein family HMM PF03400. (167 aa) |
| | ACD09879.1 | Putative integrase; Identified by match to protein family HMM PF00589; Belongs to the 'phage' integrase family. (535 aa) |
| | recJ | single-stranded-DNA-specific exonuclease RecJ; Identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644. (577 aa) |
| | xerD | Tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges t [...] (298 aa) |
| | endA | Identified by match to protein family HMM PF04231. (235 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (360 aa) |
| | ACD07076.1 | IS1 transposase OrfB; Identified by match to protein family HMM PF03400. (134 aa) |
| | ACD09804.1 | IS1 transposase orfA; Identified by match to protein family HMM PF03811. (91 aa) |
